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Multiplex and multimodal mapping of variant effects in secreted proteins via MultiSTEP.

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Title: Multiplex and multimodal mapping of variant effects in secreted proteins via MultiSTEP.
Authors: Popp NA; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.; Medical Scientist Training Program, University of Washington School of Medicine, Seattle, WA, USA.; Brotman Baty Institute for Precision Medicine, Seattle, WA, USA., Powell RL; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA., Wheelock MK; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.; Brotman Baty Institute for Precision Medicine, Seattle, WA, USA., Holmes KJ; Division of Hematology and Oncology, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA.; Center for Cardiovascular Biology, University of Washington School of Medicine, Seattle, WA, USA.; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA., Zapp BD; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA., Sheldon KM; Division of Hematology and Oncology, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA.; Center for Cardiovascular Biology, University of Washington School of Medicine, Seattle, WA, USA.; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA., Fletcher SN; Bloodworks Northwest, Seattle, WA, USA., Wu X; Bloodworks Northwest, Seattle, WA, USA.; Cell Marker Laboratory, Seattle Children's Hospital, Seattle, WA, USA., Fayer S; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.; Brotman Baty Institute for Precision Medicine, Seattle, WA, USA., Rubin AF; Bioinformatics Division, WEHI, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia., Lannert KW; Division of Hematology and Oncology, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA.; Center for Cardiovascular Biology, University of Washington School of Medicine, Seattle, WA, USA.; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA., Chang AT; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA., Sheehan JP; Division of Hematology, Medical Oncology, and Palliative Care, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; University of Wisconsin Comprehensive Bleeding Disorders Program, Madison, WI, USA., Johnsen JM; Division of Hematology and Oncology, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA. jjohnsen@uw.edu.; Center for Cardiovascular Biology, University of Washington School of Medicine, Seattle, WA, USA. jjohnsen@uw.edu.; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA. jjohnsen@uw.edu.; Bloodworks Northwest, Seattle, WA, USA. jjohnsen@uw.edu.; Washington Center for Bleeding Disorders, Seattle, WA, USA. jjohnsen@uw.edu., Fowler DM; Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA. dfowler@uw.edu.; Brotman Baty Institute for Precision Medicine, Seattle, WA, USA. dfowler@uw.edu.; Department of Bioengineering, University of Washington School of Medicine, Seattle, WA, USA. dfowler@uw.edu.
Source: Nature structural & molecular biology [Nat Struct Mol Biol] 2025 Oct; Vol. 32 (10), pp. 2099-2111. Date of Electronic Publication: 2025 Jun 13.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE
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