Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing.
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| Title: | Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing. |
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| Authors: | Pottier C; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. cpottier@wustl.edu.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium. cpottier@wustl.edu.; VIB Center for Molecular Neurology, VIB, Antwerp, Belgium. cpottier@wustl.edu.; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA. cpottier@wustl.edu.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St Louis, MO, USA. cpottier@wustl.edu., Küçükali F; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.; VIB Center for Molecular Neurology, VIB, Antwerp, Belgium., Baker M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Batzler A; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA., Jenkins GD; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA., van Blitterswijk M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Vicente CT; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.; VIB Center for Molecular Neurology, VIB, Antwerp, Belgium., De Coster W; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.; VIB Center for Molecular Neurology, VIB, Antwerp, Belgium., Wynants S; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.; VIB Center for Molecular Neurology, VIB, Antwerp, Belgium., Van de Walle P; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.; VIB Center for Molecular Neurology, VIB, Antwerp, Belgium., Ross OA; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Murray ME; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Faura J; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.; VIB Center for Molecular Neurology, VIB, Antwerp, Belgium., Haggarty SJ; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., van Rooij JG; Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands., Mol MO; Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands., Hsiung GR; Department of Medicine, Division of Neurology, University of British Columbia, Vancouver, BC, Canada., Graff C; Division of Neurogeriatrics, Karolinska Institutet, Solna, Sweden.; Unit for Hereditary Dementias, Karolinska University Hospital, Solna, Sweden., Öijerstedt L; Division of Neurogeriatrics, Karolinska Institutet, Solna, Sweden.; Unit for Hereditary Dementias, Karolinska University Hospital, Solna, Sweden., Neumann M; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Neuropathology, University of Tübingen, Tübingen, Germany., Asmann Y; Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL, USA., McDonnell SK; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA., Baheti S; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA., Josephs KA; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Whitwell JL; Department of Radiology, Mayo Clinic, Rochester, MN, USA., Bieniek KF; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; University of Texas Health Science Center San Antonio, San Antonio, TX, USA., Forsberg L; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Heuer H; Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Lago AL; Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Geier EG; Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Yokoyama JS; Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Oddi AP; Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Flanagan M; University of Texas Health Science Center San Antonio, San Antonio, TX, USA., Mao Q; Department of Pathology, University of Utah, Salt Lake City, UT, USA., Hodges JR; Central Clinical School and Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia., Kwok JB; University of Sydney, Sydney, NSW, Australia.; NeuRA, University of New South Wales, Randwick, NSW, Australia., Domoto-Reilly K; Department of Neurology, University of Washington, Seattle, WA, USA., Synofzik M; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Division Translational Genomics of Neurodegenerative Diseases, Center for Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany., Wilke C; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Division Translational Genomics of Neurodegenerative Diseases, Center for Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany., Onyike C; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA., Dickerson BC; Department of Neurology, Case Western Reserve University, Cleveland, OH, USA., Evers BM; Division of Neuropathology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Dugger BN; Department of Pathology and Laboratory Medicine, University of California, Davis Medical Center, Sacramento, CA, USA., Munoz DG; St. Michael's Hospital, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Keith J; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Sunnybrook Health Sciences Centre, Toronto, ON, Canada., Zinman L; Sunnybrook Health Sciences Centre, Toronto, ON, Canada., Rogaeva E; Krembil Discovery Tower, Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, ON, Canada., Suh E; Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Gefen T; Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University, Chicago, IL, USA., Geula C; Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University, Chicago, IL, USA., Weintraub S; Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University, Chicago, IL, USA., Diehl-Schmid J; Department of Psychiatry and Psychotherapy, Technical University of Munich, Munich, Germany.; kbo-Inn-Salzach-Klinikum, Clinical Center for Psychiatry, Psychotherapy, Psychosomatic Medicine, Geriatrics and Neurology, Wasserburg/Inn, Germany., Farlow MR; Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA., Edbauer D; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany., Woodruff BK; Department of Neurology, Mayo Clinic, Scottsdale, AZ, USA., Caselli RJ; Department of Neurology, Mayo Clinic, Scottsdale, AZ, USA., Donker Kaat LL; Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands., Huey ED; Department of Psychiatry and Human Behavior, Brown Alpert Medical School, Brown University, Providence, RI, USA., Reiman EM; Banner Alzheimer's Institute, Phoenix, AZ, USA., Mead S; MRC Prion Unit at University College London, Institute of Prion Diseases, London, UK., King A; Department of Basic and Clinical Neuroscience, London Neurodegenerative Diseases Brain Bank, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; Department of Clinical Neuropathology, King's College Hospital NHS Foundation Trust, London, UK., Roeber S; Centre for Neuropathology and Prion Research, Ludwig-Maximilians-University of Munich, Munich, Germany., Nana AL; Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Ertekin-Taner N; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Knopman DS; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Petersen RC; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Petrucelli L; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Uitti RJ; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Wszolek ZK; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Ramos EM; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA., Grinberg LT; Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Tempini MLG; Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Rosen HJ; Department of Pathology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Spina S; Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Piguet O; School of Psychology and Brain and Mind Centre, University of Sydney, Sydney, SWA, Australia., Grossman M; Department of Neurology, Penn Frontotemporal Degeneration Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Trojanowski JQ; Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Keene CD; University of Washington BioRepository and Integrated Neuropathology (BRaIN) lab, Harborview Medical Center, Seattle, WA, USA., Jin LW; M.I.N.D. Institute Laboratory, University of California, Davis Medical Center, Sacramento, CA, USA., Prudlo J; German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany.; Department of Neurology, Rostock University Medical Center, Rostock, Germany., Geschwind DH; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA., Rissman RA; Alzheimer's Therapeutic Research Institute, Keck School of Medicine of the University of Southern California, San Diego, CA, USA., Cruchaga C; Department of Psychiatry, Knight Alzheimer Disease Research Center, Washington University School of Medicine, Saint Louis, MO, USA., Ghetti B; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA., Halliday GM; University of Sydney, Sydney, NSW, Australia., Beach TG; Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, AZ, USA., Serrano GE; Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, AZ, USA., Arzberger T; Centre for Neuropathology and Prion Research, Ludwig-Maximilians-University of Munich, Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilians-University of Munich, Munich, Germany., Herms J; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Centre for Neuropathology and Prion Research, Ludwig-Maximilians-University of Munich, Munich, Germany., Boxer AL; Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Honig LS; Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA., Vonsattel JP; Department of Pathology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA., Lopez OL; Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA., Kofler J; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA., White CL 3rd; Division of Neuropathology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Gearing M; Department of Pathology and Laboratory Medicine and Department of Neurology, Emory University, Atlanta, GA, USA., Glass J; Department of Pathology and Laboratory Medicine and Department of Neurology, Emory University, Atlanta, GA, USA., Rohrer JD; Department of Neurodegenerative Disease, Dementia Research Centre, University College London, Queen Square Institute of Neurology, London, UK., Irwin DJ; Department of Neurology, Penn Frontotemporal Degeneration Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Lee EB; Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Van Deerlin V; Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Castellani R; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Mesulam MM; Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University, Chicago, IL, USA., Tartaglia MC; Krembil Discovery Tower, Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, ON, Canada., Finger EC; Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada., Troakes C; Department of Basic and Clinical Neuroscience, London Neurodegenerative Diseases Brain Bank, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Al-Sarraj S; Department of Basic and Clinical Neuroscience, London Neurodegenerative Diseases Brain Bank, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; King's College Hospital NHS Foundation Trust, London, UK., Dalgard CL; Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., Miller BL; Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Seelaar H; Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands., Graff-Radford NR; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Boeve BF; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Mackenzie IR; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada., van Swieten JC; Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands., Seeley WW; Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Sleegers K; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.; VIB Center for Molecular Neurology, VIB, Antwerp, Belgium., Dickson DW; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA., Biernacka JM; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA., Rademakers R; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. rosa.rademakers@uantwerpen.vib.be.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium. rosa.rademakers@uantwerpen.vib.be.; VIB Center for Molecular Neurology, VIB, Antwerp, Belgium. rosa.rademakers@uantwerpen.vib.be. |
| Source: | Nature communications [Nat Commun] 2025 Apr 25; Vol. 16 (1), pp. 3914. Date of Electronic Publication: 2025 Apr 25. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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