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Whole genome sequence association analysis of brain structural volume measures in the NHLBI TOPMed Program highlights novel loci in diverse participants.

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Title: Whole genome sequence association analysis of brain structural volume measures in the NHLBI TOPMed Program highlights novel loci in diverse participants.
Authors: Shade LM; Department of Biostatistics, University of Kentucky, Lexington, KY., Sharifitabar M; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, The University of Texas Health Science Center at San Antonio, San Antonio, TX.; Department of Cell Systems and Anatomy, University of Texas Health Sciences Center, San Antonio, TX., Beiser A; Department of Biostatistics, Boston University, School of Public Health, Boston, MA.; Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Botson, MA.; The Framingham Heart Study, Framingham, MA., Satizabal CL; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, The University of Texas Health Science Center at San Antonio, San Antonio, TX.; Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Botson, MA.; The Framingham Heart Study, Framingham, MA., Mosley TH; Department of Medicine, University of Mississippi Medical Center, Jackson, MS., Curran JE; Division of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX., Bressler J; Human Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX., Heckbert SR; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA.; Department of Epidemiology, University of Washington, Seattle, WA., Hughes TM; Departments of Internal Medicine and Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC., Austin TR; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA.; Department of Epidemiology, University of Washington, Seattle, WA., Nasrallah IM; Center for Biomedical Image Computing and Analytics, Department of Radiology, University of Pennsylvania, Philadelphia., Launer LJ; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD., Yanek LR; GeneSTAR Research Program, Johns Hopkins University School of Medicine, Baltimore, MD., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA., Doddapaneni H; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX., Gibbs RA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX., Gabriel S; Genomics Platform, Broad Institute, Cambridge, MA., Gupta N; Genomics Platform, Broad Institute, Cambridge, MA., Viaud-Martinez KA; Illumina Laboratory Services, Illumina.Inc, 5200 Illumina Way, San Diego, CA., Smith AV; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI., Opsasnick LA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI., Ammous F; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI., Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI., Arnett DK; Office of the Provost, University of South Carolina, Columbia, SC., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA.; Department of Epidemiology, University of Washington, Seattle, WA.; Departments of Medicine and Population Health and Health Systems, University of Washington, Seattle, WA., Longstreth WT Jr; Department of Epidemiology, University of Washington, Seattle, WA.; Department of Neurology, University of Washington, Seattle, WA., Mathias RA; GeneSTAR Research Program, Johns Hopkins University School of Medicine, Baltimore, MD.; Genomics and Precision Health Section, Laboratory of Allergic Diseases, National Institutes of Allergy and Infection Diseases, Bethesda, MD., Nyquist P; Johns Hopkins School of Medicine, Department of Neurology, Baltimore, MD., Rich SS; Department of Genome Sciences, University of Virginia School of Medicine, Charlottesville, VA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA., Boerwinkle E; Human Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX., DeCarli CS; Department of Neurology, University of California, Davis, CA., Glahn DC; Department of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Boston, MA.; Department of Psychiatry, Harvard Medical School, Boston, MA.; Olin Neuropsychiatry Research Center, Institute of Living, Hartford, CT., Blangero J; Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Botson, MA., Fornage M; Human Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX.; The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, McGovern Medical School, Houston, TX., Fardo DW; Department of Biostatistics, University of Kentucky, Lexington, KY., Seshadri S; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, The University of Texas Health Science Center at San Antonio, San Antonio, TX.; Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Botson, MA.; The Framingham Heart Study, Framingham, MA., Sarnowski C; Human Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2025 Jun 13. Date of Electronic Publication: 2025 Jun 13.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Whole genome sequence association analysis of brain structural volume measures in the NHLBI TOPMed Program highlights novel loci in diverse participants.
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  Data: <searchLink fieldCode="AU" term="%22Shade+LM%22">Shade LM</searchLink>; Department of Biostatistics, University of Kentucky, Lexington, KY.<br /><searchLink fieldCode="AU" term="%22Sharifitabar+M%22">Sharifitabar M</searchLink>; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, The University of Texas Health Science Center at San Antonio, San Antonio, TX.; Department of Cell Systems and Anatomy, University of Texas Health Sciences Center, San Antonio, TX.<br /><searchLink fieldCode="AU" term="%22Beiser+A%22">Beiser A</searchLink>; Department of Biostatistics, Boston University, School of Public Health, Boston, MA.; Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Botson, MA.; The Framingham Heart Study, Framingham, MA.<br /><searchLink fieldCode="AU" term="%22Satizabal+CL%22">Satizabal CL</searchLink>; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, The University of Texas Health Science Center at San Antonio, San Antonio, TX.; 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Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI.<br /><searchLink fieldCode="AU" term="%22Ammous+F%22">Ammous F</searchLink>; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI.<br /><searchLink fieldCode="AU" term="%22Smith+JA%22">Smith JA</searchLink>; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI.<br /><searchLink fieldCode="AU" term="%22Arnett+DK%22">Arnett DK</searchLink>; Office of the Provost, University of South Carolina, Columbia, SC.<br /><searchLink fieldCode="AU" term="%22Kardia+SLR%22">Kardia SLR</searchLink>; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI.<br /><searchLink fieldCode="AU" term="%22Psaty+BM%22">Psaty BM</searchLink>; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA.; Department of Epidemiology, University of Washington, Seattle, WA.; Departments of Medicine and Population Health and Health Systems, University of Washington, Seattle, WA.<br /><searchLink fieldCode="AU" term="%22Longstreth+WT+Jr%22">Longstreth WT Jr</searchLink>; Department of Epidemiology, University of Washington, Seattle, WA.; Department of Neurology, University of Washington, Seattle, WA.<br /><searchLink fieldCode="AU" term="%22Mathias+RA%22">Mathias RA</searchLink>; GeneSTAR Research Program, Johns Hopkins University School of Medicine, Baltimore, MD.; Genomics and Precision Health Section, Laboratory of Allergic Diseases, National Institutes of Allergy and Infection Diseases, Bethesda, MD.<br /><searchLink fieldCode="AU" term="%22Nyquist+P%22">Nyquist P</searchLink>; Johns Hopkins School of Medicine, Department of Neurology, Baltimore, MD.<br /><searchLink fieldCode="AU" term="%22Rich+SS%22">Rich SS</searchLink>; Department of Genome Sciences, University of Virginia School of Medicine, Charlottesville, VA.<br /><searchLink fieldCode="AU" term="%22Rotter+JI%22">Rotter JI</searchLink>; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA.<br /><searchLink fieldCode="AU" term="%22Boerwinkle+E%22">Boerwinkle E</searchLink>; Human Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX.<br /><searchLink fieldCode="AU" term="%22DeCarli+CS%22">DeCarli CS</searchLink>; Department of Neurology, University of California, Davis, CA.<br /><searchLink fieldCode="AU" term="%22Glahn+DC%22">Glahn DC</searchLink>; Department of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Boston, MA.; Department of Psychiatry, Harvard Medical School, Boston, MA.; Olin Neuropsychiatry Research Center, Institute of Living, Hartford, CT.<br /><searchLink fieldCode="AU" term="%22Blangero+J%22">Blangero J</searchLink>; Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Botson, MA.<br /><searchLink fieldCode="AU" term="%22Fornage+M%22">Fornage M</searchLink>; Human Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX.; The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, McGovern Medical School, Houston, TX.<br /><searchLink fieldCode="AU" term="%22Fardo+DW%22">Fardo DW</searchLink>; Department of Biostatistics, University of Kentucky, Lexington, KY.<br /><searchLink fieldCode="AU" term="%22Seshadri+S%22">Seshadri S</searchLink>; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, The University of Texas Health Science Center at San Antonio, San Antonio, TX.; Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Botson, MA.; The Framingham Heart Study, Framingham, MA.<br /><searchLink fieldCode="AU" term="%22Sarnowski+C%22">Sarnowski C</searchLink>; Human Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX.
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