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Integrative Molecular and Immune Profiling in Advanced Unresectable Melanoma: Tumor Microenvironment and Peripheral PD-1+ CD4+ Effector Memory T-Cells as Potential Markers of Response to Immune Checkpoint Inhibitor Therapy.

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Title: Integrative Molecular and Immune Profiling in Advanced Unresectable Melanoma: Tumor Microenvironment and Peripheral PD-1+ CD4+ Effector Memory T-Cells as Potential Markers of Response to Immune Checkpoint Inhibitor Therapy.
Authors: Molina-García M; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), c. Casanova 143, 08036 Barcelona, Spain.; Melanoma Unit, Dermatology Department, Hospital Clinic of Barcelona, 170 Villarroel, 08036 Barcelona, Spain., Rojas-Lechuga MJ; Otorhinolaryngology Department, Hospital Clínic de Barcelona, CIBERES, IDIBAPS, Universitat de Barcelona, 08036 Barcelona, Spain., Torres Moral T; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Melanoma Unit, Dermatology Department, Hospital Clinic of Barcelona, 170 Villarroel, 08036 Barcelona, Spain.; Centre of Biomedical Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, 08036 Barcelona, Spain., Crespí-Payeras F; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), c. Casanova 143, 08036 Barcelona, Spain.; Melanoma Unit, Dermatology Department, Hospital Clinic of Barcelona, 170 Villarroel, 08036 Barcelona, Spain.; Centre of Biomedical Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, 08036 Barcelona, Spain., Bagué J; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), c. Casanova 143, 08036 Barcelona, Spain.; Melanoma Unit, Dermatology Department, Hospital Clinic of Barcelona, 170 Villarroel, 08036 Barcelona, Spain., Mateu J; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Melanoma Unit, Dermatology Department, Hospital Clinic of Barcelona, 170 Villarroel, 08036 Barcelona, Spain., Paschalidis N; Biomedical Research Foundation, Academy of Athens (BRFAA), 4 Soranou Efesiou St., 11527 Athens, Greece., de Souza VG; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, SP, Brazil., Podlipnik S; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), c. Casanova 143, 08036 Barcelona, Spain.; Melanoma Unit, Dermatology Department, Hospital Clinic of Barcelona, 170 Villarroel, 08036 Barcelona, Spain., Carrera C; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), c. Casanova 143, 08036 Barcelona, Spain.; Melanoma Unit, Dermatology Department, Hospital Clinic of Barcelona, 170 Villarroel, 08036 Barcelona, Spain.; Centre of Biomedical Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, 08036 Barcelona, Spain., Malvehy J; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), c. Casanova 143, 08036 Barcelona, Spain.; Melanoma Unit, Dermatology Department, Hospital Clinic of Barcelona, 170 Villarroel, 08036 Barcelona, Spain.; Centre of Biomedical Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, 08036 Barcelona, Spain., da Silva-Júnior RMP; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Melanoma Unit, Dermatology Department, Hospital Clinic of Barcelona, 170 Villarroel, 08036 Barcelona, Spain.; Department of Cell and Molecular Biology, Faculty of Medicine of Ribeirão Preto, University of São Paulo (FMRP-USP), Ribeirão Preto 14049-900, SP, Brazil., Puig S; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), c. Casanova 143, 08036 Barcelona, Spain.; Melanoma Unit, Dermatology Department, Hospital Clinic of Barcelona, 170 Villarroel, 08036 Barcelona, Spain.; Centre of Biomedical Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, 08036 Barcelona, Spain.
Source: Cancers [Cancers (Basel)] 2025 Jun 17; Vol. 17 (12). Date of Electronic Publication: 2025 Jun 17.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101526829 Publication Model: Electronic Cited Medium: Print ISSN: 2072-6694 (Print) Linking ISSN: 20726694 NLM ISO Abbreviation: Cancers (Basel) Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Integrative Molecular and Immune Profiling in Advanced Unresectable Melanoma: Tumor Microenvironment and Peripheral PD-1+ CD4+ Effector Memory T-Cells as Potential Markers of Response to Immune Checkpoint Inhibitor Therapy.
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  Data: <searchLink fieldCode="AU" term="%22Molina-García+M%22">Molina-García M</searchLink>; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), c. Casanova 143, 08036 Barcelona, Spain.; Melanoma Unit, Dermatology Department, Hospital Clinic of Barcelona, 170 Villarroel, 08036 Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Rojas-Lechuga+MJ%22">Rojas-Lechuga MJ</searchLink>; Otorhinolaryngology Department, Hospital Clínic de Barcelona, CIBERES, IDIBAPS, Universitat de Barcelona, 08036 Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Torres+Moral+T%22">Torres Moral T</searchLink>; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Melanoma Unit, Dermatology Department, Hospital Clinic of Barcelona, 170 Villarroel, 08036 Barcelona, Spain.; Centre of Biomedical Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, 08036 Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Crespí-Payeras+F%22">Crespí-Payeras F</searchLink>; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), c. Casanova 143, 08036 Barcelona, Spain.; Melanoma Unit, Dermatology Department, Hospital Clinic of Barcelona, 170 Villarroel, 08036 Barcelona, Spain.; Centre of Biomedical Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, 08036 Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Bagué+J%22">Bagué J</searchLink>; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), c. Casanova 143, 08036 Barcelona, Spain.; Melanoma Unit, Dermatology Department, Hospital Clinic of Barcelona, 170 Villarroel, 08036 Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Mateu+J%22">Mateu J</searchLink>; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Melanoma Unit, Dermatology Department, Hospital Clinic of Barcelona, 170 Villarroel, 08036 Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Paschalidis+N%22">Paschalidis N</searchLink>; Biomedical Research Foundation, Academy of Athens (BRFAA), 4 Soranou Efesiou St., 11527 Athens, Greece.<br /><searchLink fieldCode="AU" term="%22de+Souza+VG%22">de Souza VG</searchLink>; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Podlipnik+S%22">Podlipnik S</searchLink>; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), c. Casanova 143, 08036 Barcelona, Spain.; Melanoma Unit, Dermatology Department, Hospital Clinic of Barcelona, 170 Villarroel, 08036 Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Carrera+C%22">Carrera C</searchLink>; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), c. Casanova 143, 08036 Barcelona, Spain.; Melanoma Unit, Dermatology Department, Hospital Clinic of Barcelona, 170 Villarroel, 08036 Barcelona, Spain.; Centre of Biomedical Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, 08036 Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Malvehy+J%22">Malvehy J</searchLink>; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), c. Casanova 143, 08036 Barcelona, Spain.; Melanoma Unit, Dermatology Department, Hospital Clinic of Barcelona, 170 Villarroel, 08036 Barcelona, Spain.; Centre of Biomedical Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, 08036 Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22da+Silva-Júnior+RMP%22">da Silva-Júnior RMP</searchLink>; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Melanoma Unit, Dermatology Department, Hospital Clinic of Barcelona, 170 Villarroel, 08036 Barcelona, Spain.; Department of Cell and Molecular Biology, Faculty of Medicine of Ribeirão Preto, University of São Paulo (FMRP-USP), Ribeirão Preto 14049-900, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Puig+S%22">Puig S</searchLink>; Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), c. Casanova 143, 08036 Barcelona, Spain.; Melanoma Unit, Dermatology Department, Hospital Clinic of Barcelona, 170 Villarroel, 08036 Barcelona, Spain.; Centre of Biomedical Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, 08036 Barcelona, Spain.
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  Data: <searchLink fieldCode="JN" term="%22101526829%22">Cancers</searchLink> [Cancers (Basel)] 2025 Jun 17; Vol. 17 (12). <i>Date of Electronic Publication: </i>2025 Jun 17.
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