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Assessing the System-Instruction Vulnerabilities of Large Language Models to Malicious Conversion Into Health Disinformation Chatbots.

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Title: Assessing the System-Instruction Vulnerabilities of Large Language Models to Malicious Conversion Into Health Disinformation Chatbots.
Authors: Modi ND; Flinders University, College of Medicine and Public Health, Flinders Health and Medical Research Institute, and Clinical and Health Sciences, University of South Australia, Adelaide, Australia (N.D.M.)., Menz BD; Flinders University, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Adelaide, Australia (B.D.M., A.A.A., C.A.A., R.A.M., A.R., M.J.S., A.M.H.)., Awaty AA; Flinders University, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Adelaide, Australia (B.D.M., A.A.A., C.A.A., R.A.M., A.R., M.J.S., A.M.H.)., Alex CA; Flinders University, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Adelaide, Australia (B.D.M., A.A.A., C.A.A., R.A.M., A.R., M.J.S., A.M.H.)., Logan JM; Clinical and Health Sciences, University of South Australia, Adelaide, Australia (J.M.L.)., McKinnon RA; Flinders University, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Adelaide, Australia (B.D.M., A.A.A., C.A.A., R.A.M., A.R., M.J.S., A.M.H.)., Rowland A; Flinders University, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Adelaide, Australia (B.D.M., A.A.A., C.A.A., R.A.M., A.R., M.J.S., A.M.H.)., Bacchi S; Department of Neurology and the Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts (S.B.)., Gradon K; Department of Security and Crime Science, University College London, London, United Kingdom, and Department of Cybersecurity, Warsaw University of Technology, Warsaw, Poland (K.G.)., Sorich MJ; Flinders University, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Adelaide, Australia (B.D.M., A.A.A., C.A.A., R.A.M., A.R., M.J.S., A.M.H.)., Hopkins AM; Flinders University, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Adelaide, Australia (B.D.M., A.A.A., C.A.A., R.A.M., A.R., M.J.S., A.M.H.).
Source: Annals of internal medicine [Ann Intern Med] 2025 Aug; Vol. 178 (8), pp. 1172-1180. Date of Electronic Publication: 2025 Jun 24.
Publication Type: Journal Article; Review
Journal Info: Publisher: American College of Physicians--American Society of Internal Medicine Country of Publication: United States NLM ID: 0372351 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1539-3704 (Electronic) Linking ISSN: 00034819 NLM ISO Abbreviation: Ann Intern Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Assessing the System-Instruction Vulnerabilities of Large Language Models to Malicious Conversion Into Health Disinformation Chatbots.
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  Data: <searchLink fieldCode="AU" term="%22Modi+ND%22">Modi ND</searchLink>; Flinders University, College of Medicine and Public Health, Flinders Health and Medical Research Institute, and Clinical and Health Sciences, University of South Australia, Adelaide, Australia (N.D.M.).<br /><searchLink fieldCode="AU" term="%22Menz+BD%22">Menz BD</searchLink>; Flinders University, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Adelaide, Australia (B.D.M., A.A.A., C.A.A., R.A.M., A.R., M.J.S., A.M.H.).<br /><searchLink fieldCode="AU" term="%22Awaty+AA%22">Awaty AA</searchLink>; Flinders University, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Adelaide, Australia (B.D.M., A.A.A., C.A.A., R.A.M., A.R., M.J.S., A.M.H.).<br /><searchLink fieldCode="AU" term="%22Alex+CA%22">Alex CA</searchLink>; Flinders University, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Adelaide, Australia (B.D.M., A.A.A., C.A.A., R.A.M., A.R., M.J.S., A.M.H.).<br /><searchLink fieldCode="AU" term="%22Logan+JM%22">Logan JM</searchLink>; Clinical and Health Sciences, University of South Australia, Adelaide, Australia (J.M.L.).<br /><searchLink fieldCode="AU" term="%22McKinnon+RA%22">McKinnon RA</searchLink>; Flinders University, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Adelaide, Australia (B.D.M., A.A.A., C.A.A., R.A.M., A.R., M.J.S., A.M.H.).<br /><searchLink fieldCode="AU" term="%22Rowland+A%22">Rowland A</searchLink>; Flinders University, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Adelaide, Australia (B.D.M., A.A.A., C.A.A., R.A.M., A.R., M.J.S., A.M.H.).<br /><searchLink fieldCode="AU" term="%22Bacchi+S%22">Bacchi S</searchLink>; Department of Neurology and the Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts (S.B.).<br /><searchLink fieldCode="AU" term="%22Gradon+K%22">Gradon K</searchLink>; Department of Security and Crime Science, University College London, London, United Kingdom, and Department of Cybersecurity, Warsaw University of Technology, Warsaw, Poland (K.G.).<br /><searchLink fieldCode="AU" term="%22Sorich+MJ%22">Sorich MJ</searchLink>; Flinders University, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Adelaide, Australia (B.D.M., A.A.A., C.A.A., R.A.M., A.R., M.J.S., A.M.H.).<br /><searchLink fieldCode="AU" term="%22Hopkins+AM%22">Hopkins AM</searchLink>; Flinders University, College of Medicine and Public Health, Flinders Health and Medical Research Institute, Adelaide, Australia (B.D.M., A.A.A., C.A.A., R.A.M., A.R., M.J.S., A.M.H.).
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  Data: <searchLink fieldCode="JN" term="%220372351%22">Annals of internal medicine</searchLink> [Ann Intern Med] 2025 Aug; Vol. 178 (8), pp. 1172-1180. <i>Date of Electronic Publication: </i>2025 Jun 24.
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