Novel humanized CD19-CAR-T (Now talicabtagene autoleucel, Tali-cel™) cells in relapsed/ refractory pediatric B-acute lymphoblastic leukemia- an open-label single-arm phase-I/Ib study.
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| Title: | Novel humanized CD19-CAR-T (Now talicabtagene autoleucel, Tali-cel™) cells in relapsed/ refractory pediatric B-acute lymphoblastic leukemia- an open-label single-arm phase-I/Ib study. |
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| Authors: | Narula G; Department of Pediatric Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India. drgauravnarula@gmail.com., Keerthivasagam S; Department of Pediatric Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.; Department of Medical Oncology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India., Jain H; Department of Medical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India., Punatar S; Bone marrow transplant unit, Department of Medical Oncology, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Homi Bhabha National Institute, Mumbai, India., Chichra A; Bone marrow transplant unit, Department of Medical Oncology, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Homi Bhabha National Institute, Mumbai, India., Dhamne C; Department of Pediatric Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India., Tembhare P; Department of Hematopathology, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Homi Bhabha National Institute, Navi Mumbai, India., Subramanian PG; Department of Hematopathology, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Homi Bhabha National Institute, Navi Mumbai, India., Patkar N; Department of Hematopathology, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Homi Bhabha National Institute, Navi Mumbai, India., Poojary M; Department of Transfusion Medicine, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Homi Bhabha National Institute, Navi Mumbai, India., Gokarn A; Bone marrow transplant unit, Department of Medical Oncology, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Homi Bhabha National Institute, Mumbai, India., Mirgh S; Bone marrow transplant unit, Department of Medical Oncology, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Homi Bhabha National Institute, Mumbai, India., Jindal N; Bone marrow transplant unit, Department of Medical Oncology, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Homi Bhabha National Institute, Mumbai, India., Nisar A; Scientific Officer (D), CAR-T and Cell Therapy Centre, ACTREC, Tata Memorial Centre, Mumbai, India., Pandit D; CAR-T and Cell Therapy Centre, ACTREC, Tata Memorial Centre, Kharghar, India., Pandit K; CAR-T and Cell Therapy Centre, ACTREC, Tata Memorial Centre, Kharghar, India., Dwivedi A; Department of Biosciences & Bioengineering, Indian Institute of Technology Bombay, Mumbai, India.; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Karulkar A; Department of Biosciences & Bioengineering, Indian Institute of Technology Bombay, Mumbai, India.; Immunoadoptive Cell Therapy Private Limited (ImmunoACT), Mumbai, India., Jaiswal AK; Department of Biosciences & Bioengineering, Indian Institute of Technology Bombay, Mumbai, India., Khan A; Department of Biosciences & Bioengineering, Indian Institute of Technology Bombay, Mumbai, India., Shah S; Immunoadoptive Cell Therapy Private Limited (ImmunoACT), Mumbai, India., Rafiq A; Department of Biosciences & Bioengineering, Indian Institute of Technology Bombay, Mumbai, India., Basu M; Immunoadoptive Cell Therapy Private Limited (ImmunoACT), Mumbai, India., Pendhari J; Department of Biosciences & Bioengineering, Indian Institute of Technology Bombay, Mumbai, India., Asija S; Department of Biosciences & Bioengineering, Indian Institute of Technology Bombay, Mumbai, India., Chowdury A; Department of Biosciences & Bioengineering, Indian Institute of Technology Bombay, Mumbai, India., Banik A; Department of Biosciences & Bioengineering, Indian Institute of Technology Bombay, Mumbai, India., Moulik NR; Department of Pediatric Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India., Srinivasan S; Department of Pediatric Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India., Bhosle S; Department of Critical Care and Anaesthesiology, Tata Memorial Center, Homi Bhabha National Institute, Mumbai, India., Hiregoudar S; Department of Transfusion Medicine, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Homi Bhabha National Institute, Navi Mumbai, India., Ojha S; Department of Transfusion Medicine, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Homi Bhabha National Institute, Navi Mumbai, India., Nayak L; Department of Medical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India., Thorat J; Department of Medical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India., Bagal B; Department of Medical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India., Sengar M; Department of Medical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India., Khattry N; Bone marrow transplant unit, Department of Medical Oncology, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Homi Bhabha National Institute, Mumbai, India., Banavali S; Director Academics and Professor Medical Oncology, Tata Memorial Center, Homi Bhabha National Institute, Mumbai, India., Highfill S; Center for Cellular Engineering, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Shah NN; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Purwar R; Department of Biosciences & Bioengineering, Indian Institute of Technology Bombay, Mumbai, India.; Immunoadoptive Cell Therapy Private Limited (ImmunoACT), Mumbai, India. |
| Source: | Blood cancer journal [Blood Cancer J] 2025 Apr 24; Vol. 15 (1), pp. 75. Date of Electronic Publication: 2025 Apr 24. |
| Publication Type: | Journal Article; Clinical Trial, Phase I |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101568469 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-5385 (Electronic) Linking ISSN: 20445385 NLM ISO Abbreviation: Blood Cancer J Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40274761 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Novel humanized CD19-CAR-T (Now talicabtagene autoleucel, Tali-cel™) cells in relapsed/ refractory pediatric B-acute lymphoblastic leukemia- an open-label single-arm phase-I/Ib study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Narula+G%22">Narula G</searchLink>; Department of Pediatric Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India. drgauravnarula@gmail.com.<br /><searchLink fieldCode="AU" term="%22Keerthivasagam+S%22">Keerthivasagam S</searchLink>; Department of Pediatric Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.; Department of Medical Oncology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.<br /><searchLink fieldCode="AU" term="%22Jain+H%22">Jain H</searchLink>; Department of Medical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Punatar+S%22">Punatar S</searchLink>; Bone marrow transplant unit, Department of Medical Oncology, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Homi Bhabha National Institute, Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Chichra+A%22">Chichra A</searchLink>; Bone marrow transplant unit, Department of Medical Oncology, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Homi Bhabha National Institute, Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Dhamne+C%22">Dhamne C</searchLink>; Department of Pediatric Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Tembhare+P%22">Tembhare P</searchLink>; Department of Hematopathology, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Homi Bhabha National Institute, Navi Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Subramanian+PG%22">Subramanian PG</searchLink>; Department of Hematopathology, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Homi Bhabha National Institute, Navi Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Patkar+N%22">Patkar N</searchLink>; Department of Hematopathology, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Homi Bhabha National Institute, Navi Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Poojary+M%22">Poojary M</searchLink>; Department of Transfusion Medicine, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Homi Bhabha National Institute, Navi Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Gokarn+A%22">Gokarn A</searchLink>; Bone marrow transplant unit, Department of Medical Oncology, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Homi Bhabha National Institute, Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Mirgh+S%22">Mirgh S</searchLink>; Bone marrow transplant unit, Department of Medical Oncology, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Homi Bhabha National Institute, Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Jindal+N%22">Jindal N</searchLink>; Bone marrow transplant unit, Department of Medical Oncology, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Homi Bhabha National Institute, Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Nisar+A%22">Nisar A</searchLink>; Scientific Officer (D), CAR-T and Cell Therapy Centre, ACTREC, Tata Memorial Centre, Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Pandit+D%22">Pandit D</searchLink>; CAR-T and Cell Therapy Centre, ACTREC, Tata Memorial Centre, Kharghar, India.<br /><searchLink fieldCode="AU" term="%22Pandit+K%22">Pandit K</searchLink>; CAR-T and Cell Therapy Centre, ACTREC, Tata Memorial Centre, Kharghar, India.<br /><searchLink fieldCode="AU" term="%22Dwivedi+A%22">Dwivedi A</searchLink>; Department of Biosciences & Bioengineering, Indian Institute of Technology Bombay, Mumbai, India.; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Karulkar+A%22">Karulkar A</searchLink>; Department of Biosciences & Bioengineering, Indian Institute of Technology Bombay, Mumbai, India.; Immunoadoptive Cell Therapy Private Limited (ImmunoACT), Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Jaiswal+AK%22">Jaiswal AK</searchLink>; Department of Biosciences & Bioengineering, Indian Institute of Technology Bombay, Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Khan+A%22">Khan A</searchLink>; Department of Biosciences & Bioengineering, Indian Institute of Technology Bombay, Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Shah+S%22">Shah S</searchLink>; Immunoadoptive Cell Therapy Private Limited (ImmunoACT), Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Rafiq+A%22">Rafiq A</searchLink>; Department of Biosciences & Bioengineering, Indian Institute of Technology Bombay, Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Basu+M%22">Basu M</searchLink>; Immunoadoptive Cell Therapy Private Limited (ImmunoACT), Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Pendhari+J%22">Pendhari J</searchLink>; Department of Biosciences & Bioengineering, Indian Institute of Technology Bombay, Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Asija+S%22">Asija S</searchLink>; Department of Biosciences & Bioengineering, Indian Institute of Technology Bombay, Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Chowdury+A%22">Chowdury A</searchLink>; Department of Biosciences & Bioengineering, Indian Institute of Technology Bombay, Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Banik+A%22">Banik A</searchLink>; Department of Biosciences & Bioengineering, Indian Institute of Technology Bombay, Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Moulik+NR%22">Moulik NR</searchLink>; Department of Pediatric Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Srinivasan+S%22">Srinivasan S</searchLink>; Department of Pediatric Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Bhosle+S%22">Bhosle S</searchLink>; Department of Critical Care and Anaesthesiology, Tata Memorial Center, Homi Bhabha National Institute, Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Hiregoudar+S%22">Hiregoudar S</searchLink>; Department of Transfusion Medicine, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Homi Bhabha National Institute, Navi Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Ojha+S%22">Ojha S</searchLink>; Department of Transfusion Medicine, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Homi Bhabha National Institute, Navi Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Nayak+L%22">Nayak L</searchLink>; Department of Medical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Thorat+J%22">Thorat J</searchLink>; Department of Medical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Bagal+B%22">Bagal B</searchLink>; Department of Medical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Sengar+M%22">Sengar M</searchLink>; Department of Medical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Khattry+N%22">Khattry N</searchLink>; Bone marrow transplant unit, Department of Medical Oncology, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Homi Bhabha National Institute, Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Banavali+S%22">Banavali S</searchLink>; Director Academics and Professor Medical Oncology, Tata Memorial Center, Homi Bhabha National Institute, Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Highfill+S%22">Highfill S</searchLink>; Center for Cellular Engineering, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Shah+NN%22">Shah NN</searchLink>; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Purwar+R%22">Purwar R</searchLink>; Department of Biosciences & Bioengineering, Indian Institute of Technology Bombay, Mumbai, India.; Immunoadoptive Cell Therapy Private Limited (ImmunoACT), Mumbai, India. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101568469%22">Blood cancer journal</searchLink> [Blood Cancer J] 2025 Apr 24; Vol. 15 (1), pp. 75. <i>Date of Electronic Publication: </i>2025 Apr 24. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Clinical Trial, Phase I – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101568469 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2044-5385 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220445385%22">20445385 </searchLink><i>NLM ISO Abbreviation: </i>Blood Cancer J <i>Subsets: </i>MEDLINE |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41408-025-01279-9 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 75 Titles: – TitleFull: Novel humanized CD19-CAR-T (Now talicabtagene autoleucel, Tali-cel™) cells in relapsed/ refractory pediatric B-acute lymphoblastic leukemia- an open-label single-arm phase-I/Ib study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Narula G – PersonEntity: Name: NameFull: Keerthivasagam S – PersonEntity: Name: NameFull: Jain H – PersonEntity: Name: NameFull: Punatar S – PersonEntity: Name: NameFull: Chichra A – PersonEntity: Name: NameFull: Dhamne C – PersonEntity: Name: NameFull: Tembhare P – PersonEntity: Name: NameFull: Subramanian PG – PersonEntity: Name: NameFull: Patkar N – PersonEntity: Name: NameFull: Poojary M – PersonEntity: Name: NameFull: Gokarn A – PersonEntity: Name: NameFull: Mirgh S – PersonEntity: Name: NameFull: Jindal N – PersonEntity: Name: NameFull: Nisar A – PersonEntity: Name: NameFull: Pandit D – PersonEntity: Name: NameFull: Pandit K – PersonEntity: Name: NameFull: Dwivedi A – PersonEntity: Name: NameFull: Karulkar A – PersonEntity: Name: NameFull: Jaiswal AK – PersonEntity: Name: NameFull: Khan A – PersonEntity: Name: NameFull: Shah S – PersonEntity: Name: NameFull: Rafiq A – PersonEntity: Name: NameFull: Basu M – PersonEntity: Name: NameFull: Pendhari J – PersonEntity: Name: NameFull: Asija S – PersonEntity: Name: NameFull: Chowdury A – PersonEntity: Name: NameFull: Banik A – PersonEntity: Name: NameFull: Moulik NR – PersonEntity: Name: NameFull: Srinivasan S – PersonEntity: Name: NameFull: Bhosle S – PersonEntity: Name: NameFull: Hiregoudar S – PersonEntity: Name: NameFull: Ojha S – PersonEntity: Name: NameFull: Nayak L – PersonEntity: Name: NameFull: Thorat J – PersonEntity: Name: NameFull: Bagal B – PersonEntity: Name: NameFull: Sengar M – PersonEntity: Name: NameFull: Khattry N – PersonEntity: Name: NameFull: Banavali S – PersonEntity: Name: NameFull: Highfill S – PersonEntity: Name: NameFull: Shah NN – PersonEntity: Name: NameFull: Purwar R IsPartOfRelationships: – BibEntity: Dates: – D: 24 M: 04 Text: 2025 Apr 24 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 2044-5385 Numbering: – Type: volume Value: 15 – Type: issue Value: 1 Titles: – TitleFull: Blood cancer journal Type: main |
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