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Avidity and variable domain spacing strongly influence the therapeutic potency of bispecific antibodies against Crimean-Congo hemorrhagic fever virus.

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Title: Avidity and variable domain spacing strongly influence the therapeutic potency of bispecific antibodies against Crimean-Congo hemorrhagic fever virus.
Authors: Wang A; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA., Monticelli SR; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.; Geneva Foundation, Tacoma, Washington, USA., Wirchnianski AS; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA., Abelson DM; Mapp Biopharmaceutical, Inc., San Diego, California, USA., Kuehne AI; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA., Bakken RR; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA., Middlecamp M; Mapp Biopharmaceutical, Inc., San Diego, California, USA., Weingart M; Mapp Biopharmaceutical, Inc., San Diego, California, USA., Vergnolle O; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA., Bornholdt ZA; Mapp Biopharmaceutical, Inc., San Diego, California, USA., Moyer CL; Mapp Biopharmaceutical, Inc., San Diego, California, USA., Berrigan JL; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA., West BR; Mapp Biopharmaceutical, Inc., San Diego, California, USA., Fels JM; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA., Zeitlin L; Mapp Biopharmaceutical, Inc., San Diego, California, USA., Herbert AS; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA., Chandran K; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA., Bikash CR; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA., Lai JR; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA.
Source: MBio [mBio] 2025 May 14; Vol. 16 (5), pp. e0320224. Date of Electronic Publication: 2025 Apr 16.
Publication Type: Journal Article
Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Avidity and variable domain spacing strongly influence the therapeutic potency of bispecific antibodies against Crimean-Congo hemorrhagic fever virus.
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  Data: <searchLink fieldCode="AU" term="%22Wang+A%22">Wang A</searchLink>; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.<br /><searchLink fieldCode="AU" term="%22Monticelli+SR%22">Monticelli SR</searchLink>; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.; Geneva Foundation, Tacoma, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Wirchnianski+AS%22">Wirchnianski AS</searchLink>; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.<br /><searchLink fieldCode="AU" term="%22Abelson+DM%22">Abelson DM</searchLink>; Mapp Biopharmaceutical, Inc., San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Kuehne+AI%22">Kuehne AI</searchLink>; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Bakken+RR%22">Bakken RR</searchLink>; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Middlecamp+M%22">Middlecamp M</searchLink>; Mapp Biopharmaceutical, Inc., San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Weingart+M%22">Weingart M</searchLink>; Mapp Biopharmaceutical, Inc., San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Vergnolle+O%22">Vergnolle O</searchLink>; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA.<br /><searchLink fieldCode="AU" term="%22Bornholdt+ZA%22">Bornholdt ZA</searchLink>; Mapp Biopharmaceutical, Inc., San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Moyer+CL%22">Moyer CL</searchLink>; Mapp Biopharmaceutical, Inc., San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Berrigan+JL%22">Berrigan JL</searchLink>; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.<br /><searchLink fieldCode="AU" term="%22West+BR%22">West BR</searchLink>; Mapp Biopharmaceutical, Inc., San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Fels+JM%22">Fels JM</searchLink>; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.<br /><searchLink fieldCode="AU" term="%22Zeitlin+L%22">Zeitlin L</searchLink>; Mapp Biopharmaceutical, Inc., San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Herbert+AS%22">Herbert AS</searchLink>; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Chandran+K%22">Chandran K</searchLink>; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.<br /><searchLink fieldCode="AU" term="%22Bikash+CR%22">Bikash CR</searchLink>; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA.<br /><searchLink fieldCode="AU" term="%22Lai+JR%22">Lai JR</searchLink>; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA.
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  Data: <searchLink fieldCode="JN" term="%22101519231%22">MBio</searchLink> [mBio] 2025 May 14; Vol. 16 (5), pp. e0320224. <i>Date of Electronic Publication: </i>2025 Apr 16.
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