The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia xenografted into a mouse model of Alzheimer's disease.
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| Title: | The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia xenografted into a mouse model of Alzheimer's disease. |
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| Authors: | Murphy KB; UK Dementia Research Institute at Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK.; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Hu D; UK Dementia Research Institute at Imperial College London, London, UK.; Department of Brain Sciences, Imperial College London, London, UK., Wolfs L; VIB Center for Brain & Disease Research, VIB, Leuven, Belgium.; Department of Neurosciences and Leuven Brain Institute, KU Leuven, Leuven, Belgium., Rohde SK; VIB Center for Brain & Disease Research, VIB, Leuven, Belgium.; Department of Neurosciences and Leuven Brain Institute, KU Leuven, Leuven, Belgium., Fauró GL; VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium., Geric I; VIB Center for Brain & Disease Research, VIB, Leuven, Belgium.; Department of Neurosciences and Leuven Brain Institute, KU Leuven, Leuven, Belgium., Mancuso R; VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium., De Strooper B; VIB Center for Brain & Disease Research, VIB, Leuven, Belgium.; Department of Neurosciences and Leuven Brain Institute, KU Leuven, Leuven, Belgium.; UK Dementia Research Institute at University College London, London, UK., Marzi SJ; Department of Brain Sciences, Imperial College London, London, UK. sarah.marzi@kcl.ac.uk.; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. sarah.marzi@kcl.ac.uk.; UK Dementia Research Institute at King's College London, London, UK. sarah.marzi@kcl.ac.uk. |
| Source: | Nature communications [Nat Commun] 2025 May 27; Vol. 16 (1), pp. 4883. Date of Electronic Publication: 2025 May 27. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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