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In utero lipid nanoparticle delivery achieves robust editing in hematopoietic stem cells.

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Title: In utero lipid nanoparticle delivery achieves robust editing in hematopoietic stem cells.
Authors: Worthington AK; Department of Surgery, University of California, San Francisco, CA, USA.; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA, USA., Borges B; Department of Surgery, University of California, San Francisco, CA, USA.; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA, USA., Lum T; Department of Surgery, University of California, San Francisco, CA, USA.; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA, USA., Echeverri ES; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, 30332, USA., Zada FM; Department of Surgery, University of California, San Francisco, CA, USA.; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA, USA., Cordero MA; Department of Surgery, University of California, San Francisco, CA, USA.; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA, USA., Kim H; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, 30332, USA., Zenhausern R; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, 30332, USA., Celik O; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, 30332, USA., Shaw C; Intellia Therapeutics, Cambridge, MA., Gutierrez-Martinez P; Intellia Therapeutics, Cambridge, MA., Omarova M; Intellia Therapeutics, Cambridge, MA., Blanchard C; Intellia Therapeutics, Cambridge, MA., Burns S; Intellia Therapeutics, Cambridge, MA., Cromer MK; Department of Surgery, University of California, San Francisco, CA, USA.; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA, USA., Dahlman JE; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, 30332, USA., MacKenzie TC; Department of Surgery, University of California, San Francisco, CA, USA.; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA, USA.; The Center for Maternal-Fetal Precision Medicine, University of California, San Francisco, CA, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 May 12. Date of Electronic Publication: 2025 May 12.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: In utero lipid nanoparticle delivery achieves robust editing in hematopoietic stem cells.
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  Data: <searchLink fieldCode="AU" term="%22Worthington+AK%22">Worthington AK</searchLink>; Department of Surgery, University of California, San Francisco, CA, USA.; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Borges+B%22">Borges B</searchLink>; Department of Surgery, University of California, San Francisco, CA, USA.; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lum+T%22">Lum T</searchLink>; Department of Surgery, University of California, San Francisco, CA, USA.; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Echeverri+ES%22">Echeverri ES</searchLink>; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, 30332, USA.<br /><searchLink fieldCode="AU" term="%22Zada+FM%22">Zada FM</searchLink>; Department of Surgery, University of California, San Francisco, CA, USA.; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Cordero+MA%22">Cordero MA</searchLink>; Department of Surgery, University of California, San Francisco, CA, USA.; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kim+H%22">Kim H</searchLink>; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, 30332, USA.<br /><searchLink fieldCode="AU" term="%22Zenhausern+R%22">Zenhausern R</searchLink>; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, 30332, USA.<br /><searchLink fieldCode="AU" term="%22Celik+O%22">Celik O</searchLink>; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, 30332, USA.<br /><searchLink fieldCode="AU" term="%22Shaw+C%22">Shaw C</searchLink>; Intellia Therapeutics, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Gutierrez-Martinez+P%22">Gutierrez-Martinez P</searchLink>; Intellia Therapeutics, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Omarova+M%22">Omarova M</searchLink>; Intellia Therapeutics, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Blanchard+C%22">Blanchard C</searchLink>; Intellia Therapeutics, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Burns+S%22">Burns S</searchLink>; Intellia Therapeutics, Cambridge, MA.<br /><searchLink fieldCode="AU" term="%22Cromer+MK%22">Cromer MK</searchLink>; Department of Surgery, University of California, San Francisco, CA, USA.; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Dahlman+JE%22">Dahlman JE</searchLink>; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, 30332, USA.<br /><searchLink fieldCode="AU" term="%22MacKenzie+TC%22">MacKenzie TC</searchLink>; Department of Surgery, University of California, San Francisco, CA, USA.; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA, USA.; The Center for Maternal-Fetal Precision Medicine, University of California, San Francisco, CA, USA.
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        Value: 10.1101/2025.05.12.652147
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