Precision targeting of β-catenin induces tumor reprogramming and immunity in hepatocellular cancers.
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| Title: | Precision targeting of β-catenin induces tumor reprogramming and immunity in hepatocellular cancers. |
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| Authors: | Lehrich BM; Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA.; Medical Scientist Training Program, University of Pittsburgh, Pittsburgh, PA, USA., Delgado ER; Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA.; Department of Pathology, Division of Experimental Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Yasaka TM; Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA.; Medical Scientist Training Program, University of Pittsburgh, Pittsburgh, PA, USA., Liu S; Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Cao C; Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Liu Y; Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Taheri MN; Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA.; Department of Pathology, Division of Experimental Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA., Guan X; Translational Medicine, Genentech Inc., San Francisco, CA, USA., Koeppen H; Translational Medicine, Genentech Inc., San Francisco, CA, USA., Singh S; Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Meadows V; Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Liu JJ; Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Singh-Varma A; Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Krutsenko Y; Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Poddar M; Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Hitchens TK; University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Foley LM; University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Liang B; Hepatic Surgery Center, Department of Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Rialdi A; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Rai RP; Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Patel P; Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Riley M; Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Bell A; Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Raeman R; Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Dadali T; Alnylam Pharmaceuticals, Boston, MA, USA., Luke JJ; UPMC Hillman Cancer Center and University of Pittsburgh, Pittsburgh, PA, USA., Guccione E; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ebrahimkhani MR; Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA.; Department of Pathology, Division of Experimental Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA., Lujambio A; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Chen X; Cancer Biology Program, University of Hawaii Cancer Center, Honolulu, HI, USA., Maier M; Alnylam Pharmaceuticals, Boston, MA, USA., Wang Y; Translational Medicine, Genentech Inc., San Francisco, CA, USA., Broom W; Alnylam Pharmaceuticals, Boston, MA, USA., Tao J; Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. junyantao2010@gmail.com.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. junyantao2010@gmail.com.; Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA. junyantao2010@gmail.com., Monga SP; Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. smonga@pitt.edu.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. smonga@pitt.edu.; Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA. smonga@pitt.edu.; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. smonga@pitt.edu. |
| Source: | Nature communications [Nat Commun] 2025 May 30; Vol. 16 (1), pp. 5009. Date of Electronic Publication: 2025 May 30. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40442146 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Precision targeting of β-catenin induces tumor reprogramming and immunity in hepatocellular cancers. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Lehrich+BM%22">Lehrich BM</searchLink>; Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA.; Medical Scientist Training Program, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Delgado+ER%22">Delgado ER</searchLink>; Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA.; Department of Pathology, Division of Experimental Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Yasaka+TM%22">Yasaka TM</searchLink>; Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA.; Medical Scientist Training Program, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Liu+S%22">Liu S</searchLink>; Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Cao+C%22">Cao C</searchLink>; Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Taheri+MN%22">Taheri MN</searchLink>; Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA.; Department of Pathology, Division of Experimental Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Guan+X%22">Guan X</searchLink>; Translational Medicine, Genentech Inc., San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Koeppen+H%22">Koeppen H</searchLink>; Translational Medicine, Genentech Inc., San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Singh+S%22">Singh S</searchLink>; Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Meadows+V%22">Meadows V</searchLink>; Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Liu+JJ%22">Liu JJ</searchLink>; Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Singh-Varma+A%22">Singh-Varma A</searchLink>; Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Krutsenko+Y%22">Krutsenko Y</searchLink>; Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Poddar+M%22">Poddar M</searchLink>; Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Hitchens+TK%22">Hitchens TK</searchLink>; University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Foley+LM%22">Foley LM</searchLink>; University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Liang+B%22">Liang B</searchLink>; Hepatic Surgery Center, Department of Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Rialdi+A%22">Rialdi A</searchLink>; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Rai+RP%22">Rai RP</searchLink>; Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Patel+P%22">Patel P</searchLink>; Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Riley+M%22">Riley M</searchLink>; Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Bell+A%22">Bell A</searchLink>; Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Raeman+R%22">Raeman R</searchLink>; Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Dadali+T%22">Dadali T</searchLink>; Alnylam Pharmaceuticals, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Luke+JJ%22">Luke JJ</searchLink>; UPMC Hillman Cancer Center and University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Guccione+E%22">Guccione E</searchLink>; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ebrahimkhani+MR%22">Ebrahimkhani MR</searchLink>; Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA.; Department of Pathology, Division of Experimental Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Lujambio+A%22">Lujambio A</searchLink>; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; Cancer Biology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.<br /><searchLink fieldCode="AU" term="%22Maier+M%22">Maier M</searchLink>; Alnylam Pharmaceuticals, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Translational Medicine, Genentech Inc., San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Broom+W%22">Broom W</searchLink>; Alnylam Pharmaceuticals, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Tao+J%22">Tao J</searchLink>; Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. junyantao2010@gmail.com.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. junyantao2010@gmail.com.; Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA. junyantao2010@gmail.com.<br /><searchLink fieldCode="AU" term="%22Monga+SP%22">Monga SP</searchLink>; Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. smonga@pitt.edu.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. smonga@pitt.edu.; Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA. smonga@pitt.edu.; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. smonga@pitt.edu. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 May 30; Vol. 16 (1), pp. 5009. <i>Date of Electronic Publication: </i>2025 May 30. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. 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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41467-025-60457-2 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 5009 Titles: – TitleFull: Precision targeting of β-catenin induces tumor reprogramming and immunity in hepatocellular cancers. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Lehrich BM – PersonEntity: Name: NameFull: Delgado ER – PersonEntity: Name: NameFull: Yasaka TM – PersonEntity: Name: NameFull: Liu S – PersonEntity: Name: NameFull: Cao C – PersonEntity: Name: NameFull: Liu Y – PersonEntity: Name: NameFull: Taheri MN – PersonEntity: Name: NameFull: Guan X – PersonEntity: Name: NameFull: Koeppen H – PersonEntity: Name: NameFull: Singh S – PersonEntity: Name: NameFull: Meadows V – PersonEntity: Name: NameFull: Liu JJ – PersonEntity: Name: NameFull: Singh-Varma A – PersonEntity: Name: NameFull: Krutsenko Y – PersonEntity: Name: NameFull: Poddar M – PersonEntity: Name: NameFull: Hitchens TK – PersonEntity: Name: NameFull: Foley LM – PersonEntity: Name: NameFull: Liang B – PersonEntity: Name: NameFull: Rialdi A – PersonEntity: Name: NameFull: Rai RP – PersonEntity: Name: NameFull: Patel P – PersonEntity: Name: NameFull: Riley M – PersonEntity: Name: NameFull: Bell A – PersonEntity: Name: NameFull: Raeman R – PersonEntity: Name: NameFull: Dadali T – PersonEntity: Name: NameFull: Luke JJ – PersonEntity: Name: NameFull: Guccione E – PersonEntity: Name: NameFull: Ebrahimkhani MR – PersonEntity: Name: NameFull: Lujambio A – PersonEntity: Name: NameFull: Chen X – PersonEntity: Name: NameFull: Maier M – PersonEntity: Name: NameFull: Wang Y – PersonEntity: Name: NameFull: Broom W – PersonEntity: Name: NameFull: Tao J – PersonEntity: Name: NameFull: Monga SP IsPartOfRelationships: – BibEntity: Dates: – D: 30 M: 05 Text: 2025 May 30 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 2041-1723 Numbering: – Type: volume Value: 16 – Type: issue Value: 1 Titles: – TitleFull: Nature communications Type: main |
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