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ctDNA and Recurrence Risk for Adjuvant De-Escalation in HPV-Positive Oropharyngeal Carcinoma: A Secondary Analysis of the DART Phase 3 Randomized Clinical Trial.

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Title: ctDNA and Recurrence Risk for Adjuvant De-Escalation in HPV-Positive Oropharyngeal Carcinoma: A Secondary Analysis of the DART Phase 3 Randomized Clinical Trial.
Authors: Routman DM; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota., Van Abel KM; Department of Otolaryngology, Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota., Price KA; Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota., Moore EJ; Department of Otolaryngology, Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota., Patel SH; Department of Radiation Oncology, Mayo Clinic, Phoenix, Arizona., Hinni ML; Department of Otolaryngology, Mayo Clinic, Phoenix, Arizona., Fruth B; Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota., Foster NR; Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota., Yin LX; Department of Otolaryngology, Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota., Neben-Wittich M; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota., Garces YI; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota., McGee LA; Department of Radiation Oncology, Mayo Clinic, Phoenix, Arizona., Lester SC; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota., Gamez ME; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota., Rwigema JM; Department of Radiation Oncology, Mayo Clinic, Phoenix, Arizona., Holtzman AL; Department of Radiation Oncology, Mayo Clinic, Jacksonville, Florida., Price DL; Department of Otolaryngology, Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota., Janus JR; Department of Otolaryngology, Head and Neck Surgery, Mayo Clinic, Jacksonville, Florida., Kasperbauer JL; Department of Otolaryngology, Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota., Chintakuntlawar AV; Division of Medical Oncology, Mayo Clinic, Phoenix, Arizona., Garcia JJ; Department of Laboratory Medicine & Pathology, Mayo Clinic, Rochester, Minnesota., Foote RL; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota., Ma DJ; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.
Source: JAMA otolaryngology-- head & neck surgery [JAMA Otolaryngol Head Neck Surg] 2025 Jul 01; Vol. 151 (7), pp. 665-672.
Publication Type: Clinical Trial, Phase III; Journal Article; Randomized Controlled Trial
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101589542 Publication Model: Print Cited Medium: Internet ISSN: 2168-619X (Electronic) Linking ISSN: 21686181 NLM ISO Abbreviation: JAMA Otolaryngol Head Neck Surg Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: ctDNA and Recurrence Risk for Adjuvant De-Escalation in HPV-Positive Oropharyngeal Carcinoma: A Secondary Analysis of the DART Phase 3 Randomized Clinical Trial.
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  Data: <searchLink fieldCode="AU" term="%22Routman+DM%22">Routman DM</searchLink>; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Van+Abel+KM%22">Van Abel KM</searchLink>; Department of Otolaryngology, Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Price+KA%22">Price KA</searchLink>; Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Moore+EJ%22">Moore EJ</searchLink>; Department of Otolaryngology, Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Patel+SH%22">Patel SH</searchLink>; Department of Radiation Oncology, Mayo Clinic, Phoenix, Arizona.<br /><searchLink fieldCode="AU" term="%22Hinni+ML%22">Hinni ML</searchLink>; Department of Otolaryngology, Mayo Clinic, Phoenix, Arizona.<br /><searchLink fieldCode="AU" term="%22Fruth+B%22">Fruth B</searchLink>; Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Foster+NR%22">Foster NR</searchLink>; Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Yin+LX%22">Yin LX</searchLink>; Department of Otolaryngology, Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Neben-Wittich+M%22">Neben-Wittich M</searchLink>; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Garces+YI%22">Garces YI</searchLink>; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22McGee+LA%22">McGee LA</searchLink>; Department of Radiation Oncology, Mayo Clinic, Phoenix, Arizona.<br /><searchLink fieldCode="AU" term="%22Lester+SC%22">Lester SC</searchLink>; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Gamez+ME%22">Gamez ME</searchLink>; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Rwigema+JM%22">Rwigema JM</searchLink>; Department of Radiation Oncology, Mayo Clinic, Phoenix, Arizona.<br /><searchLink fieldCode="AU" term="%22Holtzman+AL%22">Holtzman AL</searchLink>; Department of Radiation Oncology, Mayo Clinic, Jacksonville, Florida.<br /><searchLink fieldCode="AU" term="%22Price+DL%22">Price DL</searchLink>; Department of Otolaryngology, Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Janus+JR%22">Janus JR</searchLink>; Department of Otolaryngology, Head and Neck Surgery, Mayo Clinic, Jacksonville, Florida.<br /><searchLink fieldCode="AU" term="%22Kasperbauer+JL%22">Kasperbauer JL</searchLink>; Department of Otolaryngology, Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Chintakuntlawar+AV%22">Chintakuntlawar AV</searchLink>; Division of Medical Oncology, Mayo Clinic, Phoenix, Arizona.<br /><searchLink fieldCode="AU" term="%22Garcia+JJ%22">Garcia JJ</searchLink>; Department of Laboratory Medicine & Pathology, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Foote+RL%22">Foote RL</searchLink>; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Ma+DJ%22">Ma DJ</searchLink>; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.
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  Data: <searchLink fieldCode="JN" term="%22101589542%22">JAMA otolaryngology-- head & neck surgery</searchLink> [JAMA Otolaryngol Head Neck Surg] 2025 Jul 01; Vol. 151 (7), pp. 665-672.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Medical+Association%22">American Medical Association </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101589542 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>2168-619X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2221686181%22">21686181 </searchLink><i>NLM ISO Abbreviation: </i>JAMA Otolaryngol Head Neck Surg <i>Subsets: </i>MEDLINE
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