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The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia xenografted into a mouse model of Alzheimer's disease.

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Title: The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia xenografted into a mouse model of Alzheimer's disease.
Authors: Murphy KB; UK Dementia Research Institute at Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Hu D; UK Dementia Research Institute at Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK., Wolfs L; VIB Center for Brain & Disease Research, VIB, Leuven, Belgium.; Department of Neurosciences and Leuven Brain Institute, KU Leuven, Leuven, Belgium., Rohde SK; VIB Center for Brain & Disease Research, VIB, Leuven, Belgium.; Department of Neurosciences and Leuven Brain Institute, KU Leuven, Leuven, Belgium., Fauró GL; VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium., Geric I; VIB Center for Brain & Disease Research, VIB, Leuven, Belgium.; Department of Neurosciences and Leuven Brain Institute, KU Leuven, Leuven, Belgium., Mancuso R; VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium., De Strooper B; VIB Center for Brain & Disease Research, VIB, Leuven, Belgium.; Department of Neurosciences and Leuven Brain Institute, KU Leuven, Leuven, Belgium.; UK Dementia Research Institute at University College London, London, UK., Marzi SJ; Department of Brain Sciences, Imperial College London, London, UK. sarah.marzi@kcl.ac.uk.; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. sarah.marzi@kcl.ac.uk.; UK Dementia Research Institute at King's College London, London, UK. sarah.marzi@kcl.ac.uk.
Source: Nature communications [Nat Commun] 2025 May 27; Vol. 16 (1), pp. 4883. Date of Electronic Publication: 2025 May 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia xenografted into a mouse model of Alzheimer's disease.
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  Data: <searchLink fieldCode="AU" term="%22Murphy+KB%22">Murphy KB</searchLink>; UK Dementia Research Institute at Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Hu+D%22">Hu D</searchLink>; UK Dementia Research Institute at Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Wolfs+L%22">Wolfs L</searchLink>; VIB Center for Brain & Disease Research, VIB, Leuven, Belgium.; Department of Neurosciences and Leuven Brain Institute, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Rohde+SK%22">Rohde SK</searchLink>; VIB Center for Brain & Disease Research, VIB, Leuven, Belgium.; Department of Neurosciences and Leuven Brain Institute, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Fauró+GL%22">Fauró GL</searchLink>; VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Geric+I%22">Geric I</searchLink>; VIB Center for Brain & Disease Research, VIB, Leuven, Belgium.; Department of Neurosciences and Leuven Brain Institute, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Mancuso+R%22">Mancuso R</searchLink>; VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22De+Strooper+B%22">De Strooper B</searchLink>; VIB Center for Brain & Disease Research, VIB, Leuven, Belgium.; Department of Neurosciences and Leuven Brain Institute, KU Leuven, Leuven, Belgium.; UK Dementia Research Institute at University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Marzi+SJ%22">Marzi SJ</searchLink>; Department of Brain Sciences, Imperial College London, London, UK. sarah.marzi@kcl.ac.uk.; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. sarah.marzi@kcl.ac.uk.; UK Dementia Research Institute at King's College London, London, UK. sarah.marzi@kcl.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 May 27; Vol. 16 (1), pp. 4883. <i>Date of Electronic Publication: </i>2025 May 27.
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              Text: 2025 May 27
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