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ANP32E drives vulnerability to ATR inhibitors by inducing R-loops-dependent transcription replication conflicts in triple negative breast cancer.

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Title: ANP32E drives vulnerability to ATR inhibitors by inducing R-loops-dependent transcription replication conflicts in triple negative breast cancer.
Authors: Lago S; Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123, Trento, Italy., Poli V; Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123, Trento, Italy., Fol L; Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123, Trento, Italy.; Institute of Molecular Biology (IMB), Mainz, Germany., Botteon M; Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123, Trento, Italy., Busi F; Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123, Trento, Italy., Turdo A; Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Palermo, Italy., Gaggianesi M; Department of Precision Medicine in Medical, Surgical and Critical Care, University of Palermo, 90127, Palermo, Italy., Ciani Y; Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123, Trento, Italy., D'Amato G; Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123, Trento, Italy., Fagnocchi L; Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123, Trento, Italy., Fasciani A; Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123, Trento, Italy., Demichelis F; Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123, Trento, Italy., Todaro M; Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Palermo, Italy., Zippo A; Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123, Trento, Italy. alessio.zippo@unitn.it.
Source: Nature communications [Nat Commun] 2025 May 17; Vol. 16 (1), pp. 4602. Date of Electronic Publication: 2025 May 17.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: ANP32E drives vulnerability to ATR inhibitors by inducing R-loops-dependent transcription replication conflicts in triple negative breast cancer.
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  Data: <searchLink fieldCode="AU" term="%22Lago+S%22">Lago S</searchLink>; Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123, Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Poli+V%22">Poli V</searchLink>; Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123, Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Fol+L%22">Fol L</searchLink>; Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123, Trento, Italy.; Institute of Molecular Biology (IMB), Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Botteon+M%22">Botteon M</searchLink>; Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123, Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Busi+F%22">Busi F</searchLink>; Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123, Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Turdo+A%22">Turdo A</searchLink>; Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Palermo, Italy.<br /><searchLink fieldCode="AU" term="%22Gaggianesi+M%22">Gaggianesi M</searchLink>; Department of Precision Medicine in Medical, Surgical and Critical Care, University of Palermo, 90127, Palermo, Italy.<br /><searchLink fieldCode="AU" term="%22Ciani+Y%22">Ciani Y</searchLink>; Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123, Trento, Italy.<br /><searchLink fieldCode="AU" term="%22D'Amato+G%22">D'Amato G</searchLink>; Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123, Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Fagnocchi+L%22">Fagnocchi L</searchLink>; Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123, Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Fasciani+A%22">Fasciani A</searchLink>; Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123, Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Demichelis+F%22">Demichelis F</searchLink>; Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123, Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Todaro+M%22">Todaro M</searchLink>; Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Palermo, Italy.<br /><searchLink fieldCode="AU" term="%22Zippo+A%22">Zippo A</searchLink>; Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123, Trento, Italy. alessio.zippo@unitn.it.
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