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Apigenin mitigates oxidative stress, neuroinflammation, and cognitive impairment but enhances learning and memory in aluminum chloride-induced neurotoxicity in rats.

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Title: Apigenin mitigates oxidative stress, neuroinflammation, and cognitive impairment but enhances learning and memory in aluminum chloride-induced neurotoxicity in rats.
Authors: Oyagbemi AA; Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria., Femi-Akinlosotu OM; Developmental Neurobiology and Forensic Anatomy Unit, Department of Anatomy, College of Medicine, University of Ibadan, Ibadan, Nigeria., Obasa AA; Neuroscience Unit, Department of Veterinary Anatomy, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria., Ojo MS; Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria., Salami AT; Development of Physiology, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria., Ajibade TO; Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria., Onukak CE; Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria., Igado OO; Neuroscience Unit, Department of Veterinary Anatomy, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria., Esan OO; Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria., Oyagbemi TO; Federal College of Animal Health and Production Technology, Ibadan, Nigeria., Adeogun AV; Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria., Awoyomi OV; Federal College of Animal Health and Production Technology, Ibadan, Nigeria., Ikokide JE; Department of Theriogenology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria., Jaja IF; Department of Livestock and Pasture Science, Faculty of Science and Agriculture, University of Fort Hare, Alice, South Africa.; Department of Agriculture and Animal Health, University of South Africa, Roodepoort, Johannesburg, South Africa., Ola-Davies OE; Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria., Omobowale TO; Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria., Saba AB; Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria., Oguntibeju OO; Phytomedicine and Phytochemistry Group, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Bellville, South Africa., Nwulia E; College of Medicine, Department of Psychiatry and Behavioral Sciences, Howard University Hospital, Howard University, Washington, District of Columbia, USA., Yakubu MA; Department of Environmental & Interdisciplinary Sciences, College of Science, Engineering & Technology, Vascular Biology Unit, Center for Cardiovascular Diseases, COPHS, Texas Southern University, Houston, Texas, USA.
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2025 May; Vol. 21 (5), pp. e70223.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Apigenin mitigates oxidative stress, neuroinflammation, and cognitive impairment but enhances learning and memory in aluminum chloride-induced neurotoxicity in rats.
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  Data: <searchLink fieldCode="AU" term="%22Oyagbemi+AA%22">Oyagbemi AA</searchLink>; Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria.<br /><searchLink fieldCode="AU" term="%22Femi-Akinlosotu+OM%22">Femi-Akinlosotu OM</searchLink>; Developmental Neurobiology and Forensic Anatomy Unit, Department of Anatomy, College of Medicine, University of Ibadan, Ibadan, Nigeria.<br /><searchLink fieldCode="AU" term="%22Obasa+AA%22">Obasa AA</searchLink>; Neuroscience Unit, Department of Veterinary Anatomy, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria.<br /><searchLink fieldCode="AU" term="%22Ojo+MS%22">Ojo MS</searchLink>; Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria.<br /><searchLink fieldCode="AU" term="%22Salami+AT%22">Salami AT</searchLink>; Development of Physiology, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria.<br /><searchLink fieldCode="AU" term="%22Ajibade+TO%22">Ajibade TO</searchLink>; Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria.<br /><searchLink fieldCode="AU" term="%22Onukak+CE%22">Onukak CE</searchLink>; Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria.<br /><searchLink fieldCode="AU" term="%22Igado+OO%22">Igado OO</searchLink>; Neuroscience Unit, Department of Veterinary Anatomy, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria.<br /><searchLink fieldCode="AU" term="%22Esan+OO%22">Esan OO</searchLink>; Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria.<br /><searchLink fieldCode="AU" term="%22Oyagbemi+TO%22">Oyagbemi TO</searchLink>; Federal College of Animal Health and Production Technology, Ibadan, Nigeria.<br /><searchLink fieldCode="AU" term="%22Adeogun+AV%22">Adeogun AV</searchLink>; Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria.<br /><searchLink fieldCode="AU" term="%22Awoyomi+OV%22">Awoyomi OV</searchLink>; Federal College of Animal Health and Production Technology, Ibadan, Nigeria.<br /><searchLink fieldCode="AU" term="%22Ikokide+JE%22">Ikokide JE</searchLink>; Department of Theriogenology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria.<br /><searchLink fieldCode="AU" term="%22Jaja+IF%22">Jaja IF</searchLink>; Department of Livestock and Pasture Science, Faculty of Science and Agriculture, University of Fort Hare, Alice, South Africa.; Department of Agriculture and Animal Health, University of South Africa, Roodepoort, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Ola-Davies+OE%22">Ola-Davies OE</searchLink>; Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria.<br /><searchLink fieldCode="AU" term="%22Omobowale+TO%22">Omobowale TO</searchLink>; Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria.<br /><searchLink fieldCode="AU" term="%22Saba+AB%22">Saba AB</searchLink>; Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria.<br /><searchLink fieldCode="AU" term="%22Oguntibeju+OO%22">Oguntibeju OO</searchLink>; Phytomedicine and Phytochemistry Group, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Bellville, South Africa.<br /><searchLink fieldCode="AU" term="%22Nwulia+E%22">Nwulia E</searchLink>; College of Medicine, Department of Psychiatry and Behavioral Sciences, Howard University Hospital, Howard University, Washington, District of Columbia, USA.<br /><searchLink fieldCode="AU" term="%22Yakubu+MA%22">Yakubu MA</searchLink>; Department of Environmental & Interdisciplinary Sciences, College of Science, Engineering & Technology, Vascular Biology Unit, Center for Cardiovascular Diseases, COPHS, Texas Southern University, Houston, Texas, USA.
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  Data: <searchLink fieldCode="JN" term="%22101231978%22">Alzheimer's & dementia : the journal of the Alzheimer's Association</searchLink> [Alzheimers Dement] 2025 May; Vol. 21 (5), pp. e70223.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22John+Wiley+%26+Sons%2C+Ltd%22">John Wiley & Sons, Ltd </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101231978 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1552-5279 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215525260%22">15525260 </searchLink><i>NLM ISO Abbreviation: </i>Alzheimers Dement <i>Subsets: </i>MEDLINE
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