Identification and heterologous expression of an NRPS biosynthetic gene cluster responsible for the production of the pyrazinones Ichizinone A, B and C.

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Title: Identification and heterologous expression of an NRPS biosynthetic gene cluster responsible for the production of the pyrazinones Ichizinone A, B and C.
Authors: Oberhäuser P; Department of Pharmaceutical Biotechnology, Saarland University, 66123, Saarbrücken, Germany.; INM- Leibniz Institute for New Materials, Campus D2 2, 66123, Saarbrücken, Germany., Myronovskyi M; Department of Pharmaceutical Biotechnology, Saarland University, 66123, Saarbrücken, Germany., Stierhof M; Department of Pharmaceutical Biotechnology, Saarland University, 66123, Saarbrücken, Germany., Gromyko O; Department of Genetics and Biotechnology, Ivan Franko National University of Lviv, Lviv, 79005, Ukraine.; Microbial Culture Collection of Antibiotic Producers, Ivan Franko National University of Lviv, Lviv, 79005, Ukraine., Luzhetskyy A; Department of Pharmaceutical Biotechnology, Saarland University, 66123, Saarbrücken, Germany. a.luzhetskyy@mx.uni-saarland.de.; Helmholtz Institute for Pharmaceutical Research Saarland, 66123, Saarbrücken, Germany. a.luzhetskyy@mx.uni-saarland.de.
Source: Microbial cell factories [Microb Cell Fact] 2025 Jun 07; Vol. 24 (1), pp. 131. Date of Electronic Publication: 2025 Jun 07.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101139812 Publication Model: Electronic Cited Medium: Internet ISSN: 1475-2859 (Electronic) Linking ISSN: 14752859 NLM ISO Abbreviation: Microb Cell Fact Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1475-2859
DOI:10.1186/s12934-025-02753-6