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Bile acid-FXR signaling facilitates the long-term maintenance of hepatic characteristics in human iPSC-derived organoids.

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Title: Bile acid-FXR signaling facilitates the long-term maintenance of hepatic characteristics in human iPSC-derived organoids.
Authors: Shimizu T; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo 1138519, Japan., Miyoshi M; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo 1138519, Japan., Kakinuma S; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo 1138519, Japan; Department of Clinical and Diagnostic Laboratory Science, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo 1138519, Japan. Electronic address: skakinuma.gast@tmd.ac.jp., Tsuchiya J; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo 1138519, Japan., Yamane D; Department of Diseases and Infection, Tokyo Metropolitan Institute of Medical Science, Tokyo 1568506, Japan., Watakabe K; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo 1138519, Japan., Mochida T; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo 1138519, Japan., Inada K; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo 1138519, Japan., Yamada K; Department of Clinical and Diagnostic Laboratory Science, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo 1138519, Japan., Shinozaki K; Department of Diseases and Infection, Tokyo Metropolitan Institute of Medical Science, Tokyo 1568506, Japan., Sato A; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo 1138519, Japan., Kaneko S; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo 1138519, Japan., Kawai-Kitahata F; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo 1138519, Japan., Murakawa M; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo 1138519, Japan., Nitta S; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo 1138519, Japan., Nakagawa M; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo 1138519, Japan., Watanabe M; School of Medicine, Juntendo University, Tokyo 1138421, Japan., Asahina Y; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo 1138519, Japan; Division of Hepatic Medical Science, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo 1138519, Japan. Electronic address: asahina.gast@tmd.ac.jp., Okamoto R; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo 1138519, Japan.
Source: Cell reports [Cell Rep] 2025 May 27; Vol. 44 (5), pp. 115675. Date of Electronic Publication: 2025 May 13.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
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  Data: Bile acid-FXR signaling facilitates the long-term maintenance of hepatic characteristics in human iPSC-derived organoids.
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  Data: <searchLink fieldCode="AU" term="%22Shimizu+T%22">Shimizu T</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo 1138519, Japan.<br /><searchLink fieldCode="AU" term="%22Miyoshi+M%22">Miyoshi M</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo 1138519, Japan.<br /><searchLink fieldCode="AU" term="%22Kakinuma+S%22">Kakinuma S</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo 1138519, Japan; Department of Clinical and Diagnostic Laboratory Science, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo 1138519, Japan. Electronic address: skakinuma.gast@tmd.ac.jp.<br /><searchLink fieldCode="AU" term="%22Tsuchiya+J%22">Tsuchiya J</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo 1138519, Japan.<br /><searchLink fieldCode="AU" term="%22Yamane+D%22">Yamane D</searchLink>; Department of Diseases and Infection, Tokyo Metropolitan Institute of Medical Science, Tokyo 1568506, Japan.<br /><searchLink fieldCode="AU" term="%22Watakabe+K%22">Watakabe K</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo 1138519, Japan.<br /><searchLink fieldCode="AU" term="%22Mochida+T%22">Mochida T</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo 1138519, Japan.<br /><searchLink fieldCode="AU" term="%22Inada+K%22">Inada K</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo 1138519, Japan.<br /><searchLink fieldCode="AU" term="%22Yamada+K%22">Yamada K</searchLink>; Department of Clinical and Diagnostic Laboratory Science, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo 1138519, Japan.<br /><searchLink fieldCode="AU" term="%22Shinozaki+K%22">Shinozaki K</searchLink>; Department of Diseases and Infection, Tokyo Metropolitan Institute of Medical Science, Tokyo 1568506, Japan.<br /><searchLink fieldCode="AU" term="%22Sato+A%22">Sato A</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo 1138519, Japan.<br /><searchLink fieldCode="AU" term="%22Kaneko+S%22">Kaneko S</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo 1138519, Japan.<br /><searchLink fieldCode="AU" term="%22Kawai-Kitahata+F%22">Kawai-Kitahata F</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo 1138519, Japan.<br /><searchLink fieldCode="AU" term="%22Murakawa+M%22">Murakawa M</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo 1138519, Japan.<br /><searchLink fieldCode="AU" term="%22Nitta+S%22">Nitta S</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo 1138519, Japan.<br /><searchLink fieldCode="AU" term="%22Nakagawa+M%22">Nakagawa M</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo 1138519, Japan.<br /><searchLink fieldCode="AU" term="%22Watanabe+M%22">Watanabe M</searchLink>; School of Medicine, Juntendo University, Tokyo 1138421, Japan.<br /><searchLink fieldCode="AU" term="%22Asahina+Y%22">Asahina Y</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo 1138519, Japan; Division of Hepatic Medical Science, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo 1138519, Japan. Electronic address: asahina.gast@tmd.ac.jp.<br /><searchLink fieldCode="AU" term="%22Okamoto+R%22">Okamoto R</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Institute of Science Tokyo (Science Tokyo), Tokyo 1138519, Japan.
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  Data: <searchLink fieldCode="JN" term="%22101573691%22">Cell reports</searchLink> [Cell Rep] 2025 May 27; Vol. 44 (5), pp. 115675. <i>Date of Electronic Publication: </i>2025 May 13.
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