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Effects of Sofosbuvir/Velpatasvir Therapy on Extrahepatic Manifestations in Patients With Type 2 Diabetes and Chronic Hepatitis C: Insights From a Nationwide Hepatitis C Virus Registry in Taiwan.

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Title: Effects of Sofosbuvir/Velpatasvir Therapy on Extrahepatic Manifestations in Patients With Type 2 Diabetes and Chronic Hepatitis C: Insights From a Nationwide Hepatitis C Virus Registry in Taiwan.
Authors: Wang SJ; Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Division of Hepatogastroenterology, Department of Internal Medicine, Shin Huey Shin Hospital, Kaohsiung, Taiwan.; Division of Gastroenterology, Department of Internal Medicine, Yuan's General Hospital, Kaohsiung, Taiwan., Chang TS; Division of Hepatogastroenterology, Department of Internal Medicine, ChiaYi Chang Gung Memorial Hospital, Chiayi, Taiwan.; College of Medicine, Chang Gung University, Taoyuan, Taiwan., Lo CC; Division of Gastroenterology, Department of Internal Medicine, St. Martin De Porres Hospital, Chiayi, Taiwan., Hung CH; Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan., Huang CW; Division of Gastroenterology, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan., Chong LW; Division of Hepatology and Gastroenterology, Department of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.; School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan., Cheng PN; Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan., Bair MJ; Division of Gastroenterology, Department of Internal Medicine, Taitung Mackay Memorial Hospital, Taitung, Taiwan.; Mackay Medical College, New Taipei City, Taiwan., Yeh ML; Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Hepatitis Research Center, College of Medicine; Center for Metabolic Disorders and Obesity, Kaohsiung Medical University, Kaohsiung, Taiwan., Peng CY; Center for Digestive Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.; School of Medicine, China Medical University, Taichung, Taiwan., Cheng CY; Division of Infectious Diseases, Department of Internal Medicine, Taoyuan General Hsopital, Ministry of Health and Welfare, Taoyuan, Taiwan., Huang JF; Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Hepatitis Research Center, College of Medicine; Center for Metabolic Disorders and Obesity, Kaohsiung Medical University, Kaohsiung, Taiwan., Lin CL; Liver Research Unit, Department of Hepato Gastroenterology and Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, College of Medicine, Chang Gung University, Keelung, Taiwan., Yang CC; Department of Gastroenterology, Division of Internal Medicine, Show Chwan Memorial Hospital, Changhua, Taiwan., Kuo HT; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan., Hsieh TY; Division of Gastroenterology, Department of Internal Medicine, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan., Lee TH; Division of Gastroenterology and Hepatology, Far Eastern Memorial Hospital, New Taipei City, Taiwan., Lee PL; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chi Mei Medical Center, Liouying, Tainan, Taiwan., Wu WC; Wen-Chih Wu Clinic, Fengshan, Kaohsiung, Taiwan., Lin CL; Department of Gastroenterology, Renai Branch, Taipei City Hospital, Taipei, Taiwan., Su WW; Department of Gastroenterology and Hepatology, Changhua Christian Hospital, Changhua, Taiwan., Yang SS; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan., Wang CC; Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and School of Medicine, Tzu Chi University, Taipei, Taiwan., Hu JT; Liver Center, Cathay General Hospital, Taipei, Taiwan., Mo LR; Division of Gastroenterology, Tainan Municipal Hospital (Managed By Show Chwan Medical Care Corporation), Tainan, Taiwan., Chen CT; Division of Gastroenterology, Department of Internal Medicine tri Service, General Hospital Penghu Branch, National Defense Medical Center, Taipei, Taiwan., Huang YH; Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan.; Institute of Clinical Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Chang CC; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan.; Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan., Huang CS; Yang Ming Hospital, Chiayi, Taiwan., Chen GY; Penghu Hospital, Ministry of Health and Welfare, Penghu, Taiwan., Kao CN; National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan., Tai CM; Division of Gastroenterology and Hepatology, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.; School of Medicine for International Students, College of Medicine, I-Shou University, Kaohsiung, Taiwan., Liu CJ; Hepatitis Research Center and Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan., Lee MH; Institute of Clinical Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Tsai PC; Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Hepatitis Research Center, College of Medicine; Center for Metabolic Disorders and Obesity, Kaohsiung Medical University, Kaohsiung, Taiwan., Wang SC; Hepatitis Research Center, College of Medicine; Center for Metabolic Disorders and Obesity, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan., Dai CY; Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Hepatitis Research Center, College of Medicine; Center for Metabolic Disorders and Obesity, Kaohsiung Medical University, Kaohsiung, Taiwan., Kao JH; Hepatitis Research Center and Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan., Lin HC; Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan.; Institute of Clinical Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Chuang WL; Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Hepatitis Research Center, College of Medicine; Center for Metabolic Disorders and Obesity, Kaohsiung Medical University, Kaohsiung, Taiwan., Tseng KC; School of Medicine, Tzuchi University, Hualien, Taiwan.; Department of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan., Chen CY; Division of Gastroenterology and Hepatology, Department of Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi, Taiwan., Huang CF; Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Hepatitis Research Center, College of Medicine; Center for Metabolic Disorders and Obesity, Kaohsiung Medical University, Kaohsiung, Taiwan.; Ph.D. Program in Translational Medicine, College of Medicine, Kaohsiung Medical University, Academia Sinica, Kaohsiung, Taiwan., Yu ML; Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Hepatitis Research Center, College of Medicine; Center for Metabolic Disorders and Obesity, Kaohsiung Medical University, Kaohsiung, Taiwan.; Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University, Kaohsiung, Taiwan.
Source: The Kaohsiung journal of medical sciences [Kaohsiung J Med Sci] 2025 Nov; Vol. 41 (11), pp. e70067. Date of Electronic Publication: 2025 Jun 20.
Publication Type: Journal Article
Journal Info: Publisher: Department of Public Health, Kaohsiung Medical University Country of Publication: China (Republic : 1949- ) NLM ID: 100960562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2410-8650 (Electronic) Linking ISSN: 1607551X NLM ISO Abbreviation: Kaohsiung J Med Sci Subsets: MEDLINE
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  Data: Effects of Sofosbuvir/Velpatasvir Therapy on Extrahepatic Manifestations in Patients With Type 2 Diabetes and Chronic Hepatitis C: Insights From a Nationwide Hepatitis C Virus Registry in Taiwan.
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  Data: <searchLink fieldCode="AU" term="%22Wang+SJ%22">Wang SJ</searchLink>; Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Division of Hepatogastroenterology, Department of Internal Medicine, Shin Huey Shin Hospital, Kaohsiung, Taiwan.; Division of Gastroenterology, Department of Internal Medicine, Yuan's General Hospital, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+TS%22">Chang TS</searchLink>; Division of Hepatogastroenterology, Department of Internal Medicine, ChiaYi Chang Gung Memorial Hospital, Chiayi, Taiwan.; College of Medicine, Chang Gung University, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lo+CC%22">Lo CC</searchLink>; Division of Gastroenterology, Department of Internal Medicine, St. Martin De Porres Hospital, Chiayi, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hung+CH%22">Hung CH</searchLink>; Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+CW%22">Huang CW</searchLink>; Division of Gastroenterology, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chong+LW%22">Chong LW</searchLink>; Division of Hepatology and Gastroenterology, Department of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.; School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Cheng+PN%22">Cheng PN</searchLink>; Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Bair+MJ%22">Bair MJ</searchLink>; Division of Gastroenterology, Department of Internal Medicine, Taitung Mackay Memorial Hospital, Taitung, Taiwan.; Mackay Medical College, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yeh+ML%22">Yeh ML</searchLink>; Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Hepatitis Research Center, College of Medicine; Center for Metabolic Disorders and Obesity, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Peng+CY%22">Peng CY</searchLink>; Center for Digestive Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.; School of Medicine, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Cheng+CY%22">Cheng CY</searchLink>; Division of Infectious Diseases, Department of Internal Medicine, Taoyuan General Hsopital, Ministry of Health and Welfare, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+JF%22">Huang JF</searchLink>; Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Hepatitis Research Center, College of Medicine; Center for Metabolic Disorders and Obesity, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+CL%22">Lin CL</searchLink>; Liver Research Unit, Department of Hepato Gastroenterology and Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, College of Medicine, Chang Gung University, Keelung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yang+CC%22">Yang CC</searchLink>; Department of Gastroenterology, Division of Internal Medicine, Show Chwan Memorial Hospital, Changhua, Taiwan.<br /><searchLink fieldCode="AU" term="%22Kuo+HT%22">Kuo HT</searchLink>; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsieh+TY%22">Hsieh TY</searchLink>; Division of Gastroenterology, Department of Internal Medicine, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+TH%22">Lee TH</searchLink>; Division of Gastroenterology and Hepatology, Far Eastern Memorial Hospital, New Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+PL%22">Lee PL</searchLink>; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chi Mei Medical Center, Liouying, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+WC%22">Wu WC</searchLink>; Wen-Chih Wu Clinic, Fengshan, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+CL%22">Lin CL</searchLink>; Department of Gastroenterology, Renai Branch, Taipei City Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Su+WW%22">Su WW</searchLink>; Department of Gastroenterology and Hepatology, Changhua Christian Hospital, Changhua, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yang+SS%22">Yang SS</searchLink>; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+CC%22">Wang CC</searchLink>; Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation and School of Medicine, Tzu Chi University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hu+JT%22">Hu JT</searchLink>; Liver Center, Cathay General Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Mo+LR%22">Mo LR</searchLink>; Division of Gastroenterology, Tainan Municipal Hospital (Managed By Show Chwan Medical Care Corporation), Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+CT%22">Chen CT</searchLink>; Division of Gastroenterology, Department of Internal Medicine tri Service, General Hospital Penghu Branch, National Defense Medical Center, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+YH%22">Huang YH</searchLink>; Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan.; Institute of Clinical Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+CC%22">Chang CC</searchLink>; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan.; Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+CS%22">Huang CS</searchLink>; Yang Ming Hospital, Chiayi, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+GY%22">Chen GY</searchLink>; Penghu Hospital, Ministry of Health and Welfare, Penghu, Taiwan.<br /><searchLink fieldCode="AU" term="%22Kao+CN%22">Kao CN</searchLink>; National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tai+CM%22">Tai CM</searchLink>; Division of Gastroenterology and Hepatology, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.; School of Medicine for International Students, College of Medicine, I-Shou University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+CJ%22">Liu CJ</searchLink>; Hepatitis Research Center and Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+MH%22">Lee MH</searchLink>; Institute of Clinical Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tsai+PC%22">Tsai PC</searchLink>; Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Hepatitis Research Center, College of Medicine; Center for Metabolic Disorders and Obesity, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+SC%22">Wang SC</searchLink>; Hepatitis Research Center, College of Medicine; Center for Metabolic Disorders and Obesity, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Dai+CY%22">Dai CY</searchLink>; Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Hepatitis Research Center, College of Medicine; Center for Metabolic Disorders and Obesity, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Kao+JH%22">Kao JH</searchLink>; Hepatitis Research Center and Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+HC%22">Lin HC</searchLink>; Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan.; Institute of Clinical Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chuang+WL%22">Chuang WL</searchLink>; Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Hepatitis Research Center, College of Medicine; Center for Metabolic Disorders and Obesity, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tseng+KC%22">Tseng KC</searchLink>; School of Medicine, Tzuchi University, Hualien, Taiwan.; Department of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+CY%22">Chen CY</searchLink>; Division of Gastroenterology and Hepatology, Department of Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+CF%22">Huang CF</searchLink>; Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Hepatitis Research Center, College of Medicine; Center for Metabolic Disorders and Obesity, Kaohsiung Medical University, Kaohsiung, Taiwan.; Ph.D. Program in Translational Medicine, College of Medicine, Kaohsiung Medical University, Academia Sinica, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yu+ML%22">Yu ML</searchLink>; Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.; Hepatitis Research Center, College of Medicine; Center for Metabolic Disorders and Obesity, Kaohsiung Medical University, Kaohsiung, Taiwan.; Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University, Kaohsiung, Taiwan.
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  Data: <searchLink fieldCode="JN" term="%22100960562%22">The Kaohsiung journal of medical sciences</searchLink> [Kaohsiung J Med Sci] 2025 Nov; Vol. 41 (11), pp. e70067. <i>Date of Electronic Publication: </i>2025 Jun 20.
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            – Type: issue
              Value: 11
          Titles:
            – TitleFull: The Kaohsiung journal of medical sciences
              Type: main
ResultId 1