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Treatment options to support the elimination of hepatitis C: an open-label, factorial, randomised controlled non-inferiority trial.

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Title: Treatment options to support the elimination of hepatitis C: an open-label, factorial, randomised controlled non-inferiority trial.
Authors: Cooke GS; Department of Infectious Disease, Imperial College London, London, UK; NIHR BRC Imperial College NHS Trust, London, UK. Electronic address: g.cooke@imperial.ac.uk., Hung LM; Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam., Flower B; Department of Infectious Disease, Imperial College London, London, UK; NIHR BRC Imperial College NHS Trust, London, UK; Oxford University Clinical Research Unit (OUCRU), Ho Chi Minh City, Viet Nam., McCabe L; MRC Clinical Trial Unit at UCL, University College London, London, UK., Hang VTK; Oxford University Clinical Research Unit (OUCRU), Ho Chi Minh City, Viet Nam., Thu VT; Oxford University Clinical Research Unit (OUCRU), Ho Chi Minh City, Viet Nam., Thuan DT; Oxford University Clinical Research Unit (OUCRU), Ho Chi Minh City, Viet Nam., Dung NT; Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam., Phuong LT; Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam., Khoa DB; Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam., An NTC; Oxford University Clinical Research Unit (OUCRU), Ho Chi Minh City, Viet Nam., Thach PN; National Hospital of Tropical Diseases, Hanoi, Viet Nam., Huong VTT; National Hospital of Tropical Diseases, Hanoi, Viet Nam., Bich DT; National Hospital of Tropical Diseases, Hanoi, Viet Nam., Tuyen NK; Oxford University Clinical Research Unit (OUCRU), Hanoi, Viet Nam., Ansari MA; Oxford University Clinical Research Unit (OUCRU), Ho Chi Minh City, Viet Nam; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Le Ngoc C; Oxford University Clinical Research Unit (OUCRU), Ho Chi Minh City, Viet Nam., Quang VM; Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam., Phuong NTN; Oxford University Clinical Research Unit (OUCRU), Ho Chi Minh City, Viet Nam., Thao LT; Oxford University Clinical Research Unit (OUCRU), Ho Chi Minh City, Viet Nam., Tran NB; Oxford University Clinical Research Unit (OUCRU), Ho Chi Minh City, Viet Nam., Kestelyn E; Oxford University Clinical Research Unit (OUCRU), Ho Chi Minh City, Viet Nam; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Kingsley C; Department of Infectious Disease, Imperial College London, London, UK; NIHR BRC Imperial College NHS Trust, London, UK., Van Doorn R; Oxford University Clinical Research Unit (OUCRU), Hanoi, Viet Nam; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Rahman M; Oxford University Clinical Research Unit (OUCRU), Ho Chi Minh City, Viet Nam., Pett SL; MRC Clinical Trial Unit at UCL, University College London, London, UK., Thwaites GE; Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam; Oxford University Clinical Research Unit (OUCRU), Ho Chi Minh City, Viet Nam; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Barnes E; Nuffield Department of Medicine, University of Oxford, Oxford, UK; NIHR BRC Oxford University NHS Trust, Oxford, UK., Day JN; Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam; Oxford University Clinical Research Unit (OUCRU), Ho Chi Minh City, Viet Nam; Department of Clinical Microbiology and Infection, Royal Devon University Healthcare, Exeter, UK., Chau NVV; Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam., Walker AS; MRC Clinical Trial Unit at UCL, University College London, London, UK.
Source: Lancet (London, England) [Lancet] 2025 May 17; Vol. 405 (10491), pp. 1769-1780. Date of Electronic Publication: 2025 May 08.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study; Equivalence Trial; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 2985213R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-547X (Electronic) Linking ISSN: 01406736 NLM ISO Abbreviation: Lancet Subsets: MEDLINE
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  Data: Treatment options to support the elimination of hepatitis C: an open-label, factorial, randomised controlled non-inferiority trial.
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  Data: <searchLink fieldCode="AU" term="%22Cooke+GS%22">Cooke GS</searchLink>; Department of Infectious Disease, Imperial College London, London, UK; NIHR BRC Imperial College NHS Trust, London, UK. Electronic address: g.cooke@imperial.ac.uk.<br /><searchLink fieldCode="AU" term="%22Hung+LM%22">Hung LM</searchLink>; Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam.<br /><searchLink fieldCode="AU" term="%22Flower+B%22">Flower B</searchLink>; Department of Infectious Disease, Imperial College London, London, UK; NIHR BRC Imperial College NHS Trust, London, UK; Oxford University Clinical Research Unit (OUCRU), Ho Chi Minh City, Viet Nam.<br /><searchLink fieldCode="AU" term="%22McCabe+L%22">McCabe L</searchLink>; MRC Clinical Trial Unit at UCL, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Hang+VTK%22">Hang VTK</searchLink>; Oxford University Clinical Research Unit (OUCRU), Ho Chi Minh City, Viet Nam.<br /><searchLink fieldCode="AU" term="%22Thu+VT%22">Thu VT</searchLink>; Oxford University Clinical Research Unit (OUCRU), Ho Chi Minh City, Viet Nam.<br /><searchLink fieldCode="AU" term="%22Thuan+DT%22">Thuan DT</searchLink>; Oxford University Clinical Research Unit (OUCRU), Ho Chi Minh City, Viet Nam.<br /><searchLink fieldCode="AU" term="%22Dung+NT%22">Dung NT</searchLink>; Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam.<br /><searchLink fieldCode="AU" term="%22Phuong+LT%22">Phuong LT</searchLink>; Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam.<br /><searchLink fieldCode="AU" term="%22Khoa+DB%22">Khoa DB</searchLink>; Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam.<br /><searchLink fieldCode="AU" term="%22An+NTC%22">An NTC</searchLink>; Oxford University Clinical Research Unit (OUCRU), Ho Chi Minh City, Viet Nam.<br /><searchLink fieldCode="AU" term="%22Thach+PN%22">Thach PN</searchLink>; National Hospital of Tropical Diseases, Hanoi, Viet Nam.<br /><searchLink fieldCode="AU" term="%22Huong+VTT%22">Huong VTT</searchLink>; National Hospital of Tropical Diseases, Hanoi, Viet Nam.<br /><searchLink fieldCode="AU" term="%22Bich+DT%22">Bich DT</searchLink>; National Hospital of Tropical Diseases, Hanoi, Viet Nam.<br /><searchLink fieldCode="AU" term="%22Tuyen+NK%22">Tuyen NK</searchLink>; Oxford University Clinical Research Unit (OUCRU), Hanoi, Viet Nam.<br /><searchLink fieldCode="AU" term="%22Ansari+MA%22">Ansari MA</searchLink>; Oxford University Clinical Research Unit (OUCRU), Ho Chi Minh City, Viet Nam; Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Le+Ngoc+C%22">Le Ngoc C</searchLink>; Oxford University Clinical Research Unit (OUCRU), Ho Chi Minh City, Viet Nam.<br /><searchLink fieldCode="AU" term="%22Quang+VM%22">Quang VM</searchLink>; Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam.<br /><searchLink fieldCode="AU" term="%22Phuong+NTN%22">Phuong NTN</searchLink>; Oxford University Clinical Research Unit (OUCRU), Ho Chi Minh City, Viet Nam.<br /><searchLink fieldCode="AU" term="%22Thao+LT%22">Thao LT</searchLink>; Oxford University Clinical Research Unit (OUCRU), Ho Chi Minh City, Viet Nam.<br /><searchLink fieldCode="AU" term="%22Tran+NB%22">Tran NB</searchLink>; Oxford University Clinical Research Unit (OUCRU), Ho Chi Minh City, Viet Nam.<br /><searchLink fieldCode="AU" term="%22Kestelyn+E%22">Kestelyn E</searchLink>; Oxford University Clinical Research Unit (OUCRU), Ho Chi Minh City, Viet Nam; Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Kingsley+C%22">Kingsley C</searchLink>; Department of Infectious Disease, Imperial College London, London, UK; NIHR BRC Imperial College NHS Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Van+Doorn+R%22">Van Doorn R</searchLink>; Oxford University Clinical Research Unit (OUCRU), Hanoi, Viet Nam; Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Rahman+M%22">Rahman M</searchLink>; Oxford University Clinical Research Unit (OUCRU), Ho Chi Minh City, Viet Nam.<br /><searchLink fieldCode="AU" term="%22Pett+SL%22">Pett SL</searchLink>; MRC Clinical Trial Unit at UCL, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Thwaites+GE%22">Thwaites GE</searchLink>; Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam; Oxford University Clinical Research Unit (OUCRU), Ho Chi Minh City, Viet Nam; Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Barnes+E%22">Barnes E</searchLink>; Nuffield Department of Medicine, University of Oxford, Oxford, UK; NIHR BRC Oxford University NHS Trust, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Day+JN%22">Day JN</searchLink>; Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam; Oxford University Clinical Research Unit (OUCRU), Ho Chi Minh City, Viet Nam; Department of Clinical Microbiology and Infection, Royal Devon University Healthcare, Exeter, UK.<br /><searchLink fieldCode="AU" term="%22Chau+NVV%22">Chau NVV</searchLink>; Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam.<br /><searchLink fieldCode="AU" term="%22Walker+AS%22">Walker AS</searchLink>; MRC Clinical Trial Unit at UCL, University College London, London, UK.
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  Data: <searchLink fieldCode="JN" term="%222985213R%22">Lancet (London, England)</searchLink> [Lancet] 2025 May 17; Vol. 405 (10491), pp. 1769-1780. <i>Date of Electronic Publication: </i>2025 May 08.
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