Garsorasib, a KRAS G12C inhibitor, with or without cetuximab, an EGFR antibody, in colorectal cancer cohorts of a phase II trial in advanced solid tumors with KRAS G12C mutation.
Saved in:
| Title: | Garsorasib, a KRAS G12C inhibitor, with or without cetuximab, an EGFR antibody, in colorectal cancer cohorts of a phase II trial in advanced solid tumors with KRAS G12C mutation. |
|---|---|
| Authors: | Ruan DY; Department of Clinical Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University, Guangzhou, China.; Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer, Chinese Academy of Medical Sciences, Guangzhou, China., Wu HX; Department of Clinical Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University, Guangzhou, China.; Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer, Chinese Academy of Medical Sciences, Guangzhou, China., Xu Y; Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, China., Munster PN; Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Deng Y; Department of Medical Oncology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China., Richardson G; Department of Medical Oncology, Cabrini Hospital - Malvern, Malvern, VIC, Australia., Yan D; Department of Oncology, Beijing Luhe Hospital Affiliated to Capital Medical University, Beijing, China., Lee MA; Division of Medical Oncology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, Cancer Research Institute, The Catholic University of Korea, Seoul, South Korea., Lee KW; Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea., Pan H; Department of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China., Hager S; Medical Oncology Hematology, California Cancer Associates for Research and Excellence, Inc. (cCARE), Fresno, CA, USA., Li X; Department of Medical Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Wei S; Department of Gastrointestinal Oncology Surgery, Hubei Cancer Hospital, Wuhan, China., Hou X; Department of Medical Oncology, Henan Cancer Hospital, Zhengzhou, China., Underhill C; Border Medical Oncology Research Unit, Albury Wodonga Regional Cancer Centre, Albury, NSW, Australia., Millward M; Linear Clinical Research & University of Western Australia, Perth, WA, Australia., Nordman I; Medical Oncology Department, Calvary Mater Newcastle, Waratah, NSW, Australia., Zhang J; Medical Oncology Department of Gastrointestinal Cancer, Liaoning Cancer Hospital & Institute, Shenyang, China., Shan J; Department of Medical Oncology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China., Han G; Department of Liver Diseases and Digestive Interventional Radiology, Xi'an International Medical Center Hospital, Xi'an, China., Grewal J; Medical Oncology Hematology, Norton Cancer Institute, Louisville, KY, USA., Gadgeel SM; Division of Hematology and Oncology, Department of Internal Medicine, Henry Ford Cancer Institute/Henry Ford Health System, Detroit, MI, USA., Sanborn RE; Medical Oncology Department, Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA., Huh SJ; Division of Hematology-Oncology, Department of Internal Medicine, Dong-A University College of Medicine, Busan, South Korea., Hu X; Department of Medical Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China., Zhang Y; InventisBio Co. Ltd, Shanghai, China., Xiang Z; InventisBio Co. Ltd, Shanghai, China., Luo L; InventisBio Co. Ltd, Shanghai, China., Xie X; InventisBio Co. Ltd, Shanghai, China., Shi Z; InventisBio Co. Ltd, Shanghai, China., Wang Y; InventisBio Co. Ltd, Shanghai, China., Zhang L; InventisBio Co. Ltd, Shanghai, China., Wang F; Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer, Chinese Academy of Medical Sciences, Guangzhou, China. wangfeng@sysucc.org.cn.; Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University, Guangzhou, China. wangfeng@sysucc.org.cn., Xu RH; Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer, Chinese Academy of Medical Sciences, Guangzhou, China. xurh@sysucc.org.cn.; Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University, Guangzhou, China. xurh@sysucc.org.cn. |
| Source: | Signal transduction and targeted therapy [Signal Transduct Target Ther] 2025 Jun 17; Vol. 10 (1), pp. 189. Date of Electronic Publication: 2025 Jun 17. |
| Publication Type: | Journal Article; Clinical Trial, Phase II |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
|
Full text is not displayed to guests.
Login for full access.
|
|
| FullText | Links: – Type: pdflink Text: Availability: 1 |
|---|---|
| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40523897 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Garsorasib, a KRAS G12C inhibitor, with or without cetuximab, an EGFR antibody, in colorectal cancer cohorts of a phase II trial in advanced solid tumors with KRAS G12C mutation. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Ruan+DY%22">Ruan DY</searchLink>; Department of Clinical Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University, Guangzhou, China.; Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer, Chinese Academy of Medical Sciences, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Wu+HX%22">Wu HX</searchLink>; Department of Clinical Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University, Guangzhou, China.; Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer, Chinese Academy of Medical Sciences, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Xu+Y%22">Xu Y</searchLink>; Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Munster+PN%22">Munster PN</searchLink>; Department of Medicine, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Deng+Y%22">Deng Y</searchLink>; Department of Medical Oncology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Richardson+G%22">Richardson G</searchLink>; Department of Medical Oncology, Cabrini Hospital - Malvern, Malvern, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Yan+D%22">Yan D</searchLink>; Department of Oncology, Beijing Luhe Hospital Affiliated to Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Lee+MA%22">Lee MA</searchLink>; Division of Medical Oncology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, Cancer Research Institute, The Catholic University of Korea, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Lee+KW%22">Lee KW</searchLink>; Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Pan+H%22">Pan H</searchLink>; Department of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Hager+S%22">Hager S</searchLink>; Medical Oncology Hematology, California Cancer Associates for Research and Excellence, Inc. (cCARE), Fresno, CA, USA.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Department of Medical Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Wei+S%22">Wei S</searchLink>; Department of Gastrointestinal Oncology Surgery, Hubei Cancer Hospital, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Hou+X%22">Hou X</searchLink>; Department of Medical Oncology, Henan Cancer Hospital, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Underhill+C%22">Underhill C</searchLink>; Border Medical Oncology Research Unit, Albury Wodonga Regional Cancer Centre, Albury, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Millward+M%22">Millward M</searchLink>; Linear Clinical Research & University of Western Australia, Perth, WA, Australia.<br /><searchLink fieldCode="AU" term="%22Nordman+I%22">Nordman I</searchLink>; Medical Oncology Department, Calvary Mater Newcastle, Waratah, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Medical Oncology Department of Gastrointestinal Cancer, Liaoning Cancer Hospital & Institute, Shenyang, China.<br /><searchLink fieldCode="AU" term="%22Shan+J%22">Shan J</searchLink>; Department of Medical Oncology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Han+G%22">Han G</searchLink>; Department of Liver Diseases and Digestive Interventional Radiology, Xi'an International Medical Center Hospital, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Grewal+J%22">Grewal J</searchLink>; Medical Oncology Hematology, Norton Cancer Institute, Louisville, KY, USA.<br /><searchLink fieldCode="AU" term="%22Gadgeel+SM%22">Gadgeel SM</searchLink>; Division of Hematology and Oncology, Department of Internal Medicine, Henry Ford Cancer Institute/Henry Ford Health System, Detroit, MI, USA.<br /><searchLink fieldCode="AU" term="%22Sanborn+RE%22">Sanborn RE</searchLink>; Medical Oncology Department, Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Huh+SJ%22">Huh SJ</searchLink>; Division of Hematology-Oncology, Department of Internal Medicine, Dong-A University College of Medicine, Busan, South Korea.<br /><searchLink fieldCode="AU" term="%22Hu+X%22">Hu X</searchLink>; Department of Medical Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; InventisBio Co. Ltd, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Xiang+Z%22">Xiang Z</searchLink>; InventisBio Co. Ltd, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Luo+L%22">Luo L</searchLink>; InventisBio Co. Ltd, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Xie+X%22">Xie X</searchLink>; InventisBio Co. Ltd, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Shi+Z%22">Shi Z</searchLink>; InventisBio Co. Ltd, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; InventisBio Co. Ltd, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; InventisBio Co. Ltd, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wang+F%22">Wang F</searchLink>; Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer, Chinese Academy of Medical Sciences, Guangzhou, China. wangfeng@sysucc.org.cn.; Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University, Guangzhou, China. wangfeng@sysucc.org.cn.<br /><searchLink fieldCode="AU" term="%22Xu+RH%22">Xu RH</searchLink>; Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer, Chinese Academy of Medical Sciences, Guangzhou, China. xurh@sysucc.org.cn.; Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University, Guangzhou, China. xurh@sysucc.org.cn. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101676423%22">Signal transduction and targeted therapy</searchLink> [Signal Transduct Target Ther] 2025 Jun 17; Vol. 10 (1), pp. 189. <i>Date of Electronic Publication: </i>2025 Jun 17. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Clinical Trial, Phase II – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101676423 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2059-3635 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220593635%22">20593635 </searchLink><i>NLM ISO Abbreviation: </i>Signal Transduct Target Ther <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40523897 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41392-025-02274-z Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 189 Titles: – TitleFull: Garsorasib, a KRAS G12C inhibitor, with or without cetuximab, an EGFR antibody, in colorectal cancer cohorts of a phase II trial in advanced solid tumors with KRAS G12C mutation. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ruan DY – PersonEntity: Name: NameFull: Wu HX – PersonEntity: Name: NameFull: Xu Y – PersonEntity: Name: NameFull: Munster PN – PersonEntity: Name: NameFull: Deng Y – PersonEntity: Name: NameFull: Richardson G – PersonEntity: Name: NameFull: Yan D – PersonEntity: Name: NameFull: Lee MA – PersonEntity: Name: NameFull: Lee KW – PersonEntity: Name: NameFull: Pan H – PersonEntity: Name: NameFull: Hager S – PersonEntity: Name: NameFull: Li X – PersonEntity: Name: NameFull: Wei S – PersonEntity: Name: NameFull: Hou X – PersonEntity: Name: NameFull: Underhill C – PersonEntity: Name: NameFull: Millward M – PersonEntity: Name: NameFull: Nordman I – PersonEntity: Name: NameFull: Zhang J – PersonEntity: Name: NameFull: Shan J – PersonEntity: Name: NameFull: Han G – PersonEntity: Name: NameFull: Grewal J – PersonEntity: Name: NameFull: Gadgeel SM – PersonEntity: Name: NameFull: Sanborn RE – PersonEntity: Name: NameFull: Huh SJ – PersonEntity: Name: NameFull: Hu X – PersonEntity: Name: NameFull: Zhang Y – PersonEntity: Name: NameFull: Xiang Z – PersonEntity: Name: NameFull: Luo L – PersonEntity: Name: NameFull: Xie X – PersonEntity: Name: NameFull: Shi Z – PersonEntity: Name: NameFull: Wang Y – PersonEntity: Name: NameFull: Zhang L – PersonEntity: Name: NameFull: Wang F – PersonEntity: Name: NameFull: Xu RH IsPartOfRelationships: – BibEntity: Dates: – D: 17 M: 06 Text: 2025 Jun 17 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 2059-3635 Numbering: – Type: volume Value: 10 – Type: issue Value: 1 Titles: – TitleFull: Signal transduction and targeted therapy Type: main |
| ResultId | 1 |
