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Multi-omic and spatial analysis of mouse kidneys highlights sex-specific differences in gene regulation across the lifespan.

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Title: Multi-omic and spatial analysis of mouse kidneys highlights sex-specific differences in gene regulation across the lifespan.
Authors: Chen S; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA., Liu R; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA., Mo CK; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA., Wendl MC; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA.; Department of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, MO, USA., Houston A; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA., Lal P; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA., Zhao Y; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA., Caravan W; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA., Shinkle AT; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA., Abedin-Do A; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA., Naser Al Deen N; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA., Sato K; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA., Li X; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA., Targino da Costa ALN; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA., Li Y; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA., Karpova A; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA., Herndon JM; Department of Surgery, Washington University in St. Louis, St. Louis, MO, USA., Artyomov MN; Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO, USA., Rubin JB; Department of Paediatrics, Washington University School of Medicine St Louis, St. Louis, MO, USA.; Department of Neuroscience, Washington University School of Medicine St Louis, St. Louis, MO, USA., Jain S; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO, USA.; Department of Paediatrics, Washington University School of Medicine St Louis, St. Louis, MO, USA., Li X; Samuel Oschin Comprehensive Cancer Institute, Department of Medicine, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Stewart SA; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO, USA.; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA., Ding L; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA. lding@wustl.edu.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA. lding@wustl.edu.; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA. lding@wustl.edu.; Department of Genetics, Washington University in St. Louis, St. Louis, MO, USA. lding@wustl.edu., Chen F; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA. fchen@wustl.edu.; Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO, USA. fchen@wustl.edu.; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA. fchen@wustl.edu.
Source: Nature genetics [Nat Genet] 2025 May; Vol. 57 (5), pp. 1213-1227. Date of Electronic Publication: 2025 Apr 21.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
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  Data: Multi-omic and spatial analysis of mouse kidneys highlights sex-specific differences in gene regulation across the lifespan.
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  Data: <searchLink fieldCode="AU" term="%22Chen+S%22">Chen S</searchLink>; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Liu+R%22">Liu R</searchLink>; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Mo+CK%22">Mo CK</searchLink>; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Wendl+MC%22">Wendl MC</searchLink>; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA.; Department of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Houston+A%22">Houston A</searchLink>; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Lal+P%22">Lal P</searchLink>; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+Y%22">Zhao Y</searchLink>; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Caravan+W%22">Caravan W</searchLink>; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Shinkle+AT%22">Shinkle AT</searchLink>; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Abedin-Do+A%22">Abedin-Do A</searchLink>; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Naser+Al+Deen+N%22">Naser Al Deen N</searchLink>; 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McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, USA. lding@wustl.edu.; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA. lding@wustl.edu.; Department of Genetics, Washington University in St. Louis, St. Louis, MO, USA. lding@wustl.edu.<br /><searchLink fieldCode="AU" term="%22Chen+F%22">Chen F</searchLink>; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA. fchen@wustl.edu.; Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO, USA. fchen@wustl.edu.; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA. fchen@wustl.edu.
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  Data: <searchLink fieldCode="JN" term="%229216904%22">Nature genetics</searchLink> [Nat Genet] 2025 May; Vol. 57 (5), pp. 1213-1227. <i>Date of Electronic Publication: </i>2025 Apr 21.
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