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Lysosomal Cathepsin S Escape Facilitates Near Infrared Light-Triggered Pyroptosis Via an Antibody-Indocyanine Green Conjugate.

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Title: Lysosomal Cathepsin S Escape Facilitates Near Infrared Light-Triggered Pyroptosis Via an Antibody-Indocyanine Green Conjugate.
Authors: Chen F; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310018, China.; Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan, 410082, China., Tian XF; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310018, China.; School of Molecular Medicine, Hangzhou Institute for Advanced Study, UCAS, Hangzhou, 310024, China., Yang T; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310018, China.; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, Zhejiang, 310014, China., Dai YJ; MabPlex International, Yantai, Shandong, 264006, China., Chen DY; Guilin University of Electronic Technology, Guilin, Guangxi, 541004, China., Chen HB; Guilin University of Electronic Technology, Guilin, Guangxi, 541004, China., Shimura T; Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, 467-8601, Japan., Li XF; MabPlex International, Yantai, Shandong, 264006, China., Sha CL; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310018, China., Ji Q; Department of Head and Neck and Rare Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, 310022, China., Cao J; Department of Head and Neck and Rare Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, 310022, China., Fang MY; Department of Head and Neck and Rare Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, 310022, China., Shang JB; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310018, China., Fang JM; School of Life Science and Technology, Tongji University, Shanghai, 200092, China., Lu Y; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310018, China., Zheng WH; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310018, China., Guo P; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310018, China.; School of Molecular Medicine, Hangzhou Institute for Advanced Study, UCAS, Hangzhou, 310024, China., Tan WH; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310018, China.; School of Molecular Medicine, Hangzhou Institute for Advanced Study, UCAS, Hangzhou, 310024, China.
Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Sep; Vol. 12 (34), pp. e04851. Date of Electronic Publication: 2025 Jun 20.
Publication Type: Journal Article
Journal Info: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Chen+F%22">Chen F</searchLink>; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310018, China.; Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan, 410082, China.<br /><searchLink fieldCode="AU" term="%22Tian+XF%22">Tian XF</searchLink>; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310018, China.; School of Molecular Medicine, Hangzhou Institute for Advanced Study, UCAS, Hangzhou, 310024, China.<br /><searchLink fieldCode="AU" term="%22Yang+T%22">Yang T</searchLink>; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310018, China.; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, Zhejiang, 310014, China.<br /><searchLink fieldCode="AU" term="%22Dai+YJ%22">Dai YJ</searchLink>; MabPlex International, Yantai, Shandong, 264006, China.<br /><searchLink fieldCode="AU" term="%22Chen+DY%22">Chen DY</searchLink>; Guilin University of Electronic Technology, Guilin, Guangxi, 541004, China.<br /><searchLink fieldCode="AU" term="%22Chen+HB%22">Chen HB</searchLink>; Guilin University of Electronic Technology, Guilin, Guangxi, 541004, China.<br /><searchLink fieldCode="AU" term="%22Shimura+T%22">Shimura T</searchLink>; Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, 467-8601, Japan.<br /><searchLink fieldCode="AU" term="%22Li+XF%22">Li XF</searchLink>; MabPlex International, Yantai, Shandong, 264006, China.<br /><searchLink fieldCode="AU" term="%22Sha+CL%22">Sha CL</searchLink>; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310018, China.<br /><searchLink fieldCode="AU" term="%22Ji+Q%22">Ji Q</searchLink>; Department of Head and Neck and Rare Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, 310022, China.<br /><searchLink fieldCode="AU" term="%22Cao+J%22">Cao J</searchLink>; Department of Head and Neck and Rare Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, 310022, China.<br /><searchLink fieldCode="AU" term="%22Fang+MY%22">Fang MY</searchLink>; Department of Head and Neck and Rare Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, 310022, China.<br /><searchLink fieldCode="AU" term="%22Shang+JB%22">Shang JB</searchLink>; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310018, China.<br /><searchLink fieldCode="AU" term="%22Fang+JM%22">Fang JM</searchLink>; School of Life Science and Technology, Tongji University, Shanghai, 200092, China.<br /><searchLink fieldCode="AU" term="%22Lu+Y%22">Lu Y</searchLink>; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310018, China.<br /><searchLink fieldCode="AU" term="%22Zheng+WH%22">Zheng WH</searchLink>; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310018, China.<br /><searchLink fieldCode="AU" term="%22Guo+P%22">Guo P</searchLink>; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310018, China.; School of Molecular Medicine, Hangzhou Institute for Advanced Study, UCAS, Hangzhou, 310024, China.<br /><searchLink fieldCode="AU" term="%22Tan+WH%22">Tan WH</searchLink>; Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310018, China.; School of Molecular Medicine, Hangzhou Institute for Advanced Study, UCAS, Hangzhou, 310024, China.
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