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Parkinson's disease is characterized by vitamin B6-dependent inflammatory kynurenine pathway dysfunction.

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Title: Parkinson's disease is characterized by vitamin B6-dependent inflammatory kynurenine pathway dysfunction.
Authors: Wilson EN; Neurology & Neurological Sciences, Stanford University, Stanford, CA, USA. enwilson@stanford.edu.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA. enwilson@stanford.edu.; The Phil & Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA. enwilson@stanford.edu., Umans J; Neurology & Neurological Sciences, Stanford University, Stanford, CA, USA., Swarovski MS; Neurology & Neurological Sciences, Stanford University, Stanford, CA, USA., Minhas PS; Neurology & Neurological Sciences, Stanford University, Stanford, CA, USA., Mendiola JH; Neurology & Neurological Sciences, Stanford University, Stanford, CA, USA., Midttun Ø; Bevital, Bergen, Norway., Ulvik A; Bevital, Bergen, Norway., Shahid-Besanti M; Neurology & Neurological Sciences, Stanford University, Stanford, CA, USA., Linortner P; Neurology & Neurological Sciences, Stanford University, Stanford, CA, USA., Mhatre SD; Neurology & Neurological Sciences, Stanford University, Stanford, CA, USA., Wang Q; Neurology & Neurological Sciences, Stanford University, Stanford, CA, USA., Channappa D; Neurology & Neurological Sciences, Stanford University, Stanford, CA, USA.; Pathology, Stanford University, Stanford, CA, USA., Corso NK; Neurology & Neurological Sciences, Stanford University, Stanford, CA, USA., Tian L; Biomedical Data Science and Statistics, Stanford University, Stanford, CA, USA., Fredericks CA; Neurology, Yale University, New Haven, CT, USA., Kerchner GA; Pharma Research and Early Development, F. Hoffmann-La Roche, Ltd., Basel, Switzerland., Plowey ED; Pathology, Stanford University, Stanford, CA, USA., Cholerton B; Neurology & Neurological Sciences, Stanford University, Stanford, CA, USA., Ueland PM; Bevital, Bergen, Norway., Zabetian CP; VA Puget Sound Health Care System, Seattle, WA, USA.; Neurology, University of Washington, Seattle, WA, USA., Gray NE; Neurology, Oregon Health & Sciences University, Portland, OR, USA., Quinn JF; Neurology, Oregon Health & Sciences University, Portland, OR, USA.; Neurology, Portland VA Medical Center, Portland, OR, USA., Montine TJ; Pathology, Stanford University, Stanford, CA, USA., Sha SJ; Neurology & Neurological Sciences, Stanford University, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA., Longo FM; Neurology & Neurological Sciences, Stanford University, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA., Wolk DA; Neurology, University of Pennsylvania, Philadelphia, PA, USA., Chen-Plotkin A; Neurology, University of Pennsylvania, Philadelphia, PA, USA., Henderson VW; Neurology & Neurological Sciences, Stanford University, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA., Wyss-Coray T; Neurology & Neurological Sciences, Stanford University, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.; The Phil & Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA., Wagner AD; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.; Psychology, Stanford University, Stanford, CA, USA., Mormino EC; Neurology & Neurological Sciences, Stanford University, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA., Aghaeepour N; Biomedical Data Science and Statistics, Stanford University, Stanford, CA, USA.; Anesthesiology, Perioperative and Pain Medicine, Stanford University, Stanford, CA, USA.; Neonatal & Developmental Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.; Biomedical Informatics, Stanford University, Stanford, CA, USA., Poston KL; Neurology & Neurological Sciences, Stanford University, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.; The Phil & Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA.; Neurosurgery, Stanford University, Stanford, CA, USA., Andreasson KI; Neurology & Neurological Sciences, Stanford University, Stanford, CA, USA. kandreas@stanford.edu.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA. kandreas@stanford.edu.; The Phil & Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA. kandreas@stanford.edu.; Chan Zuckerberg Biohub, San Francisco, CA, USA. kandreas@stanford.edu.
Source: NPJ Parkinson's disease [NPJ Parkinsons Dis] 2025 Apr 26; Vol. 11 (1), pp. 96. Date of Electronic Publication: 2025 Apr 26.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101675390 Publication Model: Electronic Cited Medium: Print ISSN: 2373-8057 (Print) Linking ISSN: 23738057 NLM ISO Abbreviation: NPJ Parkinsons Dis Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Parkinson's disease is characterized by vitamin B6-dependent inflammatory kynurenine pathway dysfunction.
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