Trithiol ligand provides tumor-targeting 191Pt-complexes with high molar activity and promising in vivo properties.

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Title: Trithiol ligand provides tumor-targeting 191Pt-complexes with high molar activity and promising in vivo properties.
Authors: Obata H; Department of Advanced Nuclear Medicine Sciences, National Institutes for Quantum Science and Technology (QST), 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan; Department of Molecular Imaging and Theranostics, National Institutes for Quantum Science and Technology (QST), 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan; Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA; Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo, Hokkaido 060-0812, Japan. Electronic address: obata.honoka@qst.go.jp., Tsuji AB; Department of Molecular Imaging and Theranostics, National Institutes for Quantum Science and Technology (QST), 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan., Feng Y; Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA., Zheng Y; Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA., Sudo H; Department of Molecular Imaging and Theranostics, National Institutes for Quantum Science and Technology (QST), 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan., Sugyo A; Department of Molecular Imaging and Theranostics, National Institutes for Quantum Science and Technology (QST), 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan., Tornow W; Department of Physics and Triangle Universities Nuclear Laboratory, Duke University, Durham, NC 27710, USA., Finch SW; Department of Physics and Triangle Universities Nuclear Laboratory, Duke University, Durham, NC 27710, USA., Minegishi K; Department of Advanced Nuclear Medicine Sciences, National Institutes for Quantum Science and Technology (QST), 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan., Suzuki H; Department of Advanced Nuclear Medicine Sciences, National Institutes for Quantum Science and Technology (QST), 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan., Ichinose J; Department of Advanced Nuclear Medicine Sciences, National Institutes for Quantum Science and Technology (QST), 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan., Ogawa M; Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo, Hokkaido 060-0812, Japan., Zhang MR; Department of Advanced Nuclear Medicine Sciences, National Institutes for Quantum Science and Technology (QST), 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan., Zalutsky MR; Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: michael.zalutsky@duke.edu.
Source: Nuclear medicine and biology [Nucl Med Biol] 2025 Jul-Aug; Vol. 146-147, pp. 109043. Date of Electronic Publication: 2025 Jun 10.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 9304420 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9614 (Electronic) Linking ISSN: 09698051 NLM ISO Abbreviation: Nucl Med Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1872-9614
DOI:10.1016/j.nucmedbio.2025.109043