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The specificity and structure of DNA crosslinking by the gut bacterial genotoxin colibactin.

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Title: The specificity and structure of DNA crosslinking by the gut bacterial genotoxin colibactin.
Authors: Carlson ES; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA., Haslecker R; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA., Lecchi C; Masonic Cancer Center University of Minnesota, Minneapolis, MN 55455, USA., Aguilar Ramos MA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA., Vennelakanti V; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Honaker L; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA., Stornetta A; Masonic Cancer Center University of Minnesota, Minneapolis, MN 55455, USA., Millán ES; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA., Johnson BA; Structural Biology Initiative, City University of New York (CUNY) Advanced Science Research Center, New York, NY 10031, USA., Kulik HJ; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Balbo S; Masonic Cancer Center University of Minnesota, Minneapolis, MN 55455, USA., Villalta PW; Masonic Cancer Center University of Minnesota, Minneapolis, MN 55455, USA.; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA., D'Souza V; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA., Balskus EP; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Oct 01. Date of Electronic Publication: 2025 Oct 01.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Carlson+ES%22">Carlson ES</searchLink>; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.<br /><searchLink fieldCode="AU" term="%22Haslecker+R%22">Haslecker R</searchLink>; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.<br /><searchLink fieldCode="AU" term="%22Lecchi+C%22">Lecchi C</searchLink>; Masonic Cancer Center University of Minnesota, Minneapolis, MN 55455, USA.<br /><searchLink fieldCode="AU" term="%22Aguilar+Ramos+MA%22">Aguilar Ramos MA</searchLink>; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.<br /><searchLink fieldCode="AU" term="%22Vennelakanti+V%22">Vennelakanti V</searchLink>; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Honaker+L%22">Honaker L</searchLink>; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.<br /><searchLink fieldCode="AU" term="%22Stornetta+A%22">Stornetta A</searchLink>; Masonic Cancer Center University of Minnesota, Minneapolis, MN 55455, USA.<br /><searchLink fieldCode="AU" term="%22Millán+ES%22">Millán ES</searchLink>; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+BA%22">Johnson BA</searchLink>; Structural Biology Initiative, City University of New York (CUNY) Advanced Science Research Center, New York, NY 10031, USA.<br /><searchLink fieldCode="AU" term="%22Kulik+HJ%22">Kulik HJ</searchLink>; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Balbo+S%22">Balbo S</searchLink>; Masonic Cancer Center University of Minnesota, Minneapolis, MN 55455, USA.<br /><searchLink fieldCode="AU" term="%22Villalta+PW%22">Villalta PW</searchLink>; Masonic Cancer Center University of Minnesota, Minneapolis, MN 55455, USA.; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.<br /><searchLink fieldCode="AU" term="%22D'Souza+V%22">D'Souza V</searchLink>; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.<br /><searchLink fieldCode="AU" term="%22Balskus+EP%22">Balskus EP</searchLink>; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
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