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Quercetin Induces Apoptosis Through Downregulating P4HA2 and Inhibiting the PI3K/Akt/mTOR Axis in Hepatocellular Carcinoma Cells: An In Vitro Study.

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Title: Quercetin Induces Apoptosis Through Downregulating P4HA2 and Inhibiting the PI3K/Akt/mTOR Axis in Hepatocellular Carcinoma Cells: An In Vitro Study.
Authors: Zhang J; The Third People's Hospital of Bengbu Affiliated to Bengbu Medical University, Bengbu, China.; Anhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Bengbu, China.; Bengbu Medical University Key Laboratory of Cancer Research and Clinical Laboratory Diagnosis, Bengbu Medical University, Bengbu, China., Guo J; Bengbu Medical University Key Laboratory of Cancer Research and Clinical Laboratory Diagnosis, Bengbu Medical University, Bengbu, China., Qian Y; Bengbu Medical University Key Laboratory of Cancer Research and Clinical Laboratory Diagnosis, Bengbu Medical University, Bengbu, China., Yu L; Bengbu Medical University Key Laboratory of Cancer Research and Clinical Laboratory Diagnosis, Bengbu Medical University, Bengbu, China., Ma J; Bengbu Medical University Key Laboratory of Cancer Research and Clinical Laboratory Diagnosis, Bengbu Medical University, Bengbu, China., Gu B; The Third People's Hospital of Bengbu Affiliated to Bengbu Medical University, Bengbu, China., Tang W; The Third People's Hospital of Bengbu Affiliated to Bengbu Medical University, Bengbu, China.; Anhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Bengbu, China., Li Y; The Third People's Hospital of Bengbu Affiliated to Bengbu Medical University, Bengbu, China., Li H; The Third People's Hospital of Bengbu Affiliated to Bengbu Medical University, Bengbu, China., Wu W; Bengbu Medical University Key Laboratory of Cancer Research and Clinical Laboratory Diagnosis, Bengbu Medical University, Bengbu, China.; Department of Biochemistry and Molecular Biology, School of Laboratory Medicine, Bengbu Medical University, Bengbu, China.
Source: Cancer reports (Hoboken, N.J.) [Cancer Rep (Hoboken)] 2025 May; Vol. 8 (5), pp. e70220.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Inc Country of Publication: United States NLM ID: 101747728 Publication Model: Print Cited Medium: Internet ISSN: 2573-8348 (Electronic) Linking ISSN: 25738348 NLM ISO Abbreviation: Cancer Rep (Hoboken) Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Quercetin Induces Apoptosis Through Downregulating P4HA2 and Inhibiting the PI3K/Akt/mTOR Axis in Hepatocellular Carcinoma Cells: An In Vitro Study.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; The Third People's Hospital of Bengbu Affiliated to Bengbu Medical University, Bengbu, China.; Anhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Bengbu, China.; Bengbu Medical University Key Laboratory of Cancer Research and Clinical Laboratory Diagnosis, Bengbu Medical University, Bengbu, China.<br /><searchLink fieldCode="AU" term="%22Guo+J%22">Guo J</searchLink>; Bengbu Medical University Key Laboratory of Cancer Research and Clinical Laboratory Diagnosis, Bengbu Medical University, Bengbu, China.<br /><searchLink fieldCode="AU" term="%22Qian+Y%22">Qian Y</searchLink>; Bengbu Medical University Key Laboratory of Cancer Research and Clinical Laboratory Diagnosis, Bengbu Medical University, Bengbu, China.<br /><searchLink fieldCode="AU" term="%22Yu+L%22">Yu L</searchLink>; Bengbu Medical University Key Laboratory of Cancer Research and Clinical Laboratory Diagnosis, Bengbu Medical University, Bengbu, China.<br /><searchLink fieldCode="AU" term="%22Ma+J%22">Ma J</searchLink>; Bengbu Medical University Key Laboratory of Cancer Research and Clinical Laboratory Diagnosis, Bengbu Medical University, Bengbu, China.<br /><searchLink fieldCode="AU" term="%22Gu+B%22">Gu B</searchLink>; The Third People's Hospital of Bengbu Affiliated to Bengbu Medical University, Bengbu, China.<br /><searchLink fieldCode="AU" term="%22Tang+W%22">Tang W</searchLink>; The Third People's Hospital of Bengbu Affiliated to Bengbu Medical University, Bengbu, China.; Anhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Bengbu, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; The Third People's Hospital of Bengbu Affiliated to Bengbu Medical University, Bengbu, China.<br /><searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; The Third People's Hospital of Bengbu Affiliated to Bengbu Medical University, Bengbu, China.<br /><searchLink fieldCode="AU" term="%22Wu+W%22">Wu W</searchLink>; Bengbu Medical University Key Laboratory of Cancer Research and Clinical Laboratory Diagnosis, Bengbu Medical University, Bengbu, China.; Department of Biochemistry and Molecular Biology, School of Laboratory Medicine, Bengbu Medical University, Bengbu, China.
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  Data: <searchLink fieldCode="JN" term="%22101747728%22">Cancer reports (Hoboken, N.J.)</searchLink> [Cancer Rep (Hoboken)] 2025 May; Vol. 8 (5), pp. e70220.
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        Value: 10.1002/cnr2.70220
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      – TitleFull: Quercetin Induces Apoptosis Through Downregulating P4HA2 and Inhibiting the PI3K/Akt/mTOR Axis in Hepatocellular Carcinoma Cells: An In Vitro Study.
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            – D: 01
              M: 05
              Text: 2025 May
              Type: published
              Y: 2025
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