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Tirzepatide for reduction of morbidity and mortality in adults with obesity: rationale and design of the SURMOUNT-MMO trial.

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Title: Tirzepatide for reduction of morbidity and mortality in adults with obesity: rationale and design of the SURMOUNT-MMO trial.
Authors: Lam CSP; Cardiovascular and Metabolic Disorders Programme, Duke-National University of Singapore Medical School, Singapore, Singapore.; National Heart Centre Singapore, Singapore, Singapore., Rodriguez A; Eli Lilly and Company, Indianapolis, Indiana, USA., Aminian A; Bariatric and Metabolic Institute, Department of General Surgery, Cleveland Clinic, Cleveland, Ohio, USA., Ferrannini E; Endocrinology and Metabolic Diseases, CNR Institute of Clinical Physiology, Pisa, Italy., Heerspink HJL; Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.; The George Institute for Global Health, Sydney, New South Wales, Australia., Jastreboff AM; Department of Medicine (Endocrinology and Metabolism) and Pediatrics (Pediatric Endocrinology), Yale University School of Medicine, New Haven, Connecticut, USA., Laffin LJ; Section of Preventive Cardiology and Rehabilitation, Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA., Pandey A; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Ray KK; Department of Primary Care and Public Health, Imperial College London, London, UK., Ridker PM; Divisions of Cardiovascular Medicine and Preventive Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Sanyal AJ; Stravitz-Sanyal Institute for Liver Disease and Metabolic Health and Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA., Yki-Jarvinen H; Department of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Minerva Foundation Institute for Medical Research, Helsinki, Finland., Mason D; Cleveland Clinic Coordinating Center for Clinical Research, Cleveland, Ohio, USA., Strzelecki M; Cleveland Clinic Coordinating Center for Clinical Research, Cleveland, Ohio, USA., Bartee AK; Eli Lilly and Company, Indianapolis, Indiana, USA., Cui C; Eli Lilly and Company, Indianapolis, Indiana, USA., Hurt K; Eli Lilly and Company, Indianapolis, Indiana, USA., Linetzky B; Eli Lilly and Company, Indianapolis, Indiana, USA., Bunck MC; Eli Lilly and Company, Indianapolis, Indiana, USA., Nissen SE; Cleveland Clinic Coordinating Center for Clinical Research, Cardiology/Clinical Trials, Cleveland, Ohio, USA.
Source: Obesity (Silver Spring, Md.) [Obesity (Silver Spring)] 2025 Sep; Vol. 33 (9), pp. 1645-1656. Date of Electronic Publication: 2025 Jun 22.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101264860 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1930-739X (Electronic) Linking ISSN: 19307381 NLM ISO Abbreviation: Obesity (Silver Spring) Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Lam+CSP%22">Lam CSP</searchLink>; Cardiovascular and Metabolic Disorders Programme, Duke-National University of Singapore Medical School, Singapore, Singapore.; National Heart Centre Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Rodriguez+A%22">Rodriguez A</searchLink>; Eli Lilly and Company, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Aminian+A%22">Aminian A</searchLink>; Bariatric and Metabolic Institute, Department of General Surgery, Cleveland Clinic, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Ferrannini+E%22">Ferrannini E</searchLink>; Endocrinology and Metabolic Diseases, CNR Institute of Clinical Physiology, Pisa, Italy.<br /><searchLink fieldCode="AU" term="%22Heerspink+HJL%22">Heerspink HJL</searchLink>; Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.; The George Institute for Global Health, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Jastreboff+AM%22">Jastreboff AM</searchLink>; Department of Medicine (Endocrinology and Metabolism) and Pediatrics (Pediatric Endocrinology), Yale University School of Medicine, New Haven, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Laffin+LJ%22">Laffin LJ</searchLink>; Section of Preventive Cardiology and Rehabilitation, Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Pandey+A%22">Pandey A</searchLink>; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Ray+KK%22">Ray KK</searchLink>; Department of Primary Care and Public Health, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Ridker+PM%22">Ridker PM</searchLink>; Divisions of Cardiovascular Medicine and Preventive Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Sanyal+AJ%22">Sanyal AJ</searchLink>; Stravitz-Sanyal Institute for Liver Disease and Metabolic Health and Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.<br /><searchLink fieldCode="AU" term="%22Yki-Jarvinen+H%22">Yki-Jarvinen H</searchLink>; Department of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Minerva Foundation Institute for Medical Research, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Mason+D%22">Mason D</searchLink>; Cleveland Clinic Coordinating Center for Clinical Research, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Strzelecki+M%22">Strzelecki M</searchLink>; Cleveland Clinic Coordinating Center for Clinical Research, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Bartee+AK%22">Bartee AK</searchLink>; Eli Lilly and Company, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Cui+C%22">Cui C</searchLink>; Eli Lilly and Company, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Hurt+K%22">Hurt K</searchLink>; Eli Lilly and Company, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Linetzky+B%22">Linetzky B</searchLink>; Eli Lilly and Company, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Bunck+MC%22">Bunck MC</searchLink>; Eli Lilly and Company, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Nissen+SE%22">Nissen SE</searchLink>; Cleveland Clinic Coordinating Center for Clinical Research, Cardiology/Clinical Trials, Cleveland, Ohio, USA.
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  Data: <searchLink fieldCode="JN" term="%22101264860%22">Obesity (Silver Spring, Md.)</searchLink> [Obesity (Silver Spring)] 2025 Sep; Vol. 33 (9), pp. 1645-1656. <i>Date of Electronic Publication: </i>2025 Jun 22.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22John+Wiley+%26+Sons%22">John Wiley & Sons </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101264860 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1930-739X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219307381%22">19307381 </searchLink><i>NLM ISO Abbreviation: </i>Obesity (Silver Spring) <i>Subsets: </i>MEDLINE
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