Replicative DNA polymerase epsilon and delta holoenzymes show wide-ranging inhibition at G-quadruplexes in the human genome. - Hile SE; Weissensteiner MH; Pytko KG; Dahl J; Kejnovsky E; Kejnovská I; Hedglin M; Georgakopoulos-Soares I; Makova KD; Eckert KA (Nucleic acids research, 2025)