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Marine-Inspired Spirooxindole PIM-1 Kinase Inhibitors Endowed with Concomitant TRKA/CDK2 Inhibition for Multifaceted Non-Small Cell Lung Cancer Apoptotic Induction.

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Title: Marine-Inspired Spirooxindole PIM-1 Kinase Inhibitors Endowed with Concomitant TRKA/CDK2 Inhibition for Multifaceted Non-Small Cell Lung Cancer Apoptotic Induction.
Authors: Al-Jassas RM; Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh, 11451, Saudi Arabia., Islam MS; Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh, 11451, Saudi Arabia., Al-Majid AM; Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh, 11451, Saudi Arabia., Haukka M; Department of Chemistry, University of Jyväskylä, P.O. Box 35, FI-40014, Jyväskylä, Finland., Nafie MS; Department of Chemistry, College of Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates.; Chemistry Department, Faculty of Science, Suez Canal University, Ismailia, 41522, Egypt., Abu-Serie MM; Medical Biotechnology Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City), Alexandria, 21934, Egypt., Teleb M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, 21521, Egypt.; Department of Medicinal Chemistry, Faculty of Pharmacy, Alamein International University (AIU), Alamein City, 5060310, Egypt., Shaaban MM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, 21521, Egypt., Alayyaf AMA; Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh, 11451, Saudi Arabia., Domingo LR; Avd. Tirso de Molina 20, 46015, Valencia, Spain., Ashraf S; Dr. Panjwani Center for Molecular medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan., Ul-Haq Z; Dr. Panjwani Center for Molecular medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan., Abdel Aziz YM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt., Barakat A; Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh, 11451, Saudi Arabia.
Source: ChemMedChem [ChemMedChem] 2025 Jul 18; Vol. 20 (14), pp. e202500028. Date of Electronic Publication: 2025 Jun 01.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE
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  Data: Marine-Inspired Spirooxindole PIM-1 Kinase Inhibitors Endowed with Concomitant TRKA/CDK2 Inhibition for Multifaceted Non-Small Cell Lung Cancer Apoptotic Induction.
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  Data: <searchLink fieldCode="AU" term="%22Al-Jassas+RM%22">Al-Jassas RM</searchLink>; Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh, 11451, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Islam+MS%22">Islam MS</searchLink>; Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh, 11451, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Al-Majid+AM%22">Al-Majid AM</searchLink>; Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh, 11451, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Haukka+M%22">Haukka M</searchLink>; Department of Chemistry, University of Jyväskylä, P.O. Box 35, FI-40014, Jyväskylä, Finland.<br /><searchLink fieldCode="AU" term="%22Nafie+MS%22">Nafie MS</searchLink>; Department of Chemistry, College of Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates.; Chemistry Department, Faculty of Science, Suez Canal University, Ismailia, 41522, Egypt.<br /><searchLink fieldCode="AU" term="%22Abu-Serie+MM%22">Abu-Serie MM</searchLink>; Medical Biotechnology Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City), Alexandria, 21934, Egypt.<br /><searchLink fieldCode="AU" term="%22Teleb+M%22">Teleb M</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, 21521, Egypt.; Department of Medicinal Chemistry, Faculty of Pharmacy, Alamein International University (AIU), Alamein City, 5060310, Egypt.<br /><searchLink fieldCode="AU" term="%22Shaaban+MM%22">Shaaban MM</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, 21521, Egypt.<br /><searchLink fieldCode="AU" term="%22Alayyaf+AMA%22">Alayyaf AMA</searchLink>; Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh, 11451, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Domingo+LR%22">Domingo LR</searchLink>; Avd. Tirso de Molina 20, 46015, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Ashraf+S%22">Ashraf S</searchLink>; Dr. Panjwani Center for Molecular medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.<br /><searchLink fieldCode="AU" term="%22Ul-Haq+Z%22">Ul-Haq Z</searchLink>; Dr. Panjwani Center for Molecular medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.<br /><searchLink fieldCode="AU" term="%22Abdel+Aziz+YM%22">Abdel Aziz YM</searchLink>; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt.<br /><searchLink fieldCode="AU" term="%22Barakat+A%22">Barakat A</searchLink>; Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh, 11451, Saudi Arabia.
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  Data: <searchLink fieldCode="JN" term="%22101259013%22">ChemMedChem</searchLink> [ChemMedChem] 2025 Jul 18; Vol. 20 (14), pp. e202500028. <i>Date of Electronic Publication: </i>2025 Jun 01.
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