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Activation of lysosomal iron triggers ferroptosis in cancer.

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Title: Activation of lysosomal iron triggers ferroptosis in cancer.
Authors: Cañeque T; Institut Curie, CNRS, INSERM, PSL Research University, Paris, France., Baron L; Institut Curie, CNRS, INSERM, PSL Research University, Paris, France., Müller S; Institut Curie, CNRS, INSERM, PSL Research University, Paris, France., Carmona A; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Colombeau L; Institut Curie, CNRS, INSERM, PSL Research University, Paris, France., Versini A; Institut Curie, CNRS, INSERM, PSL Research University, Paris, France., Solier S; Institut Curie, CNRS, INSERM, PSL Research University, Paris, France.; Department of Genetics, Institut Curie, Paris, France.; Paris Saclay University, UVSQ, Montigny-le-Bretonneux, France., Gaillet C; Institut Curie, CNRS, INSERM, PSL Research University, Paris, France., Sindikubwabo F; Institut Curie, CNRS, INSERM, PSL Research University, Paris, France., Sampaio JL; Institut Curie, CNRS, INSERM, PSL Research University, Paris, France., Sabatier M; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Mishima E; Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany., Picard-Bernes A; Institut Curie, CNRS, INSERM, PSL Research University, Paris, France., Syx L; Institut Curie, INSERM, Mines Paris Tech, PSL Research University, Paris, France., Servant N; Institut Curie, INSERM, Mines Paris Tech, PSL Research University, Paris, France., Lombard B; Institut Curie, PSL Research University, Paris, France., Loew D; Institut Curie, PSL Research University, Paris, France., Zheng J; Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany., Proneth B; Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany., Thoidingjam LK; Institut Curie, CNRS, INSERM, PSL Research University, Paris, France., Grimaud L; Ecole Normale Supérieure, CNRS, PSL Research University, Paris, France., Fraser CS; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Szylo KJ; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Der Kazarian E; CRCM, CNRS, INSERM, Institut Paoli-Calmettes, Aix-Marseille University, Marseille, France., Bonnet C; CRCM, CNRS, INSERM, Institut Paoli-Calmettes, Aix-Marseille University, Marseille, France., Charafe-Jauffret E; CRCM, CNRS, INSERM, Institut Paoli-Calmettes, Aix-Marseille University, Marseille, France., Ginestier C; CRCM, CNRS, INSERM, Institut Paoli-Calmettes, Aix-Marseille University, Marseille, France., Santofimia-Castaño P; CRCM, CNRS, INSERM, Institut Paoli-Calmettes, Aix-Marseille University, Parc Scientifique et Technologique de Luminy, Marseille, France., Estaras M; CRCM, CNRS, INSERM, Institut Paoli-Calmettes, Aix-Marseille University, Parc Scientifique et Technologique de Luminy, Marseille, France., Dusetti N; CRCM, CNRS, INSERM, Institut Paoli-Calmettes, Aix-Marseille University, Parc Scientifique et Technologique de Luminy, Marseille, France., Iovanna JL; CRCM, CNRS, INSERM, Institut Paoli-Calmettes, Aix-Marseille University, Parc Scientifique et Technologique de Luminy, Marseille, France., Cunha AS; Department of Digestive and Medical Oncology, Paris Saclay University and Paul-Brousse Hospital (APHP Sud), Villejuif, France., Pittau G; Department of Digestive and Medical Oncology, Paris Saclay University and Paul-Brousse Hospital (APHP Sud), Villejuif, France., Hammel P; Department of Digestive and Medical Oncology, Paris Saclay University and Paul-Brousse Hospital (APHP Sud), Villejuif, France., Tzanis D; Department of Surgical Oncology, Institut Curie, Paris, France., Bonvalot S; Department of Surgical Oncology, Institut Curie, Paris, France., Watson S; Department of Medical Oncology, Institut Curie, INSERM, PSL Research University, Paris, France., Gandon V; Institut de Chimie Moléculaire et des Matériaux d'Orsay, CNRS, Paris Saclay University, Orsay, France., Upadhyay A; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada., Pratt DA; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada., Freitas FP; Rudolf-Virchow-Zentrum, Center for Integrative and Translational Bioimaging, Julius-Maximilians-Universität Würzburg, Würzburg, Germany., Friedmann Angeli JP; Rudolf-Virchow-Zentrum, Center for Integrative and Translational Bioimaging, Julius-Maximilians-Universität Würzburg, Würzburg, Germany., Stockwell BR; Department of Chemistry, Columbia University, New York, NY, USA.; Department of Biological Sciences, Columbia University, New York, NY, USA.; Department of Pathology and Cell Biology, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA., Conrad M; Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany.; Translational Redox Biology, TUM Natural School of Sciences, Technical University of Munich, Garching, Germany., Ubellacker JM; Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Rodriguez R; Institut Curie, CNRS, INSERM, PSL Research University, Paris, France. raphael.rodriguez@curie.fr.
Source: Nature [Nature] 2025 Jun; Vol. 642 (8067), pp. 492-500. Date of Electronic Publication: 2025 May 07.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
PubTypeId: academicJournal
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