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The inhibitory receptor Siglec-E controls antigen-presenting cell activation and T cell-mediated transplant rejection.

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Title: The inhibitory receptor Siglec-E controls antigen-presenting cell activation and T cell-mediated transplant rejection.
Authors: Borges TJ; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA., Lima K; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA., Gassen RB; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA., Liu K; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA., Ganchiku Y; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA., Ribas GT; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA., Liao M; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA., Goncalves JIB; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA., Lape IT; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA., Rosales IA; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA., Zhao Y; Department of Cell and Developmental Biology, School of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA., Hui E; Department of Cell and Developmental Biology, School of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA., Fairchild RL; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland, OH 44196, USA.; Transplant Center, Cleveland Clinic, Cleveland, OH 44196, USA., LeGuern C; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA., Bonorino C; Immunotherapy Laboratory - (LAIT) - Department of Basic Health Sciences of Federal University of Health Sciences of Porto Alegre, UFCSPA, Porto Alegre 90050-170, Brazil., Calderwood SK; Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Madsen JC; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.; Division of Cardiac Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Riella LV; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.; Nephrology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Source: Science translational medicine [Sci Transl Med] 2025 May 07; Vol. 17 (797), pp. eads2694. Date of Electronic Publication: 2025 May 07.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The inhibitory receptor Siglec-E controls antigen-presenting cell activation and T cell-mediated transplant rejection.
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  Data: <searchLink fieldCode="AU" term="%22Borges+TJ%22">Borges TJ</searchLink>; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.<br /><searchLink fieldCode="AU" term="%22Lima+K%22">Lima K</searchLink>; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.<br /><searchLink fieldCode="AU" term="%22Gassen+RB%22">Gassen RB</searchLink>; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.<br /><searchLink fieldCode="AU" term="%22Liu+K%22">Liu K</searchLink>; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.<br /><searchLink fieldCode="AU" term="%22Ganchiku+Y%22">Ganchiku Y</searchLink>; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.<br /><searchLink fieldCode="AU" term="%22Ribas+GT%22">Ribas GT</searchLink>; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.<br /><searchLink fieldCode="AU" term="%22Liao+M%22">Liao M</searchLink>; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.<br /><searchLink fieldCode="AU" term="%22Goncalves+JIB%22">Goncalves JIB</searchLink>; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.<br /><searchLink fieldCode="AU" term="%22Lape+IT%22">Lape IT</searchLink>; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.<br /><searchLink fieldCode="AU" term="%22Rosales+IA%22">Rosales IA</searchLink>; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+Y%22">Zhao Y</searchLink>; Department of Cell and Developmental Biology, School of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.<br /><searchLink fieldCode="AU" term="%22Hui+E%22">Hui E</searchLink>; Department of Cell and Developmental Biology, School of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.<br /><searchLink fieldCode="AU" term="%22Fairchild+RL%22">Fairchild RL</searchLink>; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland, OH 44196, USA.; Transplant Center, Cleveland Clinic, Cleveland, OH 44196, USA.<br /><searchLink fieldCode="AU" term="%22LeGuern+C%22">LeGuern C</searchLink>; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.<br /><searchLink fieldCode="AU" term="%22Bonorino+C%22">Bonorino C</searchLink>; Immunotherapy Laboratory - (LAIT) - Department of Basic Health Sciences of Federal University of Health Sciences of Porto Alegre, UFCSPA, Porto Alegre 90050-170, Brazil.<br /><searchLink fieldCode="AU" term="%22Calderwood+SK%22">Calderwood SK</searchLink>; Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Madsen+JC%22">Madsen JC</searchLink>; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.; Division of Cardiac Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Riella+LV%22">Riella LV</searchLink>; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.; Nephrology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
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