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Dose-individualisation of fluoropyrimidines based on pre-treatment serum uracil levels: the Alpe2U study.

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Title: Dose-individualisation of fluoropyrimidines based on pre-treatment serum uracil levels: the Alpe2U study.
Authors: Knikman JE; Div. of Pharmacology, The Netherlands Cancer Institute, Amsterdam, the Netherlands; Dept. of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, the Netherlands., de With M; Dept. of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Centre, Rotterdam, the Netherlands; Dept. of Clinical Chemistry, Erasmus University Medical Centre, Rotterdam, the Netherlands., Heersche N; Dept. of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Centre, Rotterdam, the Netherlands; Dept. of Clinical Chemistry, Erasmus University Medical Centre, Rotterdam, the Netherlands., Lopez-Yurda M; Biometrics Dept., The Netherlands Cancer Institute, Amsterdam, the Netherlands., Baars A; Dept. of Medical Oncology, Hospital Gelderse Vallei, Ede, the Netherlands., Creemers GJ; Dept. of Medical Oncology, Catharina Hospital, Eindhoven, the Netherlands., Droogendijk HJ; Dept. of Internal Medicine, Bravis Hospital, Roosendaal, the Netherlands., Fiets E; Dept. of Internal Medicine, Medical Centre Leeuwarden, Leeuwarden, the Netherlands., Imholz ALT; Dept. of Internal Medicine, Deventer Hospital, Deventer, the Netherlands., Iersel LV; Dept. of Internal Medicine, Division of Medical Oncology, GROW-School for Oncology and Developmental Biology, Maastricht UMC+, Maastricht, the Netherlands., Mandigers CMPW; Dept. of Internal Medicine, Canisius-Wilhelmina Hospital, Nijmegen, the Netherlands., van de Vendel AJ; Dept. of Medical Oncology, Hospital Gelderse Vallei, Ede, the Netherlands., Jeurissen FJF; Dept. of Internal Medicine, Haaglanden Medical Centre, The Hague, the Netherlands., Nieboer P; Dept. of Internal Medicine, Wilhelmina Hospital Assen, Assen, the Netherlands., Deenen MJ; Dept. of Clinical Pharmacy, Catharina Hospital, Eindhoven, the Netherlands; Dept. of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, the Netherlands., van de Poel MHW; Dept. of Internal Medicine, Laurentius Hospital, Roermond, the Netherlands., Wymenga MNM; Dept. of Internal Medicine, Medisch Spectrum Twente, Enschede, the Netherlands., van Schaik RHN; Dept. of Clinical Chemistry, Erasmus University Medical Centre, Rotterdam, the Netherlands., van den Bosch BJC; Dept. Of Clinical Genetics, Maastricht University Medical Centre, Maastricht, the Netherlands., Hoop EO; Dept. of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Centre, Rotterdam, the Netherlands., Rosing H; Dept. of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, the Netherlands., Swen JJ; Dept. of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, the Netherlands., Gelderblom H; Dept. of Medical Oncology, Leiden University Medical Centre, Leiden, the Netherlands., Schellens JHM; Dept. of Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands., Beijnen JH; Dept. of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, the Netherlands; Div. of Pharmacoepidemiology and Clinical Pharmacology, Dept. of Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands., Mathijssen RHJ; Dept. of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Centre, Rotterdam, the Netherlands., Guchelaar HJ; Dept. of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, the Netherlands., Cats A; Dept. of Gastrointestinal Oncology, Div. of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands. Electronic address: a.cats@nki.nl.
Source: European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2025 Jun 25; Vol. 224, pp. 115483. Date of Electronic Publication: 2025 Apr 30.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9005373 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0852 (Electronic) Linking ISSN: 09598049 NLM ISO Abbreviation: Eur J Cancer Subsets: MEDLINE
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  Data: Dose-individualisation of fluoropyrimidines based on pre-treatment serum uracil levels: the Alpe2U study.
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  Data: <searchLink fieldCode="AU" term="%22Knikman+JE%22">Knikman JE</searchLink>; Div. of Pharmacology, The Netherlands Cancer Institute, Amsterdam, the Netherlands; Dept. of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22de+With+M%22">de With M</searchLink>; Dept. of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Centre, Rotterdam, the Netherlands; Dept. of Clinical Chemistry, Erasmus University Medical Centre, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Heersche+N%22">Heersche N</searchLink>; Dept. of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Centre, Rotterdam, the Netherlands; Dept. of Clinical Chemistry, Erasmus University Medical Centre, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Lopez-Yurda+M%22">Lopez-Yurda M</searchLink>; Biometrics Dept., The Netherlands Cancer Institute, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Baars+A%22">Baars A</searchLink>; Dept. of Medical Oncology, Hospital Gelderse Vallei, Ede, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Creemers+GJ%22">Creemers GJ</searchLink>; Dept. of Medical Oncology, Catharina Hospital, Eindhoven, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Droogendijk+HJ%22">Droogendijk HJ</searchLink>; Dept. of Internal Medicine, Bravis Hospital, Roosendaal, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Fiets+E%22">Fiets E</searchLink>; Dept. of Internal Medicine, Medical Centre Leeuwarden, Leeuwarden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Imholz+ALT%22">Imholz ALT</searchLink>; Dept. of Internal Medicine, Deventer Hospital, Deventer, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Iersel+LV%22">Iersel LV</searchLink>; Dept. of Internal Medicine, Division of Medical Oncology, GROW-School for Oncology and Developmental Biology, Maastricht UMC+, Maastricht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Mandigers+CMPW%22">Mandigers CMPW</searchLink>; Dept. of Internal Medicine, Canisius-Wilhelmina Hospital, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+de+Vendel+AJ%22">van de Vendel AJ</searchLink>; Dept. of Medical Oncology, Hospital Gelderse Vallei, Ede, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Jeurissen+FJF%22">Jeurissen FJF</searchLink>; Dept. of Internal Medicine, Haaglanden Medical Centre, The Hague, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Nieboer+P%22">Nieboer P</searchLink>; Dept. of Internal Medicine, Wilhelmina Hospital Assen, Assen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Deenen+MJ%22">Deenen MJ</searchLink>; Dept. of Clinical Pharmacy, Catharina Hospital, Eindhoven, the Netherlands; Dept. of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+de+Poel+MHW%22">van de Poel MHW</searchLink>; Dept. of Internal Medicine, Laurentius Hospital, Roermond, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Wymenga+MNM%22">Wymenga MNM</searchLink>; Dept. of Internal Medicine, Medisch Spectrum Twente, Enschede, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Schaik+RHN%22">van Schaik RHN</searchLink>; Dept. of Clinical Chemistry, Erasmus University Medical Centre, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+den+Bosch+BJC%22">van den Bosch BJC</searchLink>; Dept. Of Clinical Genetics, Maastricht University Medical Centre, Maastricht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Hoop+EO%22">Hoop EO</searchLink>; Dept. of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Centre, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Rosing+H%22">Rosing H</searchLink>; Dept. of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Swen+JJ%22">Swen JJ</searchLink>; Dept. of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Gelderblom+H%22">Gelderblom H</searchLink>; Dept. of Medical Oncology, Leiden University Medical Centre, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Schellens+JHM%22">Schellens JHM</searchLink>; Dept. of Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Beijnen+JH%22">Beijnen JH</searchLink>; Dept. of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, the Netherlands; Div. of Pharmacoepidemiology and Clinical Pharmacology, Dept. of Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Mathijssen+RHJ%22">Mathijssen RHJ</searchLink>; Dept. of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Centre, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Guchelaar+HJ%22">Guchelaar HJ</searchLink>; Dept. of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Cats+A%22">Cats A</searchLink>; Dept. of Gastrointestinal Oncology, Div. of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands. Electronic address: a.cats@nki.nl.
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  Data: <searchLink fieldCode="JN" term="%229005373%22">European journal of cancer (Oxford, England : 1990)</searchLink> [Eur J Cancer] 2025 Jun 25; Vol. 224, pp. 115483. <i>Date of Electronic Publication: </i>2025 Apr 30.
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