View in EDS

Design, Synthesis, and In Vitro Characterization of a Tryptamine-Based Visible-Light Photoswitchable 5-HT2AR Ligand Showing Efficacy Preference for β-Arrestin over Mini-Gq.

Saved in:
Bibliographic Details
Title: Design, Synthesis, and In Vitro Characterization of a Tryptamine-Based Visible-Light Photoswitchable 5-HT2AR Ligand Showing Efficacy Preference for β-Arrestin over Mini-Gq.
Authors: Sink A; Institut für Pharmazie und Lebensmittelchemie, Pharmazeutische und Medizinische Chemie, Julius-Maximilians-Universität Würzburg (JMU), Am Hubland, Würzburg 97074 Germany., Pottie E; Laboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent B-9000, Belgium., Carter SJ; Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, United States.; Institute for Psychedelics and Neurotherapeutics, University of California, Davis, Davis, California 95616, United States., Tombari RJ; Chemistry and Chemical Biology Graduate Program, University of California, Davis, Davis, California 95616, United States., Weber V; Institute for Neuroscience and Medicine (INM-9), Computational Biomedicine, Forschungszentrum Jülich, Wilhelm-Johnen-Straße, Jülich 52425, Germany.; Department of Chemistry, Faculty of Mathematics, Computer Science and Natural Sciences, RWTH Aachen University institution, Aachen 52062, Germany., Carloni P; Institute for Neuroscience and Medicine (INM-9), Computational Biomedicine, Forschungszentrum Jülich, Wilhelm-Johnen-Straße, Jülich 52425, Germany.; Department of Physics, Faculty of Mathematics, Computer Science and Natural Sciences, RWTH Aachen University, Aachen 52062, Germany., Rossetti G; Institute for Neuroscience and Medicine (INM-9), Computational Biomedicine, Forschungszentrum Jülich, Wilhelm-Johnen-Straße, Jülich 52425, Germany.; Jülich Supercomputing Center, Forschungszentrum Jülich, Wilhelm-Johnen-Straße, Jülich 52425, Germany.; Department of Neurology, University Hospital Aachen, RWTH Aachen University, Pauwelsstraße 30, Aachen 52074, Germany., Olson DE; Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, United States.; Institute for Psychedelics and Neurotherapeutics, University of California, Davis, Davis, California 95616, United States.; Department of Biochemistry & Molecular Medicine, School of Medicine, University of California, Davis, 2700 Stockton Blvd, Suite 2102, Sacramento, California 95817, United States.; Center for Neuroscience, University of California, Davis, 1544 Newton Ct, Davis, California 95618, United States., Stove CP; Laboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent B-9000, Belgium., Decker M; Institut für Pharmazie und Lebensmittelchemie, Pharmazeutische und Medizinische Chemie, Julius-Maximilians-Universität Würzburg (JMU), Am Hubland, Würzburg 97074 Germany.
Source: Journal of medicinal chemistry [J Med Chem] 2025 Jul 10; Vol. 68 (13), pp. 13628-13639. Date of Electronic Publication: 2025 Jun 18.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 40532050
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Design, Synthesis, and In Vitro Characterization of a Tryptamine-Based Visible-Light Photoswitchable 5-HT<subscript>2A</subscript>R Ligand Showing Efficacy Preference for β-Arrestin over Mini-Gq.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Sink+A%22">Sink A</searchLink>; Institut für Pharmazie und Lebensmittelchemie, Pharmazeutische und Medizinische Chemie, Julius-Maximilians-Universität Würzburg (JMU), Am Hubland, Würzburg 97074 Germany.<br /><searchLink fieldCode="AU" term="%22Pottie+E%22">Pottie E</searchLink>; Laboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent B-9000, Belgium.<br /><searchLink fieldCode="AU" term="%22Carter+SJ%22">Carter SJ</searchLink>; Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, United States.; Institute for Psychedelics and Neurotherapeutics, University of California, Davis, Davis, California 95616, United States.<br /><searchLink fieldCode="AU" term="%22Tombari+RJ%22">Tombari RJ</searchLink>; Chemistry and Chemical Biology Graduate Program, University of California, Davis, Davis, California 95616, United States.<br /><searchLink fieldCode="AU" term="%22Weber+V%22">Weber V</searchLink>; Institute for Neuroscience and Medicine (INM-9), Computational Biomedicine, Forschungszentrum Jülich, Wilhelm-Johnen-Straße, Jülich 52425, Germany.; Department of Chemistry, Faculty of Mathematics, Computer Science and Natural Sciences, RWTH Aachen University institution, Aachen 52062, Germany.<br /><searchLink fieldCode="AU" term="%22Carloni+P%22">Carloni P</searchLink>; Institute for Neuroscience and Medicine (INM-9), Computational Biomedicine, Forschungszentrum Jülich, Wilhelm-Johnen-Straße, Jülich 52425, Germany.; Department of Physics, Faculty of Mathematics, Computer Science and Natural Sciences, RWTH Aachen University, Aachen 52062, Germany.<br /><searchLink fieldCode="AU" term="%22Rossetti+G%22">Rossetti G</searchLink>; Institute for Neuroscience and Medicine (INM-9), Computational Biomedicine, Forschungszentrum Jülich, Wilhelm-Johnen-Straße, Jülich 52425, Germany.; Jülich Supercomputing Center, Forschungszentrum Jülich, Wilhelm-Johnen-Straße, Jülich 52425, Germany.; Department of Neurology, University Hospital Aachen, RWTH Aachen University, Pauwelsstraße 30, Aachen 52074, Germany.<br /><searchLink fieldCode="AU" term="%22Olson+DE%22">Olson DE</searchLink>; Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, United States.; Institute for Psychedelics and Neurotherapeutics, University of California, Davis, Davis, California 95616, United States.; Department of Biochemistry & Molecular Medicine, School of Medicine, University of California, Davis, 2700 Stockton Blvd, Suite 2102, Sacramento, California 95817, United States.; Center for Neuroscience, University of California, Davis, 1544 Newton Ct, Davis, California 95618, United States.<br /><searchLink fieldCode="AU" term="%22Stove+CP%22">Stove CP</searchLink>; Laboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent B-9000, Belgium.<br /><searchLink fieldCode="AU" term="%22Decker+M%22">Decker M</searchLink>; Institut für Pharmazie und Lebensmittelchemie, Pharmazeutische und Medizinische Chemie, Julius-Maximilians-Universität Würzburg (JMU), Am Hubland, Würzburg 97074 Germany.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2025 Jul 10; Vol. 68 (13), pp. 13628-13639. <i>Date of Electronic Publication: </i>2025 Jun 18.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40532050
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1021/acs.jmedchem.5c00442
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 13628
    Titles:
      – TitleFull: Design, Synthesis, and In Vitro Characterization of a Tryptamine-Based Visible-Light Photoswitchable 5-HT2AR Ligand Showing Efficacy Preference for β-Arrestin over Mini-Gq.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Sink A
      – PersonEntity:
          Name:
            NameFull: Pottie E
      – PersonEntity:
          Name:
            NameFull: Carter SJ
      – PersonEntity:
          Name:
            NameFull: Tombari RJ
      – PersonEntity:
          Name:
            NameFull: Weber V
      – PersonEntity:
          Name:
            NameFull: Carloni P
      – PersonEntity:
          Name:
            NameFull: Rossetti G
      – PersonEntity:
          Name:
            NameFull: Olson DE
      – PersonEntity:
          Name:
            NameFull: Stove CP
      – PersonEntity:
          Name:
            NameFull: Decker M
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 10
              M: 07
              Text: 2025 Jul 10
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1520-4804
          Numbering:
            – Type: volume
              Value: 68
            – Type: issue
              Value: 13
          Titles:
            – TitleFull: Journal of medicinal chemistry
              Type: main
ResultId 1