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T cell responses towards PINK1 and α-synuclein are elevated in prodromal Parkinson's disease.

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Title: T cell responses towards PINK1 and α-synuclein are elevated in prodromal Parkinson's disease.
Authors: Johansson E; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.; Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, Lund University, Lund, Sweden., Freuchet A; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA., Williams GP; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA., Michealis T; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA., Frazier A; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA., Litvan I; Department of Neuroscience, University of California San Diego, La Jolla, CA, USA., Goldman JG; JPG Enterprises LLC (prior: Shirley Ryan Ability Lab and Northwestern University Feinberg School of Medicine), Chicago, IL, USA., Alcalay RN; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.; Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Standaert DG; Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA., Amara AW; Department of Neurology, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA., Stover N; Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA., Fon EA; Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada., Postuma RB; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, QC, H3A 2B4, Canada., Sidney J; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA., Sulzer D; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.; Departments of Psychiatry, Pharmacology and Neurology, Columbia University, New York, NY, USA.; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY, USA., Lindestam Arlehamn CS; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.; Center for Vaccine Research, Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark., Sette A; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA. alex@lji.org.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA. alex@lji.org.; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California San Diego, La Jolla, CA, USA. alex@lji.org.
Source: NPJ Parkinson's disease [NPJ Parkinsons Dis] 2025 May 26; Vol. 11 (1), pp. 137. Date of Electronic Publication: 2025 May 26.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101675390 Publication Model: Electronic Cited Medium: Print ISSN: 2373-8057 (Print) Linking ISSN: 23738057 NLM ISO Abbreviation: NPJ Parkinsons Dis Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: T cell responses towards PINK1 and α-synuclein are elevated in prodromal Parkinson's disease.
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  Data: <searchLink fieldCode="AU" term="%22Johansson+E%22">Johansson E</searchLink>; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.; Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Freuchet+A%22">Freuchet A</searchLink>; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.<br /><searchLink fieldCode="AU" term="%22Williams+GP%22">Williams GP</searchLink>; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.<br /><searchLink fieldCode="AU" term="%22Michealis+T%22">Michealis T</searchLink>; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.<br /><searchLink fieldCode="AU" term="%22Frazier+A%22">Frazier A</searchLink>; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.<br /><searchLink fieldCode="AU" term="%22Litvan+I%22">Litvan I</searchLink>; Department of Neuroscience, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Goldman+JG%22">Goldman JG</searchLink>; JPG Enterprises LLC (prior: Shirley Ryan Ability Lab and Northwestern University Feinberg School of Medicine), Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Alcalay+RN%22">Alcalay RN</searchLink>; Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.; Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Standaert+DG%22">Standaert DG</searchLink>; Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Amara+AW%22">Amara AW</searchLink>; Department of Neurology, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Stover+N%22">Stover N</searchLink>; Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Fon+EA%22">Fon EA</searchLink>; Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada.<br /><searchLink fieldCode="AU" term="%22Postuma+RB%22">Postuma RB</searchLink>; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, QC, H3A 2B4, Canada.<br /><searchLink fieldCode="AU" term="%22Sidney+J%22">Sidney J</searchLink>; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Sulzer+D%22">Sulzer D</searchLink>; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.; Departments of Psychiatry, Pharmacology and Neurology, Columbia University, New York, NY, USA.; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lindestam+Arlehamn+CS%22">Lindestam Arlehamn CS</searchLink>; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.; Center for Vaccine Research, Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Sette+A%22">Sette A</searchLink>; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA. alex@lji.org.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA. alex@lji.org.; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California San Diego, La Jolla, CA, USA. alex@lji.org.
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  Data: <searchLink fieldCode="JN" term="%22101675390%22">NPJ Parkinson's disease</searchLink> [NPJ Parkinsons Dis] 2025 May 26; Vol. 11 (1), pp. 137. <i>Date of Electronic Publication: </i>2025 May 26.
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