Epac1 increases myosin regulatory light-chain phosphorylation, energetic cost of contraction, and susceptibility to heart failure.

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Title: Epac1 increases myosin regulatory light-chain phosphorylation, energetic cost of contraction, and susceptibility to heart failure.
Authors: Ohnuki Y; Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan.; Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Suita K; Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan.; Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Ishikawa M; Department of Oral Anatomy, Tsurumi University School of Dental Medicine, Yokohama, Japan., Mototani Y; Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan., Nariyama M; Department of Pediatric Dentistry, Tsurumi University School of Dental Medicine, Yokohama, Japan., Ito A; Department of Orthodontics, Tsurumi University School of Dental Medicine, Yokohama, Japan., Matsuo I; Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan.; Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Japan.; Department of Periodontology, Tsurumi University School of Dental Medicine, Yokohama, Japan., Hayakawa Y; Department of Dental Anesthesiology, Tsurumi University School of Dental Medicine, Yokohama, Japan., Morii A; Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan.; Department of Periodontology, Tsurumi University School of Dental Medicine, Yokohama, Japan., Mitsubayashi T; Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan., Saeki Y; Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan., Ishikawa Y; Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Okumura S; Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan.; Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Source: PloS one [PLoS One] 2025 Jun 17; Vol. 20 (6), pp. e0325986. Date of Electronic Publication: 2025 Jun 17 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
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  Data: Epac1 increases myosin regulatory light-chain phosphorylation, energetic cost of contraction, and susceptibility to heart failure.
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  Data: <searchLink fieldCode="AU" term="%22Ohnuki+Y%22">Ohnuki Y</searchLink>; Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan.; Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Suita+K%22">Suita K</searchLink>; Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan.; Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Ishikawa+M%22">Ishikawa M</searchLink>; Department of Oral Anatomy, Tsurumi University School of Dental Medicine, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Mototani+Y%22">Mototani Y</searchLink>; Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Nariyama+M%22">Nariyama M</searchLink>; Department of Pediatric Dentistry, Tsurumi University School of Dental Medicine, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Ito+A%22">Ito A</searchLink>; Department of Orthodontics, Tsurumi University School of Dental Medicine, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Matsuo+I%22">Matsuo I</searchLink>; Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan.; Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Japan.; Department of Periodontology, Tsurumi University School of Dental Medicine, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Hayakawa+Y%22">Hayakawa Y</searchLink>; Department of Dental Anesthesiology, Tsurumi University School of Dental Medicine, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Morii+A%22">Morii A</searchLink>; Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan.; Department of Periodontology, Tsurumi University School of Dental Medicine, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Mitsubayashi+T%22">Mitsubayashi T</searchLink>; Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Saeki+Y%22">Saeki Y</searchLink>; Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Ishikawa+Y%22">Ishikawa Y</searchLink>; Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Okumura+S%22">Okumura S</searchLink>; Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan.; Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
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