Whole genome sequence association analysis of brain structural volume measures in the NHLBI TOPMed Program highlights novel loci in diverse participants.

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Bibliographic Details
Title: Whole genome sequence association analysis of brain structural volume measures in the NHLBI TOPMed Program highlights novel loci in diverse participants.
Authors: Shade LM; Department of Biostatistics, University of Kentucky, Lexington, KY., Sharifitabar M; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, The University of Texas Health Science Center at San Antonio, San Antonio, TX.; Department of Cell Systems and Anatomy, University of Texas Health Sciences Center, San Antonio, TX., Beiser A; Department of Biostatistics, Boston University, School of Public Health, Boston, MA.; Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Botson, MA.; The Framingham Heart Study, Framingham, MA., Satizabal CL; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, The University of Texas Health Science Center at San Antonio, San Antonio, TX.; Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Botson, MA.; The Framingham Heart Study, Framingham, MA., Mosley TH; Department of Medicine, University of Mississippi Medical Center, Jackson, MS., Curran JE; Division of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX., Bressler J; Human Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX., Heckbert SR; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA.; Department of Epidemiology, University of Washington, Seattle, WA., Hughes TM; Departments of Internal Medicine and Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC., Austin TR; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA.; Department of Epidemiology, University of Washington, Seattle, WA., Nasrallah IM; Center for Biomedical Image Computing and Analytics, Department of Radiology, University of Pennsylvania, Philadelphia., Launer LJ; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD., Yanek LR; GeneSTAR Research Program, Johns Hopkins University School of Medicine, Baltimore, MD., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA., Doddapaneni H; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX., Gibbs RA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX., Gabriel S; Genomics Platform, Broad Institute, Cambridge, MA., Gupta N; Genomics Platform, Broad Institute, Cambridge, MA., Viaud-Martinez KA; Illumina Laboratory Services, Illumina.Inc, 5200 Illumina Way, San Diego, CA., Smith AV; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI., Opsasnick LA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI., Ammous F; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI., Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI., Arnett DK; Office of the Provost, University of South Carolina, Columbia, SC., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA.; Department of Epidemiology, University of Washington, Seattle, WA.; Departments of Medicine and Population Health and Health Systems, University of Washington, Seattle, WA., Longstreth WT Jr; Department of Epidemiology, University of Washington, Seattle, WA.; Department of Neurology, University of Washington, Seattle, WA., Mathias RA; GeneSTAR Research Program, Johns Hopkins University School of Medicine, Baltimore, MD.; Genomics and Precision Health Section, Laboratory of Allergic Diseases, National Institutes of Allergy and Infection Diseases, Bethesda, MD., Nyquist P; Johns Hopkins School of Medicine, Department of Neurology, Baltimore, MD., Rich SS; Department of Genome Sciences, University of Virginia School of Medicine, Charlottesville, VA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA., Boerwinkle E; Human Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX., DeCarli CS; Department of Neurology, University of California, Davis, CA., Glahn DC; Department of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Boston, MA.; Department of Psychiatry, Harvard Medical School, Boston, MA.; Olin Neuropsychiatry Research Center, Institute of Living, Hartford, CT., Blangero J; Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Botson, MA., Fornage M; Human Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX.; The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, McGovern Medical School, Houston, TX., Fardo DW; Department of Biostatistics, University of Kentucky, Lexington, KY., Seshadri S; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, The University of Texas Health Science Center at San Antonio, San Antonio, TX.; Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Botson, MA.; The Framingham Heart Study, Framingham, MA., Sarnowski C; Human Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2025 Jun 13. Date of Electronic Publication: 2025 Jun 13.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
DOI:10.1101/2025.06.11.25329426