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Cognitive improvement effects of PF-04957325, a phosphodiesterase-8 inhibitor, in mouse models of Alzheimer's disease via modulating neuroinflammation.

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Title: Cognitive improvement effects of PF-04957325, a phosphodiesterase-8 inhibitor, in mouse models of Alzheimer's disease via modulating neuroinflammation.
Authors: Guo TY; Institute of Pharmacology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, Shandong, China., Zhang M; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai, China.; State Key Laboratory of Advanced Drug Delivery and Release Systems, Shandong Luye Pharmaceutical Co., Ltd., Yantai, Shandong, China., Lv YL; Institute of Pharmacology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, Shandong, China., Qiu NZ; Institute of Pharmacology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, Shandong, China., Chen RM; Institute of Pharmacology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, Shandong, China., Zhang FF; Institute of Pharmacology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, Shandong, China., Chen W; Institute of Pharmacology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, Shandong, China., Zhang F; Institute of Pharmacology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, Shandong, China., Gao YF; Institute of Pharmacology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, Shandong, China., Wang XD; Institute of Pharmacology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, Shandong, China., Zhang XH; Institute of Pharmacology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, Shandong, China., Chen MH; Institute of Pharmacology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, Shandong, China., Zhang HT; Institute of Pharmacology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, Shandong, China.; Department of Pharmacology, Qingdao University School of Pharmacy, Qingdao, Shandong, China., Wang H; Institute of Pharmacology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, Shandong, China.
Source: The international journal of neuropsychopharmacology [Int J Neuropsychopharmacol] 2025 May 09; Vol. 28 (5).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 9815893 Publication Model: Print Cited Medium: Internet ISSN: 1469-5111 (Electronic) Linking ISSN: 14611457 NLM ISO Abbreviation: Int J Neuropsychopharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Cognitive improvement effects of PF-04957325, a phosphodiesterase-8 inhibitor, in mouse models of Alzheimer's disease via modulating neuroinflammation.
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  Data: <searchLink fieldCode="AU" term="%22Guo+TY%22">Guo TY</searchLink>; Institute of Pharmacology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Zhang+M%22">Zhang M</searchLink>; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai, China.; State Key Laboratory of Advanced Drug Delivery and Release Systems, Shandong Luye Pharmaceutical Co., Ltd., Yantai, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Lv+YL%22">Lv YL</searchLink>; Institute of Pharmacology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Qiu+NZ%22">Qiu NZ</searchLink>; Institute of Pharmacology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Chen+RM%22">Chen RM</searchLink>; Institute of Pharmacology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Zhang+FF%22">Zhang FF</searchLink>; Institute of Pharmacology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Chen+W%22">Chen W</searchLink>; Institute of Pharmacology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Zhang+F%22">Zhang F</searchLink>; Institute of Pharmacology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Gao+YF%22">Gao YF</searchLink>; Institute of Pharmacology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Wang+XD%22">Wang XD</searchLink>; Institute of Pharmacology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Zhang+XH%22">Zhang XH</searchLink>; Institute of Pharmacology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Chen+MH%22">Chen MH</searchLink>; Institute of Pharmacology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Zhang+HT%22">Zhang HT</searchLink>; Institute of Pharmacology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, Shandong, China.; Department of Pharmacology, Qingdao University School of Pharmacy, Qingdao, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Institute of Pharmacology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, Shandong, China.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9815893 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1469-5111 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214611457%22">14611457 </searchLink><i>NLM ISO Abbreviation: </i>Int J Neuropsychopharmacol <i>Subsets: </i>MEDLINE
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              Text: 2025 May 09
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