Novel humanized CD19-CAR-T (Now talicabtagene autoleucel, Tali-cel™) cells in relapsed/ refractory pediatric B-acute lymphoblastic leukemia- an open-label single-arm phase-I/Ib study.
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| Title: | Novel humanized CD19-CAR-T (Now talicabtagene autoleucel, Tali-cel™) cells in relapsed/ refractory pediatric B-acute lymphoblastic leukemia- an open-label single-arm phase-I/Ib study. |
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| Authors: | Narula G; Department of Pediatric Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India. drgauravnarula@gmail.com., Keerthivasagam S; Department of Pediatric Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.; Department of Medical Oncology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India., Jain H; Department of Medical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India., Punatar S; Bone marrow transplant unit, Department of Medical Oncology, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Homi Bhabha National Institute, Mumbai, India., Chichra A; Bone marrow transplant unit, Department of Medical Oncology, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Homi Bhabha National Institute, Mumbai, India., Dhamne C; Department of Pediatric Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India., Tembhare P; Department of Hematopathology, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Homi Bhabha National Institute, Navi Mumbai, India., Subramanian PG; Department of Hematopathology, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Homi Bhabha National Institute, Navi Mumbai, India., Patkar N; Department of Hematopathology, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Homi Bhabha National Institute, Navi Mumbai, India., Poojary M; Department of Transfusion Medicine, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Homi Bhabha National Institute, Navi Mumbai, India., Gokarn A; Bone marrow transplant unit, Department of Medical Oncology, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Homi Bhabha National Institute, Mumbai, India., Mirgh S; Bone marrow transplant unit, Department of Medical Oncology, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Homi Bhabha National Institute, Mumbai, India., Jindal N; Bone marrow transplant unit, Department of Medical Oncology, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Homi Bhabha National Institute, Mumbai, India., Nisar A; Scientific Officer (D), CAR-T and Cell Therapy Centre, ACTREC, Tata Memorial Centre, Mumbai, India., Pandit D; CAR-T and Cell Therapy Centre, ACTREC, Tata Memorial Centre, Kharghar, India., Pandit K; CAR-T and Cell Therapy Centre, ACTREC, Tata Memorial Centre, Kharghar, India., Dwivedi A; Department of Biosciences & Bioengineering, Indian Institute of Technology Bombay, Mumbai, India.; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Karulkar A; Department of Biosciences & Bioengineering, Indian Institute of Technology Bombay, Mumbai, India.; Immunoadoptive Cell Therapy Private Limited (ImmunoACT), Mumbai, India., Jaiswal AK; Department of Biosciences & Bioengineering, Indian Institute of Technology Bombay, Mumbai, India., Khan A; Department of Biosciences & Bioengineering, Indian Institute of Technology Bombay, Mumbai, India., Shah S; Immunoadoptive Cell Therapy Private Limited (ImmunoACT), Mumbai, India., Rafiq A; Department of Biosciences & Bioengineering, Indian Institute of Technology Bombay, Mumbai, India., Basu M; Immunoadoptive Cell Therapy Private Limited (ImmunoACT), Mumbai, India., Pendhari J; Department of Biosciences & Bioengineering, Indian Institute of Technology Bombay, Mumbai, India., Asija S; Department of Biosciences & Bioengineering, Indian Institute of Technology Bombay, Mumbai, India., Chowdury A; Department of Biosciences & Bioengineering, Indian Institute of Technology Bombay, Mumbai, India., Banik A; Department of Biosciences & Bioengineering, Indian Institute of Technology Bombay, Mumbai, India., Moulik NR; Department of Pediatric Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India., Srinivasan S; Department of Pediatric Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India., Bhosle S; Department of Critical Care and Anaesthesiology, Tata Memorial Center, Homi Bhabha National Institute, Mumbai, India., Hiregoudar S; Department of Transfusion Medicine, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Homi Bhabha National Institute, Navi Mumbai, India., Ojha S; Department of Transfusion Medicine, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Homi Bhabha National Institute, Navi Mumbai, India., Nayak L; Department of Medical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India., Thorat J; Department of Medical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India., Bagal B; Department of Medical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India., Sengar M; Department of Medical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India., Khattry N; Bone marrow transplant unit, Department of Medical Oncology, Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Homi Bhabha National Institute, Mumbai, India., Banavali S; Director Academics and Professor Medical Oncology, Tata Memorial Center, Homi Bhabha National Institute, Mumbai, India., Highfill S; Center for Cellular Engineering, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Shah NN; Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Purwar R; Department of Biosciences & Bioengineering, Indian Institute of Technology Bombay, Mumbai, India.; Immunoadoptive Cell Therapy Private Limited (ImmunoACT), Mumbai, India. |
| Source: | Blood cancer journal [Blood Cancer J] 2025 Apr 24; Vol. 15 (1), pp. 75. Date of Electronic Publication: 2025 Apr 24. |
| Publication Type: | Journal Article; Clinical Trial, Phase I |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101568469 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-5385 (Electronic) Linking ISSN: 20445385 NLM ISO Abbreviation: Blood Cancer J Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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