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Radiologically isolated syndrome: How could we accurately diagnose a subclinical period of multiple sclerosis?

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Title: Radiologically isolated syndrome: How could we accurately diagnose a subclinical period of multiple sclerosis?
Authors: Vilaseca A; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain., Vidal-Jordana A; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain., Sceppacuercia S; Section of Neuroradiology, Hospital Universitari de Vall d'Hebron, Barcelona, Spain., Calderon W; Section of Neuroradiology, Hospital Universitari de Vall d'Hebron, Barcelona, Spain., Arrambide G; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain., Rio J; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain., Tur C; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain., Rodriguez-Acevedo B; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain., Ariño H; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain., Zabalza A; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain., Cobo-Calvo A; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain., Mongay-Ochoa N; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain., Carbonell-Mirabent P; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain., Pappolla A; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain., Carvajal R; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain., Castilló J; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain., Galan I; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain., Midaglia L; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain., Bollo L; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain., Villacieros-Álvarez J; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain., Auger C; Section of Neuroradiology, Hospital Universitari de Vall d'Hebron, Barcelona, Spain., Sastre-Garriga J; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain., Tintoré M; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.; Universitat de Vic-Central de Catalunya (UVic-UCC), Vic, Spain., Comabella M; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain., Rovira À; Section of Neuroradiology, Hospital Universitari de Vall d'Hebron, Barcelona, Spain., Montalban X; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.; Universitat de Vic-Central de Catalunya (UVic-UCC), Vic, Spain.
Source: Multiple sclerosis (Houndmills, Basingstoke, England) [Mult Scler] 2025 Jun; Vol. 31 (7), pp. 771-781. Date of Electronic Publication: 2025 May 30.
Publication Type: Journal Article
Journal Info: Publisher: SAGE Publications Country of Publication: England NLM ID: 9509185 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-0970 (Electronic) Linking ISSN: 13524585 NLM ISO Abbreviation: Mult Scler Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Radiologically isolated syndrome: How could we accurately diagnose a subclinical period of multiple sclerosis?
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  Data: <searchLink fieldCode="AU" term="%22Vilaseca+A%22">Vilaseca A</searchLink>; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Vidal-Jordana+A%22">Vidal-Jordana A</searchLink>; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Sceppacuercia+S%22">Sceppacuercia S</searchLink>; Section of Neuroradiology, Hospital Universitari de Vall d'Hebron, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Calderon+W%22">Calderon W</searchLink>; Section of Neuroradiology, Hospital Universitari de Vall d'Hebron, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Arrambide+G%22">Arrambide G</searchLink>; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Rio+J%22">Rio J</searchLink>; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Tur+C%22">Tur C</searchLink>; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Rodriguez-Acevedo+B%22">Rodriguez-Acevedo B</searchLink>; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Ariño+H%22">Ariño H</searchLink>; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Zabalza+A%22">Zabalza A</searchLink>; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Cobo-Calvo+A%22">Cobo-Calvo A</searchLink>; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Mongay-Ochoa+N%22">Mongay-Ochoa N</searchLink>; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Carbonell-Mirabent+P%22">Carbonell-Mirabent P</searchLink>; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Pappolla+A%22">Pappolla A</searchLink>; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Carvajal+R%22">Carvajal R</searchLink>; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Castilló+J%22">Castilló J</searchLink>; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Galan+I%22">Galan I</searchLink>; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Midaglia+L%22">Midaglia L</searchLink>; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Bollo+L%22">Bollo L</searchLink>; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Villacieros-Álvarez+J%22">Villacieros-Álvarez J</searchLink>; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Auger+C%22">Auger C</searchLink>; Section of Neuroradiology, Hospital Universitari de Vall d'Hebron, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Sastre-Garriga+J%22">Sastre-Garriga J</searchLink>; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Tintoré+M%22">Tintoré M</searchLink>; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.; Universitat de Vic-Central de Catalunya (UVic-UCC), Vic, Spain.<br /><searchLink fieldCode="AU" term="%22Comabella+M%22">Comabella M</searchLink>; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Rovira+À%22">Rovira À</searchLink>; Section of Neuroradiology, Hospital Universitari de Vall d'Hebron, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Montalban+X%22">Montalban X</searchLink>; Neurology Department and Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitari de Vall d'Hebron, Barcelona, Spain.; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.; Universitat de Vic-Central de Catalunya (UVic-UCC), Vic, Spain.
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  Data: <searchLink fieldCode="JN" term="%229509185%22">Multiple sclerosis (Houndmills, Basingstoke, England)</searchLink> [Mult Scler] 2025 Jun; Vol. 31 (7), pp. 771-781. <i>Date of Electronic Publication: </i>2025 May 30.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22SAGE+Publications%22">SAGE Publications </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9509185 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1477-0970 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213524585%22">13524585 </searchLink><i>NLM ISO Abbreviation: </i>Mult Scler <i>Subsets: </i>MEDLINE
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              Text: 2025 Jun
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