Radiation-induced amphiregulin drives tumour metastasis.

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Title: Radiation-induced amphiregulin drives tumour metastasis.
Authors: Piffkó A; Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, USA.; The Ludwig Center for Metastasis Research, University of Chicago, Chicago, IL, USA.; Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Yang K; Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, USA.; The Ludwig Center for Metastasis Research, University of Chicago, Chicago, IL, USA.; School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, P. R. China., Panda A; Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, University of Chicago, Chicago, IL, USA.; Howard Hughes Medical Institute, University of Chicago, Chicago, IL, USA., Heide J; Department of Obstetrics and Gynecology/Section Gynecologic Oncology, University of Chicago, Chicago, IL, USA., Tesak K; Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, USA.; The Ludwig Center for Metastasis Research, University of Chicago, Chicago, IL, USA.; Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, University of Chicago, Chicago, IL, USA., Wen C; Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, USA.; The Ludwig Center for Metastasis Research, University of Chicago, Chicago, IL, USA., Zawieracz K; Department of Pathology, Section of Hematology/Oncology, University of Chicago, Chicago, IL, USA., Wang L; Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, USA.; The Ludwig Center for Metastasis Research, University of Chicago, Chicago, IL, USA.; The Laboratory of Microbiome and Microecological Technology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, P. R. China., Naccasha EZ; Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, USA.; The Ludwig Center for Metastasis Research, University of Chicago, Chicago, IL, USA., Bugno J; Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, USA.; The Ludwig Center for Metastasis Research, University of Chicago, Chicago, IL, USA.; Committee on Clinical Pharmacology and Pharmacogenomics, University of Chicago, Chicago, IL, USA., Fu Y; Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, USA.; The Ludwig Center for Metastasis Research, University of Chicago, Chicago, IL, USA.; Drukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA., Chen D; Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, USA.; The Ludwig Center for Metastasis Research, University of Chicago, Chicago, IL, USA., Donle L; Department of Obstetrics and Gynecology/Section Gynecologic Oncology, University of Chicago, Chicago, IL, USA., Lengyel E; Department of Obstetrics and Gynecology/Section Gynecologic Oncology, University of Chicago, Chicago, IL, USA., Tilley DG; Department of Cardiovascular Sciences, Temple University, Philadelphia, PA, USA., Mack M; Department of Internal Medicine, University of Regensburg, Regensburg, Germany., Rock RS; Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, University of Chicago, Chicago, IL, USA., Chmura SJ; Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, USA.; The Ludwig Center for Metastasis Research, University of Chicago, Chicago, IL, USA., Vokes EE; Department of Medicine, University of Chicago, Chicago, IL, USA., He C; Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, University of Chicago, Chicago, IL, USA.; Howard Hughes Medical Institute, University of Chicago, Chicago, IL, USA., Pitroda SP; Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, USA.; The Ludwig Center for Metastasis Research, University of Chicago, Chicago, IL, USA., Liang HL; Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, USA.; The Ludwig Center for Metastasis Research, University of Chicago, Chicago, IL, USA., Weichselbaum RR; Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, USA. ralph.weichselbaum@uchospitals.edu.; The Ludwig Center for Metastasis Research, University of Chicago, Chicago, IL, USA. ralph.weichselbaum@uchospitals.edu.
Source: Nature [Nature] 2025 Jul; Vol. 643 (8072), pp. 810-819. Date of Electronic Publication: 2025 May 14.
Publication Type: Journal Article; Clinical Trial; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-4687
DOI:10.1038/s41586-025-08994-0