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Zabedosertib, a novel interleukin-1 receptor-associated kinase-4 inhibitor, shows a favorable pharmacokinetic and safety profile across multiple phase 1 studies.

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Title: Zabedosertib, a novel interleukin-1 receptor-associated kinase-4 inhibitor, shows a favorable pharmacokinetic and safety profile across multiple phase 1 studies.
Authors: Feldmüller M; Clinical Pharmacology, Research and Development, Pharmaceuticals, Bayer AG, Berlin, Germany., Jodl SJ; Translational Medicine, Research and Development, Pharmaceuticals, Bayer AG, Berlin, Germany., Ploeger B; Model-Informed Drug Development, Research and Development, Pharmaceuticals, Bayer AG, Berlin, Germany., Wagenfeld A; Translational Science, Pharmaceuticals, Bayer AG, Berlin, Germany., Wiesinger H; Clinical Pharmacology, Research and Development, Pharmaceuticals, Bayer AG, Berlin, Germany., Zollmann FS; Pharma Consult, Berlin, Germany., Klein S; Research and Early Development Statistics, Research and Development, Pharmaceuticals, Bayer AG, Berlin, Germany., Zhang R; Medical Affairs China, Pharmaceuticals, Bayer Healthcare Co., Ltd., Beijing, China., Rohde B; Translational Medicine, Research and Development, Pharmaceuticals, Bayer AG, Berlin, Germany., Höchel J; Early Clinical Development, Research and Development, Pharmaceuticals, Bayer AG, Berlin, Germany.
Source: Frontiers in pharmacology [Front Pharmacol] 2025 May 30; Vol. 16, pp. 1521505. Date of Electronic Publication: 2025 May 30 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Zabedosertib, a novel interleukin-1 receptor-associated kinase-4 inhibitor, shows a favorable pharmacokinetic and safety profile across multiple phase 1 studies.
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  Data: <searchLink fieldCode="AU" term="%22Feldmüller+M%22">Feldmüller M</searchLink>; Clinical Pharmacology, Research and Development, Pharmaceuticals, Bayer AG, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Jodl+SJ%22">Jodl SJ</searchLink>; Translational Medicine, Research and Development, Pharmaceuticals, Bayer AG, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Ploeger+B%22">Ploeger B</searchLink>; Model-Informed Drug Development, Research and Development, Pharmaceuticals, Bayer AG, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Wagenfeld+A%22">Wagenfeld A</searchLink>; Translational Science, Pharmaceuticals, Bayer AG, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Wiesinger+H%22">Wiesinger H</searchLink>; Clinical Pharmacology, Research and Development, Pharmaceuticals, Bayer AG, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Zollmann+FS%22">Zollmann FS</searchLink>; Pharma Consult, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Klein+S%22">Klein S</searchLink>; Research and Early Development Statistics, Research and Development, Pharmaceuticals, Bayer AG, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Zhang+R%22">Zhang R</searchLink>; Medical Affairs China, Pharmaceuticals, Bayer Healthcare Co., Ltd., Beijing, China.<br /><searchLink fieldCode="AU" term="%22Rohde+B%22">Rohde B</searchLink>; Translational Medicine, Research and Development, Pharmaceuticals, Bayer AG, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Höchel+J%22">Höchel J</searchLink>; Early Clinical Development, Research and Development, Pharmaceuticals, Bayer AG, Berlin, Germany.
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              Text: 2025 May 30
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