Type I interferon drives T cell cytotoxicity by upregulation of interferon regulatory factor 7 in autoimmune kidney diseases in mice.

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Title: Type I interferon drives T cell cytotoxicity by upregulation of interferon regulatory factor 7 in autoimmune kidney diseases in mice.
Authors: Wang H; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Engesser J; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Khatri R; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Institute of Medical Systems Biology, Center for Biomedical AI (bAIome), Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Schaub DP; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Institute of Medical Systems Biology, Center for Biomedical AI (bAIome), Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Paust HJ; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Sultana Z; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Institute of Medical Systems Biology, Center for Biomedical AI (bAIome), Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Jauch-Speer SL; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Peters A; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Kaffke A; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Bonn S; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Institute of Medical Systems Biology, Center for Biomedical AI (bAIome), Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Haburg Center for Kidney Health, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Huber TB; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Haburg Center for Kidney Health, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Mittrücker HW; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Institute for Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Krebs CF; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Haburg Center for Kidney Health, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Panzer U; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. panzer@uke.uni-hamburg.de.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. panzer@uke.uni-hamburg.de.; Haburg Center for Kidney Health, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. panzer@uke.uni-hamburg.de., Asada N; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. n.asada@uke.de.; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. n.asada@uke.de.
Source: Nature communications [Nat Commun] 2025 May 20; Vol. 16 (1), pp. 4686. Date of Electronic Publication: 2025 May 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-59819-7