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Small-molecule dissolution of stress granules by redox modulation benefits ALS models.

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Title: Small-molecule dissolution of stress granules by redox modulation benefits ALS models.
Authors: Uechi H; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.; Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, Japan., Sridharan S; Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Nijssen J; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany., Bilstein J; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.; Faculty of Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Iglesias-Artola JM; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany., Kishigami S; Department of Chemistry, University of Oxford, Oxford, UK.; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK., Casablancas-Antras V; Department of Chemistry, University of Oxford, Oxford, UK.; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK., Poser I; Dewpoint Therapeutics, Dresden, Germany., Martinez EJ; Dewpoint Therapeutics, Boston, MA, USA., Boczek E; Dewpoint Therapeutics, Dresden, Germany., Wagner M; Dewpoint Therapeutics, Dresden, Germany., Tomschke N; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany., de Jesus Domingues AM; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.; Dewpoint Therapeutics, Dresden, Germany., Pal A; Department of Neurology, Technische Universität Dresden, Dresden, Germany.; Dresden High Magnetic Field Laboratory (HLD), Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany., Doeleman T; Department of Neurology, Technische Universität Dresden, Dresden, Germany., Kour S; Division of Child Neurology, Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.; Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Anderson EN; Division of Child Neurology, Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.; Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Stein F; Proteomics Core Facility, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany., Lee HO; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada., Zhang X; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.; iHuman Institute, School of Life Science and Technology, ShanghaiTech University, Shanghai, China., Fritsch AW; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany., Jahnel M; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.; Cluster of Excellence Physics of Life, TU Dresden, Dresden, Germany.; Biotechnology Center (BIOTEC), CMCB, TU Dresden, Dresden, Germany., Fürsch J; University of Konstanz, Department of Biology, Konstanz, Germany.; Konstanz Research School Chemical Biology, University of Konstanz, Konstanz, Germany., Murthy AC; Graduate Program in Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI, USA., Alberti S; Biotechnology Center (BIOTEC), CMCB, TU Dresden, Dresden, Germany., Bickle M; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.; Institute for Translational Bioengineering, pRED, Roche, Basel, Switzerland., Fawzi NL; Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI, USA., Nadler A; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany., David DC; German Centre for Neurodegenerative Diseases, Tübingen, Germany.; Babraham Institute, Cambridge, UK., Pandey UB; Division of Child Neurology, Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.; Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Hermann A; Department of Neurology, Technische Universität Dresden, Dresden, Germany.; Center for Regenerative Therapies TU Dresden (CRTD), Technische Universität Dresden, Dresden, Germany.; Center for Transdisciplinary Neurosciences Rostock (CTNR), University Medical Center Rostock, University of Rostock, Rostock, Germany.; Translational Neurodegeneration Section 'Albrecht Kossel', Department of Neurology, University Medical Center Rostock, Rostock, Germany.; Deutsches Zentrum für Neurodegenerative (DZNE) Rostock/Greifswald, Rostock, Germany., Stengel F; University of Konstanz, Department of Biology, Konstanz, Germany.; Konstanz Research School Chemical Biology, University of Konstanz, Konstanz, Germany., Davis BG; Department of Chemistry, University of Oxford, Oxford, UK.; Department of Pharmacology, University of Oxford, Oxford, UK.; The Rosalind Franklin Institute, Harwell, UK., Baldwin AJ; Department of Chemistry, University of Oxford, Oxford, UK.; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.; The Rosalind Franklin Institute, Harwell, UK., Savitski MM; Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Hyman AA; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany. hyman@mpi-cbg.de., Wheeler RJ; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany. r.wheeler@ed.ac.uk.; Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Ashworth Laboratories, Edinburgh, UK. r.wheeler@ed.ac.uk.; Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK. r.wheeler@ed.ac.uk.
Source: Nature chemical biology [Nat Chem Biol] 2025 Oct; Vol. 21 (10), pp. 1577-1588. Date of Electronic Publication: 2025 May 14.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE
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