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A nitroalkene derivative of salicylate, SANA, induces creatine-dependent thermogenesis and promotes weight loss.

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Title: A nitroalkene derivative of salicylate, SANA, induces creatine-dependent thermogenesis and promotes weight loss.
Authors: Cal K; Laboratory of Metabolic Diseases and Aging, Institut Pasteur Montevideo, Montevideo, Uruguay.; Unidad Biofísica, Departamento de Biociencias, Facultad de Veterinaria, Udelar, Montevideo, Uruguay.; Eolo USA, Wilmington, DE, USA., Leyva A; Laboratory of Vascular Biology and Drug Development, Institut Pasteur Montevideo, Montevideo, Uruguay.; Unidad de Bioquímica y Proteómica Analíticas, Institut Pasteur Montevideo and IIBCE, Montevideo, Uruguay., Rodríguez-Duarte J; Laboratory of Metabolic Diseases and Aging, Institut Pasteur Montevideo, Montevideo, Uruguay.; Laboratory of Vascular Biology and Drug Development, Institut Pasteur Montevideo, Montevideo, Uruguay., Ruiz S; Laboratory of Metabolic Diseases and Aging, Institut Pasteur Montevideo, Montevideo, Uruguay., Santos L; Laboratory of Metabolic Diseases and Aging, Institut Pasteur Montevideo, Montevideo, Uruguay.; Eolo USA, Wilmington, DE, USA., Garat MP; Laboratory of Metabolic Diseases and Aging, Institut Pasteur Montevideo, Montevideo, Uruguay.; Eolo USA, Wilmington, DE, USA., Colella L; Laboratory of Vascular Biology and Drug Development, Institut Pasteur Montevideo, Montevideo, Uruguay.; Departamento de Química Orgánica, Facultad de Química, Udelar, Montevideo, Uruguay., Ingold M; Eolo USA, Wilmington, DE, USA.; Laboratory of Vascular Biology and Drug Development, Institut Pasteur Montevideo, Montevideo, Uruguay.; Departamento de Química Orgánica, Facultad de Química, Udelar, Montevideo, Uruguay., Benitez-Rosendo A; Laboratory of Metabolic Diseases and Aging, Institut Pasteur Montevideo, Montevideo, Uruguay.; Unidad Biofísica, Departamento de Biociencias, Facultad de Veterinaria, Udelar, Montevideo, Uruguay.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Jacksonville, FL, USA., Pérez-Torrado V; Laboratory of Metabolic Diseases and Aging, Institut Pasteur Montevideo, Montevideo, Uruguay.; Eolo USA, Wilmington, DE, USA., Vilaseca C; Departamento de Fisiología, Facultad de Medicina, Udelar, Montevideo, Uruguay., Galliussi G; Laboratory of Vascular Biology and Drug Development, Institut Pasteur Montevideo, Montevideo, Uruguay.; Laboratory of Immunoregulation and Inflammation; Institut Pasteur Montevideo, Montevideo, Uruguay., Ziegler L; Departamento de Ecología y Gestión Ambiental, Centro Universitario Regional del Este, Udelar, Maldonado, Uruguay., Peclat TR; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Jacksonville, FL, USA.; Department of Anesthesiology, Mayo Clinic, Jacksonville, FL, USA.; Department of Physiology and Biomedical Engineering; Mayo Clinic, Jacksonville, FL, USA., Bresque M; Laboratory of Metabolic Diseases and Aging, Institut Pasteur Montevideo, Montevideo, Uruguay.; Eolo USA, Wilmington, DE, USA., Handy RM; Department of Human Health and Nutritional Sciences, University of Guelph, Ontario, Canada., King R; Department of Biochemistry and Molecular Medicine, West Virginia University, Morgantown, WV, USA., Menezes Dos Reis L; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology, and Immunology, Institute of Biology, University of Campinas, Campinas, Brazil.; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.; Obesity and Comorbidities Research Center (OCRC), University of Campinas, Campinas, Brazil.; Experimental Medicine Research Cluster (EMRC), University of Campinas, Campinas, Brazil., Alves JM; Department of Pharmacology, Ribeirão Preto Medical School; Department of Cell Biology, Ribeirão Preto Medical School; and Center for Research in Inflammatory Diseases, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Espasandín C; Laboratory of Metabolic Diseases and Aging, Institut Pasteur Montevideo, Montevideo, Uruguay.; Unidad Bioquímica, Departamento de Biociencias, Facultad de Veterinaria, Udelar, Montevideo, Uruguay., de la Sovera V; Laboratory of Vascular Biology and Drug Development, Institut Pasteur Montevideo, Montevideo, Uruguay.; Departamento de Química Orgánica, Facultad de Química, Udelar, Montevideo, Uruguay., Breining P; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Dapueto R; Laboratory of Metabolic Diseases and Aging, Institut Pasteur Montevideo, Montevideo, Uruguay.; Laboratory of Vascular Biology and Drug Development, Institut Pasteur Montevideo, Montevideo, Uruguay.; Área I+D Biomédico, CUDIM, Montevideo, Uruguay., Lopez A; Laboratorio de Fisicoquímica Orgánica, Departamento de Química del Litoral, CENUR Litoral Norte, Udelar, Paysandú, Uruguay., Thompson KL; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Jacksonville, FL, USA.; Department of Anesthesiology, Mayo Clinic, Jacksonville, FL, USA.; Department of Physiology and Biomedical Engineering; Mayo Clinic, Jacksonville, FL, USA., Lino CA; Institute of Biomedical Sciences, University of Sao Paulo, São Paulo, Brazil., França JV; Institute of Biomedical Sciences, University of Sao Paulo, São Paulo, Brazil., Vieira TS; Institute of Biomedical Sciences, University of Sao Paulo, São Paulo, Brazil., Rattan R; Division of Gynecology Oncology, Department of Women's Health Services, Henry Ford Health, Detroit, MI, USA., Agorrody G; Departamento de Fisiopatología, Hospital de Clínicas, Facultad de Medicina, Udelar, Montevideo, Uruguay., DeVallance E; Department of Physiology and Pharmacology, West Virginia University, Morgantown, WV, USA., Haag J; Eolo USA, Wilmington, DE, USA., Meadows E; Mitochondria, Metabolism and Bioenergetics Working Group; School of Medicine, West Virginia University, Morgantown, WV, USA., Lewis SE; Department of Physiology and Pharmacology, West Virginia University, Morgantown, WV, USA.; Mitochondria, Metabolism and Bioenergetics Working Group; School of Medicine, West Virginia University, Morgantown, WV, USA.; Center for Inhalation Toxicology (iTOX), School of Medicine, West Virginia University, Morgantown, WV, USA., Santana Barbosa GC; Program in Cellular Biochemistry and Biophysics, Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Lai de Souza LO; Program in Cellular Biochemistry and Biophysics, Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Chichierchio MS; Program in Cellular Biochemistry and Biophysics, Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Valez V; Cátedra de Bioquímica y Biofísica, Facultad de Odontología, Udelar, Montevideo, Uruguay.; Centro de Investigaciones Biomédicas (CEINBIO), Udelar, Montevideo, Uruguay.; Departamento de Bioquímica, Facultad de Medicina, Udelar, Montevideo, Uruguay., Aicardo A; Centro de Investigaciones Biomédicas (CEINBIO), Udelar, Montevideo, Uruguay.; Departamento de Bioquímica, Facultad de Medicina, Udelar, Montevideo, Uruguay.; Departamento de Nutrición Clínica, Escuela de Nutrición, Udelar, Montevideo, Uruguay., Contreras P; Laboratory of Metabolic Diseases and Aging, Institut Pasteur Montevideo, Montevideo, Uruguay.; Departamento de Fisiología, Facultad de Medicina, Udelar, Montevideo, Uruguay., Vendelbo MH; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Department of Nuclear Medicine and PET, Aarhus University Hospital, Aarhus, Denmark., Jakobsen S; Department of Nuclear Medicine and PET, Aarhus University Hospital, Aarhus, Denmark., Kamaid A; Laboratory of Vascular Biology and Drug Development, Institut Pasteur Montevideo, Montevideo, Uruguay.; Unidad de Bioquímica y Proteómica Analíticas, Institut Pasteur Montevideo and IIBCE, Montevideo, Uruguay.; Unidad de Bioimagenología Avanzada. Institut Pasteur Montevideo, Montevideo, Uruguay., Porcal W; Laboratory of Vascular Biology and Drug Development, Institut Pasteur Montevideo, Montevideo, Uruguay.; Departamento de Química Orgánica, Facultad de Química, Udelar, Montevideo, Uruguay., Calliari A; Laboratory of Metabolic Diseases and Aging, Institut Pasteur Montevideo, Montevideo, Uruguay.; Unidad Biofísica, Departamento de Biociencias, Facultad de Veterinaria, Udelar, Montevideo, Uruguay., Verdes JM; Unidad Patología, Departamento de Patobiología, Facultad de Veterinaria, Udelar, Montevideo, Uruguay., Du J; Mitochondria, Metabolism and Bioenergetics Working Group; School of Medicine, West Virginia University, Morgantown, WV, USA.; Department of Ophthalmology and Visual Sciences, Department of Biochemistry, West Virginia University, Morgantown, WV, USA., Wang Y; Department of Ophthalmology and Visual Sciences, Department of Biochemistry, West Virginia University, Morgantown, WV, USA., Hollander JM; Mitochondria, Metabolism and Bioenergetics Working Group; School of Medicine, West Virginia University, Morgantown, WV, USA.; Division of Exercise Physiology, West Virginia University, Morgantown, WV, USA., White TA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Jacksonville, FL, USA., Radi R; Centro de Investigaciones Biomédicas (CEINBIO), Udelar, Montevideo, Uruguay.; Departamento de Bioquímica, Facultad de Medicina, Udelar, Montevideo, Uruguay., Moyna G; Laboratorio de Fisicoquímica Orgánica, Departamento de Química del Litoral, CENUR Litoral Norte, Udelar, Paysandú, Uruguay., Quijano C; Centro de Investigaciones Biomédicas (CEINBIO), Udelar, Montevideo, Uruguay.; Departamento de Bioquímica, Facultad de Medicina, Udelar, Montevideo, Uruguay., O'Doherty R; Department of Medicine, Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA., Moraes-Vieira P; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology, and Immunology, Institute of Biology, University of Campinas, Campinas, Brazil.; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.; Obesity and Comorbidities Research Center (OCRC), University of Campinas, Campinas, Brazil.; Experimental Medicine Research Cluster (EMRC), University of Campinas, Campinas, Brazil., Giri S; Department of Neurology, Henry Ford Health, Detroit, MI, USA., Holloway GP; Department of Human Health and Nutritional Sciences, University of Guelph, Ontario, Canada., Festuccia WT; Institute of Biomedical Sciences, University of Sao Paulo, São Paulo, Brazil., Leiria LO; Department of Pharmacology, Ribeirão Preto Medical School; Department of Cell Biology, Ribeirão Preto Medical School; and Center for Research in Inflammatory Diseases, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Leonardi R; Department of Biochemistry and Molecular Medicine, West Virginia University, Morgantown, WV, USA.; Mitochondria, Metabolism and Bioenergetics Working Group; School of Medicine, West Virginia University, Morgantown, WV, USA., Mori MA; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, Brazil.; Obesity and Comorbidities Research Center (OCRC), Campinas, Brazil.; Experimental Medicine Research Cluster (EMRC), Campinas, Brazil.; Instituto Nacional de Obesidade e Diabetes, Campinas, Brazil., Camacho-Pereira J; Program in Cellular Biochemistry and Biophysics, Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Kelley EE; Department of Physiology and Pharmacology, West Virginia University, Morgantown, WV, USA.; Mitochondria, Metabolism and Bioenergetics Working Group; School of Medicine, West Virginia University, Morgantown, WV, USA.; Center for Inhalation Toxicology (iTOX), School of Medicine, West Virginia University, Morgantown, WV, USA., Duran R; Unidad de Bioquímica y Proteómica Analíticas, Institut Pasteur Montevideo and IIBCE, Montevideo, Uruguay., López GV; Laboratory of Vascular Biology and Drug Development, Institut Pasteur Montevideo, Montevideo, Uruguay.; Departamento de Química Orgánica, Facultad de Química, Udelar, Montevideo, Uruguay., Chini EN; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Jacksonville, FL, USA. chini.eduardo@mayo.edu.; Department of Anesthesiology, Mayo Clinic, Jacksonville, FL, USA. chini.eduardo@mayo.edu.; Department of Physiology and Biomedical Engineering; Mayo Clinic, Jacksonville, FL, USA. chini.eduardo@mayo.edu.; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Jacksonville, FL, USA. chini.eduardo@mayo.edu., Batthyány C; Laboratory of Vascular Biology and Drug Development, Institut Pasteur Montevideo, Montevideo, Uruguay. batthyany@pasteur.edu.uy., Escande C; Laboratory of Metabolic Diseases and Aging, Institut Pasteur Montevideo, Montevideo, Uruguay. escande@pasteur.edu.uy.
Source: Nature metabolism [Nat Metab] 2025 Aug; Vol. 7 (8), pp. 1550-1569. Date of Electronic Publication: 2025 Jun 17.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase I
Journal Info: Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab Subsets: MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
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PubType: Academic Journal
PubTypeId: academicJournal
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: A nitroalkene derivative of salicylate, SANA, induces creatine-dependent thermogenesis and promotes weight loss.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Cal+K%22">Cal K</searchLink>; Laboratory of Metabolic Diseases and Aging, Institut Pasteur Montevideo, Montevideo, Uruguay.; Unidad Biofísica, Departamento de Biociencias, Facultad de Veterinaria, Udelar, Montevideo, Uruguay.; Eolo USA, Wilmington, DE, USA.<br /><searchLink fieldCode="AU" term="%22Leyva+A%22">Leyva A</searchLink>; Laboratory of Vascular Biology and Drug Development, Institut Pasteur Montevideo, Montevideo, Uruguay.; Unidad de Bioquímica y Proteómica Analíticas, Institut Pasteur Montevideo and IIBCE, Montevideo, Uruguay.<br /><searchLink fieldCode="AU" term="%22Rodríguez-Duarte+J%22">Rodríguez-Duarte J</searchLink>; Laboratory of Metabolic Diseases and Aging, Institut Pasteur Montevideo, Montevideo, Uruguay.; Laboratory of Vascular Biology and Drug Development, Institut Pasteur Montevideo, Montevideo, Uruguay.<br /><searchLink fieldCode="AU" term="%22Ruiz+S%22">Ruiz S</searchLink>; Laboratory of Metabolic Diseases and Aging, Institut Pasteur Montevideo, Montevideo, Uruguay.<br /><searchLink fieldCode="AU" term="%22Santos+L%22">Santos L</searchLink>; Laboratory of Metabolic Diseases and Aging, Institut Pasteur Montevideo, Montevideo, Uruguay.; Eolo USA, Wilmington, DE, USA.<br /><searchLink fieldCode="AU" term="%22Garat+MP%22">Garat MP</searchLink>; Laboratory of Metabolic Diseases and Aging, Institut Pasteur Montevideo, Montevideo, Uruguay.; Eolo USA, Wilmington, DE, USA.<br /><searchLink fieldCode="AU" term="%22Colella+L%22">Colella L</searchLink>; Laboratory of Vascular Biology and Drug Development, Institut Pasteur Montevideo, Montevideo, Uruguay.; Departamento de Química Orgánica, Facultad de Química, Udelar, Montevideo, Uruguay.<br /><searchLink fieldCode="AU" term="%22Ingold+M%22">Ingold M</searchLink>; Eolo USA, Wilmington, DE, USA.; Laboratory of Vascular Biology and Drug Development, Institut Pasteur Montevideo, Montevideo, Uruguay.; Departamento de Química Orgánica, Facultad de Química, Udelar, Montevideo, Uruguay.<br /><searchLink fieldCode="AU" term="%22Benitez-Rosendo+A%22">Benitez-Rosendo A</searchLink>; Laboratory of Metabolic Diseases and Aging, Institut Pasteur Montevideo, Montevideo, Uruguay.; Unidad Biofísica, Departamento de Biociencias, Facultad de Veterinaria, Udelar, Montevideo, Uruguay.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Jacksonville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Pérez-Torrado+V%22">Pérez-Torrado V</searchLink>; Laboratory of Metabolic Diseases and Aging, Institut Pasteur Montevideo, Montevideo, Uruguay.; Eolo USA, Wilmington, DE, USA.<br /><searchLink fieldCode="AU" term="%22Vilaseca+C%22">Vilaseca C</searchLink>; Departamento de Fisiología, Facultad de Medicina, Udelar, Montevideo, Uruguay.<br /><searchLink fieldCode="AU" term="%22Galliussi+G%22">Galliussi G</searchLink>; Laboratory of Vascular Biology and Drug Development, Institut Pasteur Montevideo, Montevideo, Uruguay.; Laboratory of Immunoregulation and Inflammation; Institut Pasteur Montevideo, Montevideo, Uruguay.<br /><searchLink fieldCode="AU" term="%22Ziegler+L%22">Ziegler L</searchLink>; Departamento de Ecología y Gestión Ambiental, Centro Universitario Regional del Este, Udelar, Maldonado, Uruguay.<br /><searchLink fieldCode="AU" term="%22Peclat+TR%22">Peclat TR</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Jacksonville, FL, USA.; Department of Anesthesiology, Mayo Clinic, Jacksonville, FL, USA.; Department of Physiology and Biomedical Engineering; Mayo Clinic, Jacksonville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Bresque+M%22">Bresque M</searchLink>; Laboratory of Metabolic Diseases and Aging, Institut Pasteur Montevideo, Montevideo, Uruguay.; Eolo USA, Wilmington, DE, USA.<br /><searchLink fieldCode="AU" term="%22Handy+RM%22">Handy RM</searchLink>; Department of Human Health and Nutritional Sciences, University of Guelph, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22King+R%22">King R</searchLink>; Department of Biochemistry and Molecular Medicine, West Virginia University, Morgantown, WV, USA.<br /><searchLink fieldCode="AU" term="%22Menezes+Dos+Reis+L%22">Menezes Dos Reis L</searchLink>; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology, and Immunology, Institute of Biology, University of Campinas, Campinas, Brazil.; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.; Obesity and Comorbidities Research Center (OCRC), University of Campinas, Campinas, Brazil.; Experimental Medicine Research Cluster (EMRC), University of Campinas, Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Alves+JM%22">Alves JM</searchLink>; Department of Pharmacology, Ribeirão Preto Medical School; Department of Cell Biology, Ribeirão Preto Medical School; and Center for Research in Inflammatory Diseases, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.<br /><searchLink fieldCode="AU" term="%22Espasandín+C%22">Espasandín C</searchLink>; Laboratory of Metabolic Diseases and Aging, Institut Pasteur Montevideo, Montevideo, Uruguay.; Unidad Bioquímica, Departamento de Biociencias, Facultad de Veterinaria, Udelar, Montevideo, Uruguay.<br /><searchLink fieldCode="AU" term="%22de+la+Sovera+V%22">de la Sovera V</searchLink>; Laboratory of Vascular Biology and Drug Development, Institut Pasteur Montevideo, Montevideo, Uruguay.; Departamento de Química Orgánica, Facultad de Química, Udelar, Montevideo, Uruguay.<br /><searchLink fieldCode="AU" term="%22Breining+P%22">Breining P</searchLink>; Department of Biomedicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Dapueto+R%22">Dapueto R</searchLink>; Laboratory of Metabolic Diseases and Aging, Institut Pasteur Montevideo, Montevideo, Uruguay.; Laboratory of Vascular Biology and Drug Development, Institut Pasteur Montevideo, Montevideo, Uruguay.; Área I+D Biomédico, CUDIM, Montevideo, Uruguay.<br /><searchLink fieldCode="AU" term="%22Lopez+A%22">Lopez A</searchLink>; Laboratorio de Fisicoquímica Orgánica, Departamento de Química del Litoral, CENUR Litoral Norte, Udelar, Paysandú, Uruguay.<br /><searchLink fieldCode="AU" term="%22Thompson+KL%22">Thompson KL</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Jacksonville, FL, USA.; Department of Anesthesiology, Mayo Clinic, Jacksonville, FL, USA.; Department of Physiology and Biomedical Engineering; Mayo Clinic, Jacksonville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Lino+CA%22">Lino CA</searchLink>; Institute of Biomedical Sciences, University of Sao Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22França+JV%22">França JV</searchLink>; Institute of Biomedical Sciences, University of Sao Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Vieira+TS%22">Vieira TS</searchLink>; Institute of Biomedical Sciences, University of Sao Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Rattan+R%22">Rattan R</searchLink>; Division of Gynecology Oncology, Department of Women's Health Services, Henry Ford Health, Detroit, MI, USA.<br /><searchLink fieldCode="AU" term="%22Agorrody+G%22">Agorrody G</searchLink>; Departamento de Fisiopatología, Hospital de Clínicas, Facultad de Medicina, Udelar, Montevideo, Uruguay.<br /><searchLink fieldCode="AU" term="%22DeVallance+E%22">DeVallance E</searchLink>; Department of Physiology and Pharmacology, West Virginia University, Morgantown, WV, USA.<br /><searchLink fieldCode="AU" term="%22Haag+J%22">Haag J</searchLink>; Eolo USA, Wilmington, DE, USA.<br /><searchLink fieldCode="AU" term="%22Meadows+E%22">Meadows E</searchLink>; Mitochondria, Metabolism and Bioenergetics Working Group; School of Medicine, West Virginia University, Morgantown, WV, USA.<br /><searchLink fieldCode="AU" term="%22Lewis+SE%22">Lewis SE</searchLink>; Department of Physiology and Pharmacology, West Virginia University, Morgantown, WV, USA.; Mitochondria, Metabolism and Bioenergetics Working Group; School of Medicine, West Virginia University, Morgantown, WV, USA.; Center for Inhalation Toxicology (iTOX), School of Medicine, West Virginia University, Morgantown, WV, USA.<br /><searchLink fieldCode="AU" term="%22Santana+Barbosa+GC%22">Santana Barbosa GC</searchLink>; Program in Cellular Biochemistry and Biophysics, Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Lai+de+Souza+LO%22">Lai de Souza LO</searchLink>; Program in Cellular Biochemistry and Biophysics, Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Chichierchio+MS%22">Chichierchio MS</searchLink>; Program in Cellular Biochemistry and Biophysics, Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Valez+V%22">Valez V</searchLink>; Cátedra de Bioquímica y Biofísica, Facultad de Odontología, Udelar, Montevideo, Uruguay.; Centro de Investigaciones Biomédicas (CEINBIO), Udelar, Montevideo, Uruguay.; Departamento de Bioquímica, Facultad de Medicina, Udelar, Montevideo, Uruguay.<br /><searchLink fieldCode="AU" term="%22Aicardo+A%22">Aicardo A</searchLink>; Centro de Investigaciones Biomédicas (CEINBIO), Udelar, Montevideo, Uruguay.; Departamento de Bioquímica, Facultad de Medicina, Udelar, Montevideo, Uruguay.; Departamento de Nutrición Clínica, Escuela de Nutrición, Udelar, Montevideo, Uruguay.<br /><searchLink fieldCode="AU" term="%22Contreras+P%22">Contreras P</searchLink>; Laboratory of Metabolic Diseases and Aging, Institut Pasteur Montevideo, Montevideo, Uruguay.; Departamento de Fisiología, Facultad de Medicina, Udelar, Montevideo, Uruguay.<br /><searchLink fieldCode="AU" term="%22Vendelbo+MH%22">Vendelbo MH</searchLink>; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Department of Nuclear Medicine and PET, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Jakobsen+S%22">Jakobsen S</searchLink>; Department of Nuclear Medicine and PET, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Kamaid+A%22">Kamaid A</searchLink>; Laboratory of Vascular Biology and Drug Development, Institut Pasteur Montevideo, Montevideo, Uruguay.; Unidad de Bioquímica y Proteómica Analíticas, Institut Pasteur Montevideo and IIBCE, Montevideo, Uruguay.; Unidad de Bioimagenología Avanzada. Institut Pasteur Montevideo, Montevideo, Uruguay.<br /><searchLink fieldCode="AU" term="%22Porcal+W%22">Porcal W</searchLink>; Laboratory of Vascular Biology and Drug Development, Institut Pasteur Montevideo, Montevideo, Uruguay.; Departamento de Química Orgánica, Facultad de Química, Udelar, Montevideo, Uruguay.<br /><searchLink fieldCode="AU" term="%22Calliari+A%22">Calliari A</searchLink>; Laboratory of Metabolic Diseases and Aging, Institut Pasteur Montevideo, Montevideo, Uruguay.; Unidad Biofísica, Departamento de Biociencias, Facultad de Veterinaria, Udelar, Montevideo, Uruguay.<br /><searchLink fieldCode="AU" term="%22Verdes+JM%22">Verdes JM</searchLink>; Unidad Patología, Departamento de Patobiología, Facultad de Veterinaria, Udelar, Montevideo, Uruguay.<br /><searchLink fieldCode="AU" term="%22Du+J%22">Du J</searchLink>; Mitochondria, Metabolism and Bioenergetics Working Group; School of Medicine, West Virginia University, Morgantown, WV, USA.; Department of Ophthalmology and Visual Sciences, Department of Biochemistry, West Virginia University, Morgantown, WV, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Ophthalmology and Visual Sciences, Department of Biochemistry, West Virginia University, Morgantown, WV, USA.<br /><searchLink fieldCode="AU" term="%22Hollander+JM%22">Hollander JM</searchLink>; Mitochondria, Metabolism and Bioenergetics Working Group; School of Medicine, West Virginia University, Morgantown, WV, USA.; Division of Exercise Physiology, West Virginia University, Morgantown, WV, USA.<br /><searchLink fieldCode="AU" term="%22White+TA%22">White TA</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Jacksonville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Radi+R%22">Radi R</searchLink>; Centro de Investigaciones Biomédicas (CEINBIO), Udelar, Montevideo, Uruguay.; Departamento de Bioquímica, Facultad de Medicina, Udelar, Montevideo, Uruguay.<br /><searchLink fieldCode="AU" term="%22Moyna+G%22">Moyna G</searchLink>; Laboratorio de Fisicoquímica Orgánica, Departamento de Química del Litoral, CENUR Litoral Norte, Udelar, Paysandú, Uruguay.<br /><searchLink fieldCode="AU" term="%22Quijano+C%22">Quijano C</searchLink>; Centro de Investigaciones Biomédicas (CEINBIO), Udelar, Montevideo, Uruguay.; Departamento de Bioquímica, Facultad de Medicina, Udelar, Montevideo, Uruguay.<br /><searchLink fieldCode="AU" term="%22O'Doherty+R%22">O'Doherty R</searchLink>; Department of Medicine, Division of Endocrinology and Metabolism, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Moraes-Vieira+P%22">Moraes-Vieira P</searchLink>; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology, and Immunology, Institute of Biology, University of Campinas, Campinas, Brazil.; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.; Obesity and Comorbidities Research Center (OCRC), University of Campinas, Campinas, Brazil.; Experimental Medicine Research Cluster (EMRC), University of Campinas, Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Giri+S%22">Giri S</searchLink>; Department of Neurology, Henry Ford Health, Detroit, MI, USA.<br /><searchLink fieldCode="AU" term="%22Holloway+GP%22">Holloway GP</searchLink>; Department of Human Health and Nutritional Sciences, University of Guelph, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Festuccia+WT%22">Festuccia WT</searchLink>; Institute of Biomedical Sciences, University of Sao Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Leiria+LO%22">Leiria LO</searchLink>; Department of Pharmacology, Ribeirão Preto Medical School; Department of Cell Biology, Ribeirão Preto Medical School; and Center for Research in Inflammatory Diseases, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.<br /><searchLink fieldCode="AU" term="%22Leonardi+R%22">Leonardi R</searchLink>; Department of Biochemistry and Molecular Medicine, West Virginia University, Morgantown, WV, USA.; Mitochondria, Metabolism and Bioenergetics Working Group; School of Medicine, West Virginia University, Morgantown, WV, USA.<br /><searchLink fieldCode="AU" term="%22Mori+MA%22">Mori MA</searchLink>; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, Brazil.; Obesity and Comorbidities Research Center (OCRC), Campinas, Brazil.; Experimental Medicine Research Cluster (EMRC), Campinas, Brazil.; Instituto Nacional de Obesidade e Diabetes, Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Camacho-Pereira+J%22">Camacho-Pereira J</searchLink>; Program in Cellular Biochemistry and Biophysics, Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Kelley+EE%22">Kelley EE</searchLink>; Department of Physiology and Pharmacology, West Virginia University, Morgantown, WV, USA.; Mitochondria, Metabolism and Bioenergetics Working Group; School of Medicine, West Virginia University, Morgantown, WV, USA.; Center for Inhalation Toxicology (iTOX), School of Medicine, West Virginia University, Morgantown, WV, USA.<br /><searchLink fieldCode="AU" term="%22Duran+R%22">Duran R</searchLink>; Unidad de Bioquímica y Proteómica Analíticas, Institut Pasteur Montevideo and IIBCE, Montevideo, Uruguay.<br /><searchLink fieldCode="AU" term="%22López+GV%22">López GV</searchLink>; Laboratory of Vascular Biology and Drug Development, Institut Pasteur Montevideo, Montevideo, Uruguay.; Departamento de Química Orgánica, Facultad de Química, Udelar, Montevideo, Uruguay.<br /><searchLink fieldCode="AU" term="%22Chini+EN%22">Chini EN</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Jacksonville, FL, USA. chini.eduardo@mayo.edu.; Department of Anesthesiology, Mayo Clinic, Jacksonville, FL, USA. chini.eduardo@mayo.edu.; Department of Physiology and Biomedical Engineering; Mayo Clinic, Jacksonville, FL, USA. chini.eduardo@mayo.edu.; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Jacksonville, FL, USA. chini.eduardo@mayo.edu.<br /><searchLink fieldCode="AU" term="%22Batthyány+C%22">Batthyány C</searchLink>; Laboratory of Vascular Biology and Drug Development, Institut Pasteur Montevideo, Montevideo, Uruguay. batthyany@pasteur.edu.uy.<br /><searchLink fieldCode="AU" term="%22Escande+C%22">Escande C</searchLink>; Laboratory of Metabolic Diseases and Aging, Institut Pasteur Montevideo, Montevideo, Uruguay. escande@pasteur.edu.uy.
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  Data: <searchLink fieldCode="JN" term="%22101736592%22">Nature metabolism</searchLink> [Nat Metab] 2025 Aug; Vol. 7 (8), pp. 1550-1569. <i>Date of Electronic Publication: </i>2025 Jun 17.
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