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Multiple TET2 mutations confer additional survival benefit in both myelodysplastic and myeloproliferative chronic myelomonocytic leukemia subtypes.

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Title: Multiple TET2 mutations confer additional survival benefit in both myelodysplastic and myeloproliferative chronic myelomonocytic leukemia subtypes.
Authors: Csizmar CM; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, 55905, USA., Natu A; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, 55905, USA., Gurney M; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, 55905, USA., Fathima S; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, 55905, USA., Alsugair AKA; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, 55905, USA., Kanagal-Shamanna R; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Loghavi S; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Bazinet A; Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Chien K; Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Hammond D; Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., DiNardo C; Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Kadia T; Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Ravandi-Kashani F; Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Pemmaraju N; Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Sasaki K; Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Lasho TL; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, 55905, USA., Finke CM; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, 55905, USA., Al-Kali A; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, 55905, USA., Alkhateeb H; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, 55905, USA., Begna K; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, 55905, USA., Gangat N; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, 55905, USA., Hefazi Torghabeh M; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, 55905, USA., Matin A; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, 55905, USA., Mangaonkar AA; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, 55905, USA., Saliba AN; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, 55905, USA., Tefferi A; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, 55905, USA., Garcia-Manero G; Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Kantarjian HM; Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Komrokji RS; Department of Malignant Hematology, H. Lee Moffitt Cancer Center, Tampa, FL, 33612, USA., Xie Z; Department of Malignant Hematology, H. Lee Moffitt Cancer Center, Tampa, FL, 33612, USA., Ali NA; Department of Malignant Hematology, H. Lee Moffitt Cancer Center, Tampa, FL, 33612, USA., Sallman D; Department of Malignant Hematology, H. Lee Moffitt Cancer Center, Tampa, FL, 33612, USA., Padron E; Department of Malignant Hematology, H. Lee Moffitt Cancer Center, Tampa, FL, 33612, USA., Montalban-Bravo G; Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Patnaik MM; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, 55905, USA. patnaik.mrinal@mayo.edu.
Source: Leukemia [Leukemia] 2025 Aug; Vol. 39 (8), pp. 2030-2034. Date of Electronic Publication: 2025 Jun 24.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE; In Process
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  Data: Multiple TET2 mutations confer additional survival benefit in both myelodysplastic and myeloproliferative chronic myelomonocytic leukemia subtypes.
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Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Ravandi-Kashani+F%22">Ravandi-Kashani F</searchLink>; Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Pemmaraju+N%22">Pemmaraju N</searchLink>; Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Sasaki+K%22">Sasaki K</searchLink>; Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Lasho+TL%22">Lasho TL</searchLink>; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Finke+CM%22">Finke CM</searchLink>; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Al-Kali+A%22">Al-Kali A</searchLink>; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Alkhateeb+H%22">Alkhateeb H</searchLink>; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Begna+K%22">Begna K</searchLink>; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Gangat+N%22">Gangat N</searchLink>; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Hefazi+Torghabeh+M%22">Hefazi Torghabeh M</searchLink>; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Matin+A%22">Matin A</searchLink>; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Mangaonkar+AA%22">Mangaonkar AA</searchLink>; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Saliba+AN%22">Saliba AN</searchLink>; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Tefferi+A%22">Tefferi A</searchLink>; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Garcia-Manero+G%22">Garcia-Manero G</searchLink>; Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Kantarjian+HM%22">Kantarjian HM</searchLink>; Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Komrokji+RS%22">Komrokji RS</searchLink>; Department of Malignant Hematology, H. Lee Moffitt Cancer Center, Tampa, FL, 33612, USA.<br /><searchLink fieldCode="AU" term="%22Xie+Z%22">Xie Z</searchLink>; Department of Malignant Hematology, H. Lee Moffitt Cancer Center, Tampa, FL, 33612, USA.<br /><searchLink fieldCode="AU" term="%22Ali+NA%22">Ali NA</searchLink>; Department of Malignant Hematology, H. Lee Moffitt Cancer Center, Tampa, FL, 33612, USA.<br /><searchLink fieldCode="AU" term="%22Sallman+D%22">Sallman D</searchLink>; Department of Malignant Hematology, H. Lee Moffitt Cancer Center, Tampa, FL, 33612, USA.<br /><searchLink fieldCode="AU" term="%22Padron+E%22">Padron E</searchLink>; Department of Malignant Hematology, H. Lee Moffitt Cancer Center, Tampa, FL, 33612, USA.<br /><searchLink fieldCode="AU" term="%22Montalban-Bravo+G%22">Montalban-Bravo G</searchLink>; Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Patnaik+MM%22">Patnaik MM</searchLink>; Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, 55905, USA. patnaik.mrinal@mayo.edu.
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