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Polygenic scores for obstructive sleep apnoea reveal pathways contributing to cardiovascular disease.

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Title: Polygenic scores for obstructive sleep apnoea reveal pathways contributing to cardiovascular disease.
Authors: Kurniansyah N; VA Boston Healthcare System, Boston, MA, USA; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Department of Bioinformatics, Boston University, Boston, MA, USA., Strausz SJ; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA; Department of Oral and Maxillofacial Diseases, Helsinki University Hospital, Helsinki, Finland; Department of Cleft Palate and Craniofacial Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Orthodontics, Department of Oral and Maxillofacial Diseases, Clinicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Chittoor G; Department of Population Health Sciences, Geisinger Health System, Danville, PA, USA., Gupta S; Department of Population Health Sciences, Geisinger Health System, Danville, PA, USA., Justice AE; Department of Population Health Sciences, Geisinger Health System, Danville, PA, USA., Hrytsenko Y; Department of Medicine, Harvard Medical School, Boston, MA, USA; CardioVascular Institute (CVI), Beth Israel Deaconess Medical Center, Boston, MA, USA., Keenan BT; Division of Sleep Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Cade BE; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA., Spitzer BW; CardioVascular Institute (CVI), Beth Israel Deaconess Medical Center, Boston, MA, USA., Wang H; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA., Huffman J; Department of Medicine, Harvard Medical School, Boston, MA, USA; Massachusetts Veterans Epidemiology Research and Information Center, Veterans Affairs Boston Healthcare System, Boston, MA, USA; VA Palo Alto Health Care System, Palo Alto, CA, USA; Palo Alto Veterans Institute for Research, Palo Alto, CA, USA., Moll MR; Department of Medicine, Harvard Medical School, Boston, MA, USA; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA; Section on Pulmonary, Critical Care, Sleep, and Allergy, Veterans Affairs Boston Healthcare System, West Roxbury, MA, USA., Haring B; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Medicine III, Saarland University, Homburg, Germany., Jung SY; Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA, USA; Translational Sciences Section, School of Nursing, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA, USA., Raffield LM; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Kaplan R; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Rich SS; Department of Genome Sciences, University of Virginia School of Medicine, Charlottesville, VA, USA., Gharib SA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA; Division of Pulmonary, Critical Care and Sleep Medicine, Computational Medicine Core, Center for Lung Biology, University of Washington, Seattle, WA, USA., Bartz TM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA; Department of Biostatistics, University of Washington, Seattle, WA, USA., Liu PY; Division of Genetics, Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Chen H; Human Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Fornage M; Human Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Hou L; Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Levy D; The Population Sciences Branch of the National Heart, Lung and Blood Institute, Bethesda, MD, USA; The Framingham Heart Study, Framingham, MA, USA., Morrison AC; Human Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Ochs-Balcom HM; Department of Epidemiology and Environmental Health, University of Buffalo, Buffalo, NY, USA., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA; Department of Medicine, University of Washington, Seattle, WA, USA; Health Systems and Population Health, University of Washington, Seattle, WA, USA., Wilson PWF; Atlanta VA Healthcare System, Decatur, GA, USA; Emory Clinical Cardiovascular Research Institute, Atlanta, GA, USA., Cho K; VA Boston Healthcare System, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA; Division of Aging, Brigham and Women's Hospital, Department of Medicine, Boston, MA, USA., Pack AI; Circadian Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Sleep Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Ollila HM; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Redline S; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA., Gottlieb DJ; VA Boston Healthcare System, Boston, MA, USA; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA., Sofer T; VA Boston Healthcare System, Boston, MA, USA; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA; Division of Sleep Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address: tsofer@bidmc.harvard.edu.
Corporate Authors: FinnGen, Trans-Omics in Precision Medicine Consortium, VA Million Veteran Program
Source: EBioMedicine [EBioMedicine] 2025 Jul; Vol. 117, pp. 105790. Date of Electronic Publication: 2025 Jun 04.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101647039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3964 (Electronic) Linking ISSN: 23523964 NLM ISO Abbreviation: EBioMedicine Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Kurniansyah+N%22">Kurniansyah N</searchLink>; VA Boston Healthcare System, Boston, MA, USA; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Department of Bioinformatics, Boston University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Strausz+SJ%22">Strausz SJ</searchLink>; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA; Department of Oral and Maxillofacial Diseases, Helsinki University Hospital, Helsinki, Finland; Department of Cleft Palate and Craniofacial Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Orthodontics, Department of Oral and Maxillofacial Diseases, Clinicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Chittoor+G%22">Chittoor G</searchLink>; 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