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Development of caninized anti-CTLA-4 antibody as salvage combination therapy for anti-PD-L1 refractory tumors in dogs.

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Title: Development of caninized anti-CTLA-4 antibody as salvage combination therapy for anti-PD-L1 refractory tumors in dogs.
Authors: Maekawa N; Department of Advanced Pharmaceutics, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.; Cancer Research Unit, One Health Research Center, Hokkaido University, Sapporo, Japan., Konnai S; Department of Advanced Pharmaceutics, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.; Cancer Research Unit, One Health Research Center, Hokkaido University, Sapporo, Japan.; Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.; Institute for Vaccine Research and Development (HU-IVReD), Hokkaido University, Sapporo, Japan.; Veterinary Research Unit, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan., Watari K; Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan., Takeuchi H; Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.; Institute for Vaccine Research and Development (HU-IVReD), Hokkaido University, Sapporo, Japan., Nakanishi T; Department of Chemistry and Bioengineering, Division of Science and Engineering for Materials, Chemistry and Biology, Graduate School of Engineering, Osaka Metropolitan University, Osaka, Japan., Tachibana T; Department of Chemistry and Bioengineering, Division of Science and Engineering for Materials, Chemistry and Biology, Graduate School of Engineering, Osaka Metropolitan University, Osaka, Japan., Hosoya K; Cancer Research Unit, One Health Research Center, Hokkaido University, Sapporo, Japan.; Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan., Kim S; Cancer Research Unit, One Health Research Center, Hokkaido University, Sapporo, Japan.; Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan., Kinoshita R; Cancer Research Unit, One Health Research Center, Hokkaido University, Sapporo, Japan.; Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan., Owaki R; Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan., Yokokawa M; Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan., Kagawa Y; North Lab, Sapporo, Japan., Takagi S; Department of Veterinary Surgery 1, School of Veterinary Medicine, Azabu University, Sagamihara, Japan., Deguchi T; Companion Animal Internal Medicine, Department of Companion Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan., Ohta H; Companion Animal Internal Medicine, Department of Companion Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan., Kato Y; Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan., Yamamoto S; Department of Advanced Pharmaceutics, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.; Fuso Pharmaceutical Industries, Ltd., Osaka, Japan., Yamamoto K; Department of Advanced Pharmaceutics, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.; Institute for Vaccine Research and Development (HU-IVReD), Hokkaido University, Sapporo, Japan.; Fuso Pharmaceutical Industries, Ltd., Osaka, Japan., Suzuki Y; Department of Advanced Pharmaceutics, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.; Institute for Vaccine Research and Development (HU-IVReD), Hokkaido University, Sapporo, Japan.; Division of Bioresources, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.; Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, Sapporo, Japan., Okagawa T; Department of Advanced Pharmaceutics, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan., Murata S; Department of Advanced Pharmaceutics, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.; Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.; Veterinary Research Unit, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan., Ohashi K; Department of Advanced Pharmaceutics, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.; Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.; Veterinary Research Unit, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.; International Affairs Office, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Source: Frontiers in immunology [Front Immunol] 2025 May 20; Vol. 16, pp. 1570717. Date of Electronic Publication: 2025 May 20 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
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  Data: Development of caninized anti-CTLA-4 antibody as salvage combination therapy for anti-PD-L1 refractory tumors in dogs.
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  Data: <searchLink fieldCode="AU" term="%22Maekawa+N%22">Maekawa N</searchLink>; Department of Advanced Pharmaceutics, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.; Cancer Research Unit, One Health Research Center, Hokkaido University, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Konnai+S%22">Konnai S</searchLink>; Department of Advanced Pharmaceutics, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.; Cancer Research Unit, One Health Research Center, Hokkaido University, Sapporo, Japan.; Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.; Institute for Vaccine Research and Development (HU-IVReD), Hokkaido University, Sapporo, Japan.; Veterinary Research Unit, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Watari+K%22">Watari K</searchLink>; Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Takeuchi+H%22">Takeuchi H</searchLink>; Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.; Institute for Vaccine Research and Development (HU-IVReD), Hokkaido University, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Nakanishi+T%22">Nakanishi T</searchLink>; Department of Chemistry and Bioengineering, Division of Science and Engineering for Materials, Chemistry and Biology, Graduate School of Engineering, Osaka Metropolitan University, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Tachibana+T%22">Tachibana T</searchLink>; Department of Chemistry and Bioengineering, Division of Science and Engineering for Materials, Chemistry and Biology, Graduate School of Engineering, Osaka Metropolitan University, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Hosoya+K%22">Hosoya K</searchLink>; Cancer Research Unit, One Health Research Center, Hokkaido University, Sapporo, Japan.; Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Kim+S%22">Kim S</searchLink>; Cancer Research Unit, One Health Research Center, Hokkaido University, Sapporo, Japan.; Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Kinoshita+R%22">Kinoshita R</searchLink>; Cancer Research Unit, One Health Research Center, Hokkaido University, Sapporo, Japan.; Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Owaki+R%22">Owaki R</searchLink>; Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Yokokawa+M%22">Yokokawa M</searchLink>; Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Kagawa+Y%22">Kagawa Y</searchLink>; North Lab, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Takagi+S%22">Takagi S</searchLink>; Department of Veterinary Surgery 1, School of Veterinary Medicine, Azabu University, Sagamihara, Japan.<br /><searchLink fieldCode="AU" term="%22Deguchi+T%22">Deguchi T</searchLink>; Companion Animal Internal Medicine, Department of Companion Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan.<br /><searchLink fieldCode="AU" term="%22Ohta+H%22">Ohta H</searchLink>; Companion Animal Internal Medicine, Department of Companion Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Japan.<br /><searchLink fieldCode="AU" term="%22Kato+Y%22">Kato Y</searchLink>; Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Yamamoto+S%22">Yamamoto S</searchLink>; Department of Advanced Pharmaceutics, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.; Fuso Pharmaceutical Industries, Ltd., Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Yamamoto+K%22">Yamamoto K</searchLink>; Department of Advanced Pharmaceutics, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.; Institute for Vaccine Research and Development (HU-IVReD), Hokkaido University, Sapporo, Japan.; Fuso Pharmaceutical Industries, Ltd., Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Suzuki+Y%22">Suzuki Y</searchLink>; Department of Advanced Pharmaceutics, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.; Institute for Vaccine Research and Development (HU-IVReD), Hokkaido University, Sapporo, Japan.; Division of Bioresources, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.; Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Okagawa+T%22">Okagawa T</searchLink>; Department of Advanced Pharmaceutics, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Murata+S%22">Murata S</searchLink>; Department of Advanced Pharmaceutics, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.; Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.; Veterinary Research Unit, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Ohashi+K%22">Ohashi K</searchLink>; Department of Advanced Pharmaceutics, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.; Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.; Veterinary Research Unit, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan.; International Affairs Office, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
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  Data: <searchLink fieldCode="JN" term="%22101560960%22">Frontiers in immunology</searchLink> [Front Immunol] 2025 May 20; Vol. 16, pp. 1570717. <i>Date of Electronic Publication: </i>2025 May 20 (<i>Print Publication: </i>2025).
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