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Radiomic and proteomic signatures of body mass index on brain ageing and Alzheimer's-like patterns of brain atrophy.

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Title: Radiomic and proteomic signatures of body mass index on brain ageing and Alzheimer's-like patterns of brain atrophy.
Authors: Anagnostakis F; Department of Medical and Surgical Sciences, Alma Mater University of Bologna, Bologna, Italy; Centre for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: filippos.anagnostakis@pennmedicine.upenn.edu., Kokkorakis M; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Walker KA; Laboratory of Behavioral Neuroscience, National Institute on Aging, Intramural Research Program, Baltimore, MD, USA., Skampardoni I; Centre for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA., Wen J; Laboratory of AI and Biomedical Science (LABS), Columbia University, New York, NY, USA., Erus G; Centre for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA., Tosun D; Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA., Tassopoulou V; Centre for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA., Cui Y; Centre for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA., Govindarajan ST; Centre for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA., Srinivasan D; Centre for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA., Melhem R; Centre for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA., Mamourian E; Centre for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA., Shou H; Centre for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA., Nasrallah IM; Centre for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA; Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA., Mantzoros CS; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Section of Endocrinology, Boston VA Healthcare System, Harvard Medical School, Boston, MA, USA., Davatzikos C; Centre for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: Christos.davatzikos@pennmedicine.upenn.edu.
Source: EBioMedicine [EBioMedicine] 2025 Jun; Vol. 116, pp. 105763. Date of Electronic Publication: 2025 May 27.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101647039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3964 (Electronic) Linking ISSN: 23523964 NLM ISO Abbreviation: EBioMedicine Subsets: MEDLINE
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  Data: Radiomic and proteomic signatures of body mass index on brain ageing and Alzheimer's-like patterns of brain atrophy.
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  Data: <searchLink fieldCode="AU" term="%22Anagnostakis+F%22">Anagnostakis F</searchLink>; Department of Medical and Surgical Sciences, Alma Mater University of Bologna, Bologna, Italy; Centre for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: filippos.anagnostakis@pennmedicine.upenn.edu.<br /><searchLink fieldCode="AU" term="%22Kokkorakis+M%22">Kokkorakis M</searchLink>; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Walker+KA%22">Walker KA</searchLink>; Laboratory of Behavioral Neuroscience, National Institute on Aging, Intramural Research Program, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Skampardoni+I%22">Skampardoni I</searchLink>; Centre for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Wen+J%22">Wen J</searchLink>; Laboratory of AI and Biomedical Science (LABS), Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Erus+G%22">Erus G</searchLink>; Centre for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Tosun+D%22">Tosun D</searchLink>; Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA.<br /><searchLink fieldCode="AU" term="%22Tassopoulou+V%22">Tassopoulou V</searchLink>; Centre for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Cui+Y%22">Cui Y</searchLink>; Centre for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Govindarajan+ST%22">Govindarajan ST</searchLink>; Centre for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Srinivasan+D%22">Srinivasan D</searchLink>; Centre for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Melhem+R%22">Melhem R</searchLink>; Centre for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Mamourian+E%22">Mamourian E</searchLink>; Centre for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Shou+H%22">Shou H</searchLink>; Centre for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Nasrallah+IM%22">Nasrallah IM</searchLink>; Centre for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA; Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Mantzoros+CS%22">Mantzoros CS</searchLink>; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Section of Endocrinology, Boston VA Healthcare System, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Davatzikos+C%22">Davatzikos C</searchLink>; Centre for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: Christos.davatzikos@pennmedicine.upenn.edu.
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