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Dissecting cross-population polygenic heterogeneity across respiratory and cardiometabolic diseases.

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Title: Dissecting cross-population polygenic heterogeneity across respiratory and cardiometabolic diseases.
Authors: Yamamoto Y; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan., Shirai Y; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan.; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Sonehara K; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Namba S; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Ojima T; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Graduate School of Medicine, Tohoku University, Sendai, Japan.; Center for Advanced Intelligence Project, RIKEN, Tokyo, Japan.; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Yamamoto K; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan.; Department of Pediatrics, Osaka University Graduate School of Medicine, Suita, Japan., Edahiro R; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Suzuki K; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Kanai A; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan., Oda Y; Department of Lipidomics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Suzuki Y; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan., Morisaki T; Division of Molecular Pathology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Laboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan., Narita A; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Takeda Y; Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan., Tamiya G; Graduate School of Medicine, Tohoku University, Sendai, Japan.; Center for Advanced Intelligence Project, RIKEN, Tokyo, Japan.; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Yamamoto M; Graduate School of Medicine, Tohoku University, Sendai, Japan.; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Matsuda K; Laboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan., Kumanogoh A; Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Immunopathology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan.; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka University, Suita, Japan.; Center for Infectious Diseases for Education and Research (CiDER), Osaka University, Suita, Japan.; Japan Agency for Medical Research and Development-Core Research for Evolutional Science and Technology (AMED-CREST), Tokyo, Japan.; Center for Advanced Modalities and DDS (CAMaD), Osaka University, Suita, Japan., Yamauchi T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. tyamau@m.u-tokyo.ac.jp.; Japan Agency for Medical Research and Development-Core Research for Evolutional Science and Technology (AMED-CREST), Tokyo, Japan. tyamau@m.u-tokyo.ac.jp., Kadowaki T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. t-kadowaki@toranomon.kkr.or.jp.; Toranomon Hospital, Tokyo, Japan. t-kadowaki@toranomon.kkr.or.jp., Okada Y; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan. yuki-okada@m.u-tokyo.ac.jp.; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan. yuki-okada@m.u-tokyo.ac.jp.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. yuki-okada@m.u-tokyo.ac.jp.; Department of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. yuki-okada@m.u-tokyo.ac.jp.; Center for Infectious Diseases for Education and Research (CiDER), Osaka University, Suita, Japan. yuki-okada@m.u-tokyo.ac.jp.; Center for Advanced Modalities and DDS (CAMaD), Osaka University, Suita, Japan. yuki-okada@m.u-tokyo.ac.jp.; Premium Research Institute for Human Metaverse Medicine (WPI-PRIMe), Osaka University, Suita, Japan. yuki-okada@m.u-tokyo.ac.jp.
Corporate Authors: BioBank Japan Project
Source: Nature communications [Nat Commun] 2025 Apr 28; Vol. 16 (1), pp. 3765. Date of Electronic Publication: 2025 Apr 28.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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