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Simultaneous Determination of Unbound Plasma Concentration of Methotrexate and 7-Hydroxymethotrexate in Children Patients Receiving High-Dose Methotrexate Therapy.

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Title: Simultaneous Determination of Unbound Plasma Concentration of Methotrexate and 7-Hydroxymethotrexate in Children Patients Receiving High-Dose Methotrexate Therapy.
Authors: Dong WC; Department of Pharmacy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, 050051, People's Republic of China.; The School of Medicine, Nankai University, Tianjin, 300071, People's Republic of China., Gao SS; Department of Pharmacy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, 050051, People's Republic of China., Shi B; Department of Orthopaedics, Hebei Medical University Third Hospital, Shijiazhuang, Hebei Province, 050000, People's Republic of China., Li HR; Department of Pharmacy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, 050051, People's Republic of China., Jiang Y; School of Pharmacy, Hebei Medical University, Shijiazhuang, Hebei Province, 050017, People's Republic of China.; Hebei Key Laboratory of Forensic Medicine, Shijiazhuang, Hebei Province, 050017, People's Republic of China., Guo JL; Department of Orthopaedics, Hebei Medical University Third Hospital, Shijiazhuang, Hebei Province, 050000, People's Republic of China., Zhang ZQ; Department of Pharmacy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, 050051, People's Republic of China., Zhang YZ; The School of Medicine, Nankai University, Tianjin, 300071, People's Republic of China.; Department of Orthopaedics, Hebei Medical University Third Hospital, Shijiazhuang, Hebei Province, 050000, People's Republic of China.
Source: Drug design, development and therapy [Drug Des Devel Ther] 2025 May 26; Vol. 19, pp. 4383-4396. Date of Electronic Publication: 2025 May 26 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Dove Press Limited Country of Publication: New Zealand NLM ID: 101475745 Publication Model: eCollection Cited Medium: Internet ISSN: 1177-8881 (Electronic) Linking ISSN: 11778881 NLM ISO Abbreviation: Drug Des Devel Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Simultaneous Determination of Unbound Plasma Concentration of Methotrexate and 7-Hydroxymethotrexate in Children Patients Receiving High-Dose Methotrexate Therapy.
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  Data: <searchLink fieldCode="AU" term="%22Dong+WC%22">Dong WC</searchLink>; Department of Pharmacy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, 050051, People's Republic of China.; The School of Medicine, Nankai University, Tianjin, 300071, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Gao+SS%22">Gao SS</searchLink>; Department of Pharmacy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, 050051, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Shi+B%22">Shi B</searchLink>; Department of Orthopaedics, Hebei Medical University Third Hospital, Shijiazhuang, Hebei Province, 050000, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Li+HR%22">Li HR</searchLink>; Department of Pharmacy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, 050051, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Jiang+Y%22">Jiang Y</searchLink>; School of Pharmacy, Hebei Medical University, Shijiazhuang, Hebei Province, 050017, People's Republic of China.; Hebei Key Laboratory of Forensic Medicine, Shijiazhuang, Hebei Province, 050017, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Guo+JL%22">Guo JL</searchLink>; Department of Orthopaedics, Hebei Medical University Third Hospital, Shijiazhuang, Hebei Province, 050000, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Zhang+ZQ%22">Zhang ZQ</searchLink>; Department of Pharmacy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, 050051, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Zhang+YZ%22">Zhang YZ</searchLink>; The School of Medicine, Nankai University, Tianjin, 300071, People's Republic of China.; Department of Orthopaedics, Hebei Medical University Third Hospital, Shijiazhuang, Hebei Province, 050000, People's Republic of China.
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  Data: <searchLink fieldCode="JN" term="%22101475745%22">Drug design, development and therapy</searchLink> [Drug Des Devel Ther] 2025 May 26; Vol. 19, pp. 4383-4396. <i>Date of Electronic Publication: </i>2025 May 26 (<i>Print Publication: </i>2025).
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        Value: 10.2147/DDDT.S516431
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              Text: 2025 May 26
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