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Safety and efficacy of perioperative dual PD-1 and HER2 blockade in HER2-positive gastric cancer.

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Title: Safety and efficacy of perioperative dual PD-1 and HER2 blockade in HER2-positive gastric cancer.
Authors: Nie RC; Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, P.R. China., Chen XJ; Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, P.R. China., Liang CC; Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, P.R. China., Zhao BW; Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, P.R. China., Wang W; Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, P.R. China., Zhang FY; Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, P.R. China., Cai MY; Department of Pathology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, P.R. China., Qiu HB; Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, P.R. China., Xue ZC; Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, P.R. China., Chen GM; Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, P.R. China., Liu ZM; Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, P.R. China., Chi J; Department of Endoscopy, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, P.R. China., Duan JL; Department of Pathology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, P.R. China., Zhang DS; Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University, Guangzhou 510060, P.R. China., Chen YB; Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, P.R. China., Zhou ZW; Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, P.R. China., Chen YM; Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, P.R. China. Electronic address: chenyongm@sysucc.org.cn., Yuan SQ; Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, P.R. China. Electronic address: yuanshq@sysucc.org.cn., Li YF; Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, P.R. China. Electronic address: liyuanf@sysucc.org.cn.
Source: Cell reports. Medicine [Cell Rep Med] 2025 Jun 17; Vol. 6 (6), pp. 102190.
Publication Type: Journal Article; Clinical Trial, Phase II
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Safety and efficacy of perioperative dual PD-1 and HER2 blockade in HER2-positive gastric cancer.
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  Data: <searchLink fieldCode="AU" term="%22Nie+RC%22">Nie RC</searchLink>; Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, P.R. China.<br /><searchLink fieldCode="AU" term="%22Chen+XJ%22">Chen XJ</searchLink>; Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, P.R. China.<br /><searchLink fieldCode="AU" term="%22Liang+CC%22">Liang CC</searchLink>; Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, P.R. China.<br /><searchLink fieldCode="AU" term="%22Zhao+BW%22">Zhao BW</searchLink>; Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, P.R. China.<br /><searchLink fieldCode="AU" term="%22Wang+W%22">Wang W</searchLink>; Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, P.R. China.<br /><searchLink fieldCode="AU" term="%22Zhang+FY%22">Zhang FY</searchLink>; Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, P.R. China.<br /><searchLink fieldCode="AU" term="%22Cai+MY%22">Cai MY</searchLink>; Department of Pathology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, P.R. China.<br /><searchLink fieldCode="AU" term="%22Qiu+HB%22">Qiu HB</searchLink>; Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, P.R. China.<br /><searchLink fieldCode="AU" term="%22Xue+ZC%22">Xue ZC</searchLink>; Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, P.R. China.<br /><searchLink fieldCode="AU" term="%22Chen+GM%22">Chen GM</searchLink>; Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, P.R. China.<br /><searchLink fieldCode="AU" term="%22Liu+ZM%22">Liu ZM</searchLink>; Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, P.R. China.<br /><searchLink fieldCode="AU" term="%22Chi+J%22">Chi J</searchLink>; Department of Endoscopy, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, P.R. China.<br /><searchLink fieldCode="AU" term="%22Duan+JL%22">Duan JL</searchLink>; Department of Pathology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, P.R. China.<br /><searchLink fieldCode="AU" term="%22Zhang+DS%22">Zhang DS</searchLink>; Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University, Guangzhou 510060, P.R. China.<br /><searchLink fieldCode="AU" term="%22Chen+YB%22">Chen YB</searchLink>; Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, P.R. China.<br /><searchLink fieldCode="AU" term="%22Zhou+ZW%22">Zhou ZW</searchLink>; Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, P.R. China.<br /><searchLink fieldCode="AU" term="%22Chen+YM%22">Chen YM</searchLink>; Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, P.R. China. Electronic address: chenyongm@sysucc.org.cn.<br /><searchLink fieldCode="AU" term="%22Yuan+SQ%22">Yuan SQ</searchLink>; Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, P.R. China. Electronic address: yuanshq@sysucc.org.cn.<br /><searchLink fieldCode="AU" term="%22Li+YF%22">Li YF</searchLink>; Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, P.R. China. Electronic address: liyuanf@sysucc.org.cn.
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              Text: 2025 Jun 17
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